Seth has over eighty citations and an h-index of five, based on Google Scholar and ResearchGate metrics. Check his publications on Google Scholar. Below are selected interesting findings from his publications:

Hepatitis B virus (HBV) infection is among the commonest chronic infections worldwide, with an estimated 300 million persons chronically infected, and the leading cause of hepatocellular carcinoma (HCC). HCC is highly aggressive, typically diagnosed at an advanced stage worldwide, especially in Africa, with a poor survival rate. Interestingly, in Africa, pegylated interferons and tenofovir disoproxil fumarate, first-line agents in treating chronic HBV infection, are inaccessible due to their high cost. Also, the continuous use of interferons in patients with chronic HBV infection leads to myriad adverse effects. Consequently, there is a need for other cheaper sources of therapies that are less toxic and readily available in resource-limited countries, like Ghana. Notably, we showed that cryptolepine (one of the alkaloids in the medicinal plant Cryptolepis sanguinolenta) mimics interferons and could be used to manage chronic HBV infection. Moreover, we have established that cryptolepine and Nibima (now Mibima, an aqueous herbal preparation from C. sanguinolenta for managing malaria in Ghana) inhibit HBV replication; therefore, Mibima could be studied for managing chronic HBV infection in resource-limited countries since over 80% of people in these countries depend on herbal medicine.

Microscopic identification of Plasmodium spp. is the gold standard for malaria diagnosis. Yet, malaria rapid diagnostic test kits are also available for prompt diagnosis in settings with limited microscopists. We evaluated four routinely used malaria rapid diagnostic test (RDT) kits at the Enyiresi Government Hospital in the Eastern Region, Ghana. Blood samples were collected to identify P. falciparum using microscopy. Also, the performances of First Response Malaria Ag Pf, Carestart Malaria Pf, SD Bioline Ag Pf, and ABON Malaria Pf were evaluated using the results from the microscopy as the reference. All four malaria RDT kits had sensitivities and specificities over 75% compared to the microscopy results. However, the SD Bioline Ag Pf kit recorded the highest agreement with microscopy (Cohen’s kappa = 0.879). Although all four malaria RDT kits performed remarkably well and can be used in emergencies, the results from these RDT kits need to be confirmed by microscopy.

Ceiba pentandra (L.) Gaertn. (Malvaceae) is traditionally used in Africa to manage a variety of medical conditions, including cancer. The hydroethanolic extract of the leaves of C. pentandra has been shown to possess antiproliferative activity. However, the fractionation of antiproliferative bioactive constituents from the leaves of C. pentandra and the determination of the mechanisms of action of such bioactive constituents remain unexplored. We, therefore, fractionated the extract of C. pentandra leaves, established the antiproliferative activities of the fractionated constituents, and determined the active constituents’ possible mechanisms of action. Remarkably, one isolate significantly exhibited antiproliferative activities against four cancer cell lines, including hepatocellular carcinoma, colorectal adenocarcinoma, cervical carcinoma, and mammary adenocarcinoma. Also, this isolate significantly increased the levels of phosphorylated cyclin-dependent kinase 2 (Cdk2 pTyr15), a key regulator of cell cycle arrest, and cleaved poly [ADP-ribose] polymerase 1 (PARP1), a hallmark of apoptosis initiation. These findings underscore the therapeutic potential of this isolate in cancer treatment.

Candida albicans is the leading cause of candidiasis, predominantly among women with urogenital candidiasis. Since most people in resource-limited countries depend on herbal medicine for their primary healthcare needs, many herbal drugs are sold to manage various diseases. We evaluated the anti-C. albicans activities of five herbal preparations indicated for treating candidiasis sold at the Kumasi Central Market in the Ashanti Region, Ghana. The herbal preparations were tested against clinically isolated C. albicans using the Kirby-Bauer disc diffusion antimicrobial susceptibility test. Fluconazole, a standard antifungal drug, was included in the evaluation as a positive control. Among the five selected herbal preparations, only one was effective against C. albicans. This herbal drug was prepared from Centella asiatica sap, Turnera microphylla leaves, and Vitex agnus-castus leaves. Our findings suggest that not all herbal preparations on the market are effective, emphasising the need for authorities to continually check the effectiveness of these preparations on the market.