1. Natural product extracts derived from understudied terrestrial plants and pure cultured local fungi are evaluated for anti-microbial, anti-inflammatory and anti-oxidant bioactivities.

2. Exploring phytochemical synergy as an additional alternative mechanism for the evocation of bioactivity of natural product extracts. Synergy-mediated bioassay-guided fractionation of bioactive constituents will be conducted to identify and structurally characterize compound synergists with selective bioactivities.