UNDERGRADUATE BSc. PROJECTS 2018/2019 Academic Year

1. Antimicrobial, Antioxidant and Anthelmintic Activities of Alchornea cordifolia Michael Okine and Desmond Akwata.
2. Investigating some Pharmacological Activities of Ocimum basilicum Abdulai Alhassan Naazo and Derrick Adomah Hinneh.
3. Anthelmintic, Anti-inflammatory and Antioxidant Activities of Sclerocarya birrea Benjamin Kwadzo Kokloku and Gideon Kwarteng.
4. Phytochemical Screening and Determination of Antioxidant and Antimicrobial Activities of the Crude Extracts of the Stem-Bark of Psydrax peruviana. Samuel Takyi and Rukaya Garba.
5. In Vitro Analysis and Derivatization of Local Combination Analgesic: Paracetamol, Aspirin and Caffeine on the Ghanaian Market. Joshua Dwamena Ehun.
6. In Vitro Analysis of Quinine Sulfate (300 mg). Henry Koranteng Asante.
7. Antimicrobial, Antioxidant and Anti-inflammatory Activities of the Polar and Non-polar Extracts of the Leaves of Cercestis afzelii Joshua Kofi Boafo and Richard Armah Ofosu.
8. Determination of the Antimicrobial and Antioxidant Activities of the Leaf Extracts of Griffonia simplicifolia. Prosper Dodzi Tagbor and Kingsley Bortey.
9. Phytochemical Constituents, Antimicrobial and Antioxidant Activities of the Leaves of Psydrax peruviana. Mark Amoah Kyei and Daniel Dwira Boakye.
10. In Vitro Analysis of Metronidazole Tablets on the Ghanaian Market. Noble Agyei Awuah.
11. An Assessment of the Antimicrobial, Antioxidant and Anti-inflammatory Activities of Crude Extracts of the Stem-Bark of Ficus sur. Osei Kwame and Aning Bartholomew Boateng.
12. In Vitro Drug Analysis of Local and Foreign Aspirin Tablets on the Ghanaian Market. Jefferson Addai-Poku Tuffour.
13. In Vitro Analysis of Furosemide (40 mg) Tablets Sold on the Ghanaian Market. Adelaide Owusua Afful.
14. In Vitro Analysis of Diazepam (10 mg) on the Ghanaian Market. Angela Frimpong-Wiafe.
15. In Vitro Drug Analysis of Penicillin V Potassium Tablets. Richard Sarfo Osei.
16. In Vitro Analysis of Local and Foreign Cetirizine Hydrochloride Tablets Sold on the Ghanaian Market. Priscilla Brago Ampadu.
17. In Vitro Analysis of Combined Analgesics: Paracetamol, Ibuprofen and Caffeine on the Ghanaian Market. Priscilla Ansomaa Nyarko.
18. In Vitro Drug Analysis of some Drugs Containing a Combination of Paracetamol and Diclofenac Sodium on the Ghanaian Market. Nathan Kwabena Coomson.
19. Evaluating the Quality of Different Brands of 2.5 mg Bendroflumethiazide Tablets Sold on the Ghanaian Market. Maame Akua Serwaah Sarpong.
20. In Vitro Analysis of Metformin Hydrochloride Tablets Sold on the Ghanaian Market. Anna Rosa Afful.
21. Antimicrobial and Antioxidant Activities and Phytochemical Screening of the Polar Extract of the Bark of Drypetesau brevillei. Ronald Amankwa Bonsu.
22. In Vitro Drug Analysis of Folic Acid Tablets on the Ghanaian Market. Anin Margaret.
23. In Vitro Analysis of Ciprofloxacin Hydrochloride Tablet Sampled from the Ghanaian Market. Jemima Damtse.

Supervision of Student project work / theses / research

1. Number of undergraduate students’ project supervised – 31 (2018/2019)
2. Number of postgraduate students’ (Ph.D.) project supervised – 1 (2018/2019)
3. Number of postgraduate students’ (Ph.D.) project supervised – 1 (2018/On going)
4. Number of undergraduate students’ project supervised – 24 (2019/On going)

Summary of Courses Taught from Nov. 2017 - date

Professionally related experience

1. Team leader in the extraction, isolation, purification, identification, characterization, process development and optimization of medicinal plant extracts targeting the treatment of HIV, pancreatic cancer and diabetic diseases.
2. Fully synthesized and characterization of quinazolinone hit compounds as inhibitors of PARP-1, poly(ADP-ribose)polymerase exhibiting ~60-80 nM activity.
3. Fully synthesized and characterization of korormicin derivatives which has an inhibitory activity towards the growth of marine Gram-negative bacteria.
4. Fully synthesized and characterization of hundreds of novel hit compounds of phenyl-indeno-pyrimidin derivatives as optimized adenosine A_2A/A₁ receptor antagonists targeting the treatment of Parkinson’s disease (a collaborative CRO with Janssen Pharmaceuticals, Inc.).
5. Team leader at CanAm in the design, synthesis, purification, identification and characterization of organic synthesis and medicinal chemistry research, chemical libraries, fee-for-service projects, custom chemical synthesis services, process development, optimization, scale-up of chemical intermediates and target compounds.
6. Team leader in design, synthesis, purification, and identification of new small molecule libraries, scaffolds, building blocks, templates, chemical arrays and new chemical targets for infectious, neurodegenerative, cardiovascular, and metabolic diseases, pain, inflammation as well as oncology for the various programs underway at ChemRoutes.
7. Involved in the synthesis and building of proprietary ChemKits and ChemCores as drug like ligands in the target areas of G-protein coupled receptors (GPCR), Kinase, and Ion channel based research.
8. Involved in the synthesis and building of proprietary ChemKits and ChemCores as drug like ligands in the target areas of G-protein coupled receptors (GPCR), Kinase, and Ion channel based research.
9. Synthetic efforts of miharamycin and ambruticin and its analogs in collaboration with Syngenta.

TEACHING EXPERIENCE

Kwame Nkrumah University of Science and Technology

2019 - 2020 Academic Year

2018 - 2019 Academic Year

2017 - 2018 Academic Year

Duties:

CHEM 254: Organic Reaction Mechanisms

Course Outline: 

• Organic reactions:

a) Substitution:

   -Nucleophilic substitution at saturated carbons.

  - Electrophilic and nucleophilic substitutions  in aromatic systems

b) Addition:

  - Electrophilic and nucleophilic addition to C=C and C=O

c) Elimination:

  - E1 and E2 mechanisms

d) Symmetry controlled reactions: electrocyclic, cycloaddition, and sigmatropic rearrangements.

• Carbonyl substitution reactions: including Aldol and Michael Addition reactions.
• Stereochemistry

CHEM 370: Practical Chemistry VI and Mini Project

University of Utah

Graduate Teaching Assistant, General Chemistry, Fall 2004, Spring 2005, and Spring 2006

Duties: Taught and supervised general chemistry laboratories and assisted in preparation and administration of examinations. Graded examinations, laboratory reports and answered undergraduate students’ questions. I also served as a help-session GTA to discuss with students their in-class performance, study skills, and to address questions concerning course materials. I maintained excellent GTA evaluations.

University of Alberta

Graduate Teaching Assistant, Help-Session, Organic Chemistry, Fall 2003

Graduate Teaching Assistant, Organic Chemistry, Fall and Winter 2000, Fall and Winter 2001, Fall and Winter 2002

Duties: Taught and supervised introductory organic chemistry laboratories and assisted in preparation and administration of examinations. Graded examinations, laboratory reports, mid-term examinations and answered undergraduate students’ questions. I maintained excellent GTA evaluations.

2018 – 2019 Academic Year Teaching Duties

CHEM 153: Basic Organic Chemistry I

• Molecular composition and structure of organic compounds

            – Determination and calculation of empirical and molecular formulae
            – Pictorial treatment of hybridization

• Organic Reactions

            – Bond formation and fission
            – Classification of reagents and reactions
            – Reaction intermediates: Carbocations, Free radicals, Carboanions

• Hydrocarbons: (Aliphatic, alicyclic and aromatic)

            – Structure and nomenclature
            – Homologous series and gradation of properties
            –  Preparation
            –  Reaction

CHEM 353: Organic Synthesis and Spectroscopy

• Selected organic reactions
• Methods in organic synthesis
• Organic Spectroscopy: NMR, IR, UV, Mass Spectroscopy – Principles/Application

CHEM 475: Modern Trends in Organic Chemistry

• Stereoselective reactions; the use of organometallic compounds in the synthesis of processing inaccessible organic compounds.
• Design of organic reactions and drug design

CHEM 369: Practical Chemistry V