Prof. Isaac Ayensu

Professor

Dept: Pharmaceutical Chemistry
Room C307, Third Floor, Tackie Building
Department of Pharmaceutical Chemistry
Faculty of Pharmacy KNUST
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Research Areas/Interests

Pharmaceutical analysis, characterization and quality control, Novel drug formulation and development. Medicinal Chemistry Novel Application of h...~more

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Publications

    Book Chapter

     

    1. Boateng J, Ayensu I, Pawar H. (2014). Chitosan in: Khutoryanskiy (Editor). Mucoadhesive Materials and Drug Delivery Systems John Wiley and Sons Ltd, West Sussex, United Kingdom. ISBN 9781119941439. 235-254.

    Recent Publications in peer reviewed journals

     

    1. Turkson, B. K., Nketia, R. I., Frimpong, C, K., Mensah, K, S.,   Sarfo, A, S., Safo, O, N., Bekoe, B, O., Ayensu, I., Mensah, M, L, K., & Zoiku, F. (2024). Antiplasmodial activity and toxicity of the leaves, stem and roots of Parinari robusta Oliv [CHRYSOBALANACEAE] in animal model. South African Journal of Botany 168, 71-76
    2. Brobbey, A., Adu-Brimpong, B., Addotey, J. N., Asare-Nkansah, S., Ayensu, I, Appiah, E., & Derizie Alexander (2023). Caffeine Content in Energy Drinks can be Determined using a Validated Liquid-Liquid Extraction Method Coupled to UV-Visible Spectrophotometry. Nutri Food Sci Int J. 12(2):555834. DOI: 10.19080/NFSIJ.2023.12.555834
    3. Alolga, R.N., Ayensu, I., Sosu, J.S. (2023). Forced degradation studies, elucidation of degradation pathways and degradation kinetics of Xylopic acid via LC and LC-MS/MS analyses. Journal of Pharmaceutical Sciences (In Press)
    4. Alolga, R.A., Wang, S., Ayensu, I., &Nebeolisa, C.S. (2022) Pharmacokinetics and in vitro liver microsomal enzyme metabolism of Xylopic acid Journal of Pharmaceutical and Biomedical Analysis 224: 115200 https://doi.org/10.1016/j.jpba.2022.115200
    5. Douvris, , Bentil, E., Ayensu, I., Osei Akoto, C., Amponsah, I.K., Adu, J., & Bussan, D. (2022). Trace Metals in Cannabis Seized by Law Enforcement in Ghana and Multivariate Analysis to Distinguish among Different Cannabis Farms. Toxics. 10, 567. https://doi.org/10.3390/toxics10100567 
    6. Amengor, C.D.K., Brobbey, A., Ayensu. I., Orman, E., Peprah, P., Abudey, B.M., Ayibi, S.J., Attoh, C.N.D., Ade, A., Sodzi, P.K., & Aboagye, J.S. (2022). Acid-Base Indicator Properties of Synthesized Phenylhydrazones: 4-(2-(2,4-Dinitrophenyl) Hydrazono) Methyl)-2 Methoxy Phenol and 4-(2-(2,4-Dinitrophenylhydrazono) Methyl) Benzene-1,3-diol. Journal of Chemistry, Volume 2022, Article ID 3667814, 9 https://doi.org/10.1155/2022/3667814
    7. Tordzagla, N., Ayensu, I., & Ofori, M.F. (2022). In vivo and in vitro antiplasmodial activity of extracts, fractions and an isolated compound from silk of zea mays (corn silk). Journal of Medical Pharmaceutical and Allied Sciences, 11(3), 4810-4816. DOI: 10.55522/jmpas.V1112.3160
    8. Mensah, J. N., Brobbey, A. A., Addotey, J. N., Ayensu, I., Asare-Nkansah, S., Opuni, K. F. M., & Adutwum, L. A. (2021). Ultraviolet-Visible Spectroscopy and Chemometric Strategy Enable the Classification and Detection of Expired Antimalarial Herbal Medicinal Product in Ghana, International Journal of Analytical Chemistry, vol. 2021, Article ID 5592217, 9 pages, https://doi.org/10.1155/2021/5592217
    9. Quartey, A. K., Ayensu, I., Orman, E., Mireku-Gyimah, N. A., Jibira, Y., & Goku, P. E. (2021). In-vivo anti-inflammatory activity of different parts of Adansonia Digitata. Journal of Medicinal Plants Research, 15(6), 252-259. DOI: https://doi.org/10.5897/JMPR2020.7079
    10. Quartey, A. K., Jibira, Y., Forkuo-Donkor, A., Ayensu, I., Oduro-Kwarteng, A, A., Asuamah, S E., Noah, P. (2020). Hydroethanolic stem bark extract of Vernonia amygdalina Del. (Asteraceae) suppresses yeast induced pyrexia and Plasmodium berghei malaria in murine models. Journal of Medicinal Plants Research. 14(6):258-264. DOI: 10.5897/JMPR2020.6931
    11. Ade, A., Amengor, C. D. K., Brobbey, A., Ayensu, I., Harley, B. K., & Boakye, Y. D. (2020). Synthesis and Antimicrobial Resistant Modulatory Activity of 2,4-Dinitrophenylhydrazone Derivatives as Agents against Some ESKAPE Human Pathogens. Journal of Chemistry 2020, Article ID 2720697, 9 pages https://doi.org/10.1155/2020/2720697
    12. Ayensu, I., Bekoe, S.O., Adu, J.K., Brobbey, A.A., Appiah, E. (2020). Evaluation of Acid Neutralising and Buffering Capacities of selected Antacids in Ghana, Scientific African, doi: https://doi.org/10.1016/j.sciaf.2020.e00347.
    13. Amenu, J. D., Ayensu, I., Bekoe, S. O., Yamoah, A. (2019) Characterization And Rp-Hplc Method Development of a Biomarker (Bergenin) from the roots of Securinega virosa. Journal of Basic and Applied Research International. 25(6): 358–367.
    14. Danson, D., Ehoneah, O., Ayensu, I., Brobbey, A. A., Adu, J. K., Bekoe, S. O. (2019) Determination of Tryptophan Content in Hausa Koko (Spicy Millet Porridge): A Ghanaian Beverage. International Journal of Phytopharmacy; 9(4): e5287. Doi: 10.7439/ijpp.v9i4.5287
    15. Adu, J.K., Dzakadzie, F., Orman, E., Ayensu, I., Amengor, C.D.K., Kwofie S. (2019) Assessing metal contaminants in milled maize products available on the Ghanaian market with Atomic Absorption Spectrometry and Instrumental Neutron Activation Analyser techniques. Food Control 109.
    16. Yir-Erong B, Bayor MT, Ayensu I, Gbedema SY & Boateng JS. (2019) Oral thin films as a remedy for noncompliance in pediatric and geriatric patients. Ther. Deliv.
    17. Yir-Erong, B., Bayor, M.T., Ayensu, I., Gbedema, S.Y., Boateng, J. (2018). The Challenges and Knowledge Gaps in Malaria Therapy: A Stakeholder Approach to Improving Oral Quinine Use in the Treatment of Childhood Malaria in Ghana. Journal of Pharmaceutics, vol. 2018, Article ID 1784645, 12 pages, https://doi.org/10.1155/2018/1784645.
    18. Opoku, S., Ayensu, I., Brobbey, A.A., Adjavon, K.A. (2018). Metronidazole Analysis: Method Development and Validation via Hydrotropic Solubilization. International Journal of Pharmacy and Pharmaceutical Research (Human Journals); 12(4): 1-13.
    19. Tordzagla N, Adosraku RK, Ayensu I, Aseidu-Larbi J, Ocloo A, Ofori MF, Antwi S. (2018) In vivo antiplasmodial activity of extracts of selected Ghanaian medicinal plants. Investigational Medicinal Chemistry and Pharmacology 1(2):12. doi: 10.31183/imcp.2018.00012
    20. Ayensu, I., Adu, J. K., & Boateng, J. S. (2017). Stability evaluation of protein drugs in optimised thiolated-chitosan based buccal xerogels. Journal of Science and Technology. 37(3): 46-53.
    21. Mintah DN, Quartey AK, Oppong AB, Ayensu I, Apenteng JA. (2017). Synergistic in-vitro anthelmintic potentials of vernonia amygdalina delile stem and carica papaya lin. Seeds. World Journal of Pharmacy and Pharmaceutical Sciences 6 (10): 103-115.
    22. Brobbey AA., Somuah-Asante S., Asare-Nkansah S., Osei BF., Ayensu I. (2017). Preliminary phytochemical screening and scientific validation of the anti-diabetic effect of the dried husk of Zea mays (Corn, Poaceae). International Journal of Phytopharmacy, 7 (1): 01-05.
    23. Adu J.K., Amoah E., Ayensu I., Osei-Djarbeng S. and Jagri P. (2016). Phytochemical Screening and antimicrobial activities of the stem bark of Allanblackia parviflora chev (Clusiaceae). The Journal of Phytopharmacology, 5 (6): 215-224.
    24. Ayensu I., Doe , Brobbey A.A., Adosraku R. (2016). Assessment of bioequivalence profile of locally produced flucloxacillin sodium capsules via urinary excretory rates. Journal of Science and Innovative research. 5(4): 125-129.
    25. Ayensu I., Quartey A.K. (2015). Phytochemical screening and in-vitro antioxidant properties of the stem Bark of TrichiliaTessemannii (Hams) (Meliaceae). World Journal of Pharmacy and Pharmaceutical Sciences. 4 (3), 76-90.
    26. Brobbey A.A., Quartey A.K., Otuo-Serebour S., Ayensu I. (2015). Determination of the phytochemical constituents, antimicrobial and antitussive activities of the leaves of Solanum torvum (Swartz). World Journal of Pharmacy and Pharmaceutical Sciences. 5 (1), 1363-1375.
    27. Ayensu I., Quartey A.K. (2015). Antimicrobial activities of the stem bark of TrichiliaTessemannii (Hams) and Trichilia Monadelpha (Thonn) J.J. de Wilde both of the family Meliaceae. World Journal of Pharmacy and Pharmaceutical Sciences. 4 (9), 1351-1362.
    28. Ofori-Kwakye, K., Ayensu, I., Akyina, B., Kipo, S.L., Boakye-Gyasi, M.E. (2014). Adulteration of Ghanaian Topical Herbal Preparation with Dexamethasone. World Journal of Pharmacy and Pharmaceutical Science. 3 (6), 134-141.
    29. Boateng, J.S,, Mitchell, J.C., Pawar, H., Ayensu, I.(2014). Functional Characterisation and Permeation Studies of LyophilisedThiolated Chitosan Xerogels for Buccal Delivery of Insulin. Peptide and Protein Letters 21 (11), 1163-1175.
    30. Pawar, H. Boateng J.S., Ayensu, I., and Tetteh, J. (2014). Multifunctional medicated lyophilised wafer dressing for effective chronic wound healing. Journal of Pharmaceutical Sciences. 103(6) 1720 - 1733.
    31. Boateng, J. and Ayensu, I. (2014). Preparation and characterisation of laminated thiolated chitosan-based freeze-dried wafers for potential buccal delivery of macromolecules. Drug Development and Industrial Pharmacy. 40(5), 611-618.
    32. Giovino, C., Ayensu, I., Tetteh, J. Boateng. J. (2013). An integrated buccal delivery system combining chitosan films impregnated with peptide loaded PEG-b-PLA nanoparticles. Colloids and Surfaces B: Biointerfaces. 112, 9-15.
    33. Kianfar, F., Ayensu, I., Boateng, J. (2013). Development and physico-mechanical characterization of carrageenan and poloxamer based lyophilized polymeric matrix as a potential buccal drug delivery system. Drug Development and Industrial Pharmacy. 40 (3) 361-369.
    34. Ayensu, I., Boateng, J.S. (2012). Development and evaluation of lyophilized thiolated-chitosan wafers for buccal delivery of protein. Journal of Science and Technology. 32 (2), 46-55.
    35. Ayensu, I., Mitchell, J.C., Boateng, J.S. (2012). Effect of membrane dialysis on characteristics of lyophilised chitosan wafers for potential buccal delivery of proteins. International Journal of Biological Macromolecules. 50, 905–
    36. Ayensu, I., Mitchell, J.C., Boateng, J.S. (2012). In vitro characterisation of chitosan based xerogels for potential buccal delivery of proteins. Carbohydrate Polymers. 89, 935–
    37. Giovino, C., Ayensu, I., John Tetteh, J., Joshua S. Boateng, J.S. (2012). Development and characterisation of chitosan films impregnated with insulin loaded PEG-β-PLA nanoparticles (NPs): A potential approach for buccal delivery of macromolecules. International Journal of Pharmaceutics. 428, 143–
    38. Ayensu, I., Mitchell, J.C., Boateng, J.S. (2011). Development and physico-mechanical characterisation of lyophilised chitosan wafers as potential protein drug delivery systems via the buccal mucosa. Colloids and Surfaces B: Biointerfaces. 91, 258–
    39. Ayensu, I., Mitchell, J.C., Boateng, J.S. (2011). Formulation and evaluation of lyophilisedthiolated chitosan wafers for buccal mucosal delivery of proteins. The AAPS Journal, 13 (S2). M1144-M1144.
    40. Ayensu, I., Mitchell, J.C., Boateng, J.S. (2010). Freeze-dried thiolated chitosan formulations for protein delivery via the buccal mucosa. Journal of Pharmacy and Pharmacology. 62 (10), 1273-1274.
    41. Ayensu, I., Mitchell, J.C., Boateng, J.S. (2010). Novel lyophilisation cycle development of chitosan based formulations for buccal delivery using paracetamol as model drug. The AAPS Journal. 12 (S2), W4170-
    42. Ayensu I. Okine N. N. A. (2008). Determination of Relative Bioavailability of Paracetamol tablets using urinary excretory data. The Ghana Pharmaceutical Journal. 33 (2): pp 9-18.

     

    Conferences proceedings

    1. Turkson, B.K., Mensah M. L. K., Ayensu, I. & Amponsah, I. K. (2021). Toward collaboration to improve the itegration of traditional and orthodox medicine for holistic healthcare delivery in Ghana. 9th Biennial Scientific conference of the College of Health Sciences, KNUST. Poster No. 44.
    2. Ayensu I, Bekoe S.O. Adu J.K, Brobbey A.A, Appiah E. (2019). Evaluation of Acid Neutralizing and Buffering Capacity of Selected Antacids in Ghana. AGM of Pharmaceutical Society of Ghana, Accra.
    3. Ade A., Brobbey AA, Ayensu I, Amengor C, Adu JK. (2019). Synthesis and antimicrobial activities of 2,4-Dinitrophenylhydrazone derivatives. Pharmacy Graduate Students’ week. Poster No. PP004.
    4. Quartey AK, Ayensu I. (2019). Anti-inflammatory properties of various parts of Adansonia digitate (Malvaceae). Pharmacy Graduate Students’ week. Poster No. PP005.
    5. DansonD, Ehoneah O, Ayensu I, Brobbey AA, Adu JK, Oppong Bekoe SO. (2019). Qualitation and quantification of Tryptophan in Hausa Koko (Spicy millet porridge): A Ghanaian Beverage. Pharmacy Graduate Students’ week. Poster No. PP019.
    6. Amenu JD, Ayensu I, Bekoe SO, Ahimsa Y. (2019). Characterization and RP-HPLC method development of a Biomarker (Bergenin) from the roots of Securinega Virosa Pharmacy Graduate Students’ week. Poster No. PP021.
    7. Safrega B, Ayensu I. (2019). Development and validation of stability indicating HPLC method for simultaneous estimation of Paracetamol, Ibuprofen and caffeine in drug formulation. Pharmacy Graduate Students’ week. Poster No. PP038.
    8. Ayensu I., Agyeman S., Appiah E., Jackson E. (2017). Hydrotropic solubilization method for the analysis of furosemide in pure powders and formulated tablets. BSU II Conference, Kumasi. Poster No. H7
    9. Ayensu I, Quartey (2015). Phytochemical, antimicrobial and antioxidant constituents of trichilia monadelpha (thonn) j.j. de wilde and trichilia tessemannii(harms) both of the family meliaceae. Postgraduate day, Faculty of Pharmacy and Pharmaceutical Sciences, KNUST. Poster No. 31
    10. Quartey AK, Ayensu I. (2014).Antimicrobial activities of the stem bark of trichiliamonadelpha (thonn) j.j. de wilde both of the family meliaceae. 7thAnnual Research Conference, Graduate Students Association of Ghana, KNUST. Poster No. 7.
    11. Quartey AK, Ayensu I. (2014).Antimicrobial activities of the stem bark of trichiliatessemannii(harms) of the family meliaceae. Workshop on Medicinal Plant Research. Nugochi Memorial insitutute for medical Research and SATRPS (JICA/JST). Poster no. 1
    12. Pawar H, Ayensu I, Tetteh J, Boateng J.(2013).Sodium alginate based antimicrobial wound dressings for chronic wound healing. 1st Hydrocolloids Symposium, University of Huddersfield, UK.
    13. Ayensu I., Mitchell J.C., Boateng J.S. (2012). Development of laminated chitosan based lyophilized xerogels for potential buccal delivery of macromolecules. - APS (UKPharmSci), Nottingham UK. Abstract number 42.
    14. Ayensu, I., Mitchell, J.C. and Boateng, J.S. (2012). In-vitro permeation studies of insulin using lamb buccal tissue and Epi-oralTMbuccal tissue construct. APS (UKPharmSci), Nottingham UK. Abstract number 60.
    15. Ayensu I., Mitchell J.C., Boateng J.S. (2012). Evaluation of enzyme inhibitors on laminated thiolated chitosan xerogels for buccal delivery of insulin. AAPS, USA. Abstract I.D. AM-12-01660.
    16. Ayensu I., (2012). Development of novel formulations for mucosal delivery of protein based drugs. University of Greenwich.
    17. Ayensu, I., Mitchell, J.C. and Boateng, J.S. (2011). Development and Characterisation of lyophilised chitosan wafers: effect of membrane dialysis. APS (UKPharmSci), Nottingham UK. Abstract number 59.
    18. Ayensu, I., Mitchell, J.C. and Boateng, J.S. (2011). Formulation and evaluation of lyophilisedthiolated wafers for buccal mucosa delivery of proteins. AAPS Journal, 13 (S2).
    19. Ayensu, I., Mitchell, J.C. and Boateng, J.S. (2011). Characterisation and evaluation of lyophilised chitosan (CS) wafers for protein delivery via the buccal mucosa. APS (UKPharmSci), Nottingham UK. Abstract number 43.
    20. Ayensu, I., Mitchell, J.C. and Boateng, J.S. (2010). Freeze dried thiolated chitosan formulations for protein delivery via the buccal mucosa. APS (UKPharmSci), Nottingham UK. Abstract number 42.
    21. Buabeng KO, Ayensu I, Mensah KB, Owusu-Ofori A, Bekoe SO, Boakye-Gyasi E, Anto BP, Mantey P, Adu OA. (2017)Assessing water quality in the Asante Akim Districts in Ghana. BSU II Conference, Kumasi. Poster No. H2
    22. Ayensu I, Amoah , Adjavon KA, Osei-Djarbeng S, Adjei E. (2017) Anti-oxidant activities of the stem bark of Allanblackia parviflora Chev. (clusiaceae). BSU II Conference, Kumasi. Poster No. C21.
    23. Ayensu I., Mitchell J.C., Boateng J.S. (2010).Freeze dried thiolated chitosan formulations for protein delivery via the buccal mucosa.School of Science, The University of Greenwich at Medway, Chatham Maritime, ME4 4TB, UK.
    24. Ayensu, I., Mitchell, J.C. and Boateng, J.S. (2010). Novel lyophilization cycle development of chitosan-based formulation for buccal delivery using paracetamol as a model drug. AAPS PharmSciTech, W4170

    Podium presentations

    1. Quartey, A. K., & Ayensu, I. (2021). Toxicity and In-vivo anti-inflammatory activity of different parts of Adansonia digitate. 9th Biennial Scientific conference of the College of Health Sciences, KNUST. Oral Presentation 15.
    2. Agbetiameh, B.K., Essel, E., & Ayensu, I. (2020). Public health risks and content evaluation of hydroquinone containing creams. COBREG 2020 Virtual conference. 19/11/2020.
    3. Ayensu, I, Bekoe, S. O., Adu J. K., Brobbey, A. A., & Appiah, E. (2019). Evaluation of Acid Neutralizing and Buffering Capacity of Selected Antacids in Ghana. AGM of Pharmaceutical Society of Ghana, Accra.
    4. Tordzagla, N., Adosraku, R. K., Ayensu, I., Asiedu-Larbi, J., Ocloo, A., Fokuo, O. M., & Antwi, S. (2019). In-vivo antiplasmodial activity of extracts of selected Ghanaian medicinal plants. Pharmacy Graduate Students’ week. OP013.
    5. Bekoe, S. O., Ayensu, I., Buabeng, K. O., Boaky- Gyasi, E., Mensah, K. B., & Adu, A. (2017) Detection of pharmaceutical contaminants in water sources in two peri-urban communities in Ghana. BSUII Research Conference, Kumasi
    6. Ayensu I., Agyeman, S., Aryee, K.A. (2017) Development and validation of novel method of analysis of metronidazole via hydrotropic solubilization. BSUII Research Conference, Kumasi
    7. Quartey K and Ayensu I. (Aug, 2014) Phytochemical, antimicrobial and antioxidant constituents of trichiliamonadelpha (thonn) j.j. de wilde and trichiliatessemannii(harms) both of the family meliaceae. Scientific session of Annual General Meeting (A.G.M.). Pharmaceutical Society of Ghana.
    8. Ayensu I., Mitchell J.C., Boateng J.S. (2012). Development of laminated chitosan based lyophilized xerogels for potential buccal delivery of macromolecules. - APS (UKPharmSci)
    9. Ayensu I., Mitchell J.C., Boateng J.S. (2011). Characterisation and evaluation of lyophilized chitosan wafers for protein delivery via the buccal mucosa. APS (UKPharmSci)
    10. Ayensu I., Banning K. and Debrah P. (August, 2008) - Promoting “NEW-START” (Nutrition, Exercise, Water, Sunlight, Temperance, Air, Rest and Trust in God) approach towards Regenerative Health. Scientific session of Annual General Meeting (A.G.M.) Pharmaceutical Society of Ghana.
    11. Okine N. N. A., Adosraku R. Ayensu I., and Baidoo S.P. Bioavailability assessment of some locally manufactured choroquine phosphate tablets. (August 2006). Scientific session of Annual General Meeting (A.G.M.). Pharmaceutical Society of Ghana.
    12. Okine N. N.  A. and Ayensu I. (August, 2004) Bio-availability Studies on Locally Manufactured Paracetamol Tablets, using urine samples. Scientific session of Annual General Meeting (A.G.M.) Pharmaceutical Society of Ghana

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