Seth is a Lecturer in the Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology (KNUST), Ghana. He is a certified Medical Laboratory Scientist by the Allied Health Professions Council, Ghana, and has over a decade of clinical laboratory practice before joining KNUST.

Seth holds a BSc in Medical Laboratory Technology and an MPhil in Immunology from KNUST. In addition, he has a PGDip in Teaching and Learning in Higher Education from the University of Education Winneba, Ghana. Moreover, he was a WACCBIP-DELTAS PhD Fellow and graduated with a PhD in Molecular Cell Biology of Infectious Diseases from the University of Ghana, Legon. His professional mission is to use the knowledge and skills acquired in immunology and molecular cell biology to bring about an increased impact on healthcare interventions in sub-Saharan Africa, specifically malaria and chronic viral hepatitis B infection elimination.

He is the Leader of the budding Seth Agyei Domfeh (SEAD) Laboratory, focusing on understanding the mechanisms underlying malaria parasite gametocytogenesis and hepatocellular carcinogenesis and discovering natural products with activities against malaria parasite gametocytes, hepatitis B virus, and hepatocellular carcinoma.

Seth teaches undergraduate and postgraduate courses that include cell biology, molecular biology, biomolecular techniques, and molecular medicine.