Dr. Lord Jephthah Joojo Gowans

Lecturer


Dept: Biochemistry and Biotechnology
TF2
Aboagye Menya Complex
College of Science
KNUST

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Research Areas/Interests

Genetic and environmental factors in the aetiology of human orofacial clefts   Molecular Genetics aetiology of craniosynostosis.  ...~more


Publications

    PEER-REVIEWED PUBLICATIONS

    • Alade A, Buxo-Martinez CJ, Mossey PA, Gowans LJJ, Eshete MA, Adeyemo WL, Naicker T, Awotoye WA, Adeleke C, Busch T, Toraño AM, Bello CA, Soto M, Soto M, Ledesma R, Marquez M, Cordero JF,Valle LML-D, Salcedo MI, Debs N, Li M, Petrin A, Olotu J, Aldous C, Olutayo J,  Ogunlewe MO,  Abate F, Hailu T, Mohammed I, Gravem P, Deribew M, Gesses M, Hassan M, Pape J, Adeniya OA, Obiri-Yeboah S, Arthur FKN, Oti AA, Olatosi O, Miller SE, Donkor P, Dunnwald MM,  Marazita ML, Adeyemo AA, Murray JC, Butali A. (2020). Non-Random Distribution of Deleterious Mutations in the DNA and Protein Binding Domains of IRF6 are Associated with Van Der Woude Syndrome. Mol Genet Genomic Med.; 8:e1355. Doi.org/10.1002/mgg3.1355.
    • Sweat YY, Sweat M, Mansaray M, Cao H, Eliason S, Adeyemo WL, Gowans LJJ, Eshete MA, Anand D, Chalkley C, Saadi I, Lachke SA, Butali A, Amendt BA. (2019). Six2 regulates Pax9 expression, palatogenesis and craniofacial bone formation. Developmental Biology; 458(2020): 246–256. Doi:10.1016/j.ydbio.2019.11.010.
    • Gowans LJJ, Cameron-Christiea S, Slayton RL, Busch TD, Romero-Bustillos M, Eliason S, Sweat M, Sobreira N, Yu W, Kantaputra PN, Wohler E, Adeyemo WL, Lachke S, Anand D, Campbell C, Drummond BK, Markie DM, van Vuren WAJ, van Vuren LJ, Casamassimo PS, Ettinger R, Owais A, van Staden IP, Amendt BA, Adebowale AA, Murray JC, Robertson SP, Butali A. (2019). Missense Pathogenic variants in KIF4A Affect Dental Morphogenesis Resulting in X-linked Taurodontism, Microdontia and Dens-Invaginatus. Frontiers in Genetics; 10:800. Doi: 10.3389/fgene.2019.00800.
    • Acheampong AO, Addison W, Obiri-Yeboah S, Amuasi A, Gowans LJJ, Newman-Nartey M, Sabbah DK, Pare P, Selormey R, Baffour G, Larmie RNL, Oyakilome S, Atuwo-Ampoh R, Olesu J, Gyimah NT, Donkor P. (2019). The Rule of "10's" in the Management of Cleft Lip and Palate Children: The Komfo Anokye Teaching Hospital Experience. J Clin Res Den.; 2(1):1-4.
    • Butali A, Mossey PA, Adeyemo WL, Eshete MA, Gowans LJJ, Busch TD, Jain D, Yu W, Huan L, Laurie CA, Laurie CC, Nelson S, Li M, Sanchez-Lara PA, Magee WP, Magee KS, Auslander A, Brindopke F, Kay DM, Caggana M, Romitti PA, Mills JL, Audu R, Onwuamah C, Oseni GO, Owais A, James O, Olaitan PB, Aregbesola BS, Braimah RO, Oginni FO, Oladele AO, Bello SA, Rhodes J, Shiang R, Donkor P, Obiri-Yeboah S, Arthur FKN, Twumasi P, Agbenorku P, Plange-Rhule G, Oti AA, Ogunlewe OM, Oladega AA, Adekunle AA, Erinoso AO, Adamson OO, Elufowoju AA, Ayelomi OI, Hailu T, Hailu A, Demissie Y, Derebew M, Eliason S, Romero-Bustillous M, Lo C, Park J, Desai S, Mohammed M, Abate F, Abdur-Rahman LO, Anand D, Saadi I, Oladugba AV, Lachke SA, Amendt BA, Rotimi CN, Marazita ML, Cornell RA, Murray JC, Adeyemo AA. (2019). Genomic Analyses in African Populations Identify Novel Risk Loci for Cleft Palate. Hum Mol Genet.; 28(6):1038-1051. Doi: 10.1093/hmg/ddy402.
    • Oseni GO, Deepti J, Mossey PA, Busch TD, Gowans LJJ, Eshete MA, Adeyemo WL, Laurie CA, Laurie CC, Owais A, Olaitan PB, Aregbesola BS, Oginni F, Bello SA, Donkor P, Audu R, Onwuamah C, Obiri-Yeboah S, Plange-Rhule G, Ogunlewe OM,  Olutayo J, Halilu T, Abate F, Abdur-Rahman LO, Oladugba AV, Marazita ML, Murray JC, Adeyemo AA, Butali A. (2018). Identification of Paternal Uniparental Disomy on Chromosome 22 and a De-novo Deletion on Chromosome 18 in Individuals with Orofacial Clefts. Mol Genet Genomic Med.; 6(6):924-932. DOI:10.1002/mgg3.459.
    • Gowans LJJ, Oseni G, Mossey PA, Adeyemo WL, Eshete MA, Busch TD, Donkor P, Obiri-Yeboah S, Plange-Rhule G, Oti AA, Owais A, Olaitan PB, Aregbesola BS, Oginni F, Bello SA, Audu R, Onwuamah C, Agbenorku P, Ogunlewe MO, Lukman AR, Marazita ML, Adeyemo AA, Murray JC, Butali A. (2018). Novel GREM1 Variations in sub-Saharan African Patients with Cleft Lip and/or Cleft Palate. The Cleft-Palate Craniofac. J.; 55(5): 736-742. Doi: 10.1177/1055665618754948.
    • Gowans LJJ, Obiri-Yeboah S, Oti AA, Arthur FKN, Twumasi P, Agbenorku P, Plange-Rhule G, Donkor P. (2018). Non-random distribution of Human Orofacial Clefts in Ghana: Gene-environment interactions. Open Journal of Stomatology; 8(2):35-52. DOI: 10.4236/ojst.2018.82004.
    • Eshete MA, Liu H, Li M, Adeyemo WL, Gowans LJJ, Mossey PA, Busch T, Deressa W, Donkor P, Olaitan PB, Aregbesola BS, Braimah RO, Oseni GO, Oginni F, Audu R,  Onwuamah C, Olutayo J,  Augustine-Akpan E-A, Rahman LA, Ogunlewe MO, Arthur FKN, Bello SA, Agbenorku P, Twumasi P, Abate F, Hailu T, Demissie Y, Hailu A, Plange-Rhule G, Obiri-Yeboah S, Dunnwald MM, Gravem PE, Marazita ML, Adeyemo AA, Murray JC, Cornell RA, Butali A. (2018). Loss of Function GRHL3 Variants Detected in Africans with Cleft Palate. J Dent Res.; 97(1):41-48.  Doi: 10.1177/0022034517729819. Epub 2017 Sep 8.
    • Gowans LJJ, Busch TD, Mossey PA, Eshete MA, Adeyemo WL, Aregbesola B, Donkor P, Arthur FKN, Agbenorku P, Olutayo J, Twumasi P, Braimah R, Oti AA, Plange-Rhule G, Obiri-Yeboah S, Abate F, Hoyte-Williams PE, Hailu T, Murray JC, Butali A. (2017). The Prevalence, Penetrance and Expressivity of Aetiologic IRF6 variants in Orofacial Clefts Patients from sub-Saharan Africa. Mol Genet Genomic Med.; 5(2):164-171. DOI:1002/mgg3.273.
    • Liu H, Busch T, Eliason S, Anand D, Bullard S, Gowans LJJ, Nidey N, Petrin A, Augustine-Akpan E-A, Saadi I, Dunnwald M, Lachke SA, Zhu Y, Adeyemo A, Amendt B, Roscioli T, Cornell R, Murray J, Butali A. (2016). Exome Sequencing Provides Additional Evidence for the Involvement of ARHGAP29 in Mendelian Orafacial Clefting and Extends the Phenotypic Spectrum to Isolated Cleft Palate. Birth Defects Res.; 109(1):27-37. DOI:1002/bdra.23596.
    • Gowans LJJ, Adeyemo WL, Eshete M, Mosey PA, Busch T, Aregbesola B, Donkor P, Arthur FKN, Bello SA, Martinez A, Li M, Augustine-Akpan E-A, Deressa W, Twumasi P, Olutayo J, Deribew M, Agbenorku P, Oti AA, Braimah R, Plange-Rhule G, Gesses M, Obiri-Yeboah S, Oseni GO, Olaitan PB, Abdur-Rahman L, Abate F, Hailu T, Gravem P, Ogunlewe MO, Buxó CJ, Marazita ML, Adeyemo AA, Murray JC, Butali (2016). Association Studies and Direct DNA Sequencing Implicate Genetic Susceptibility Loci in the Etiology of Nonsyndromic Orofacial Clefts in Sub-Saharan African Populations. J Dent Res.; 95(11):1245-1256. DOI: 10.1177/0022034516657003. 
    • Darmstadt GL, Howson CP, Walraven G, Armstrong RW, Blencowe HK, Christianson AL, Kent A, Malherbe H,Murray JC, Padilla CD, Walani SR; Participant Working Group of the Dar es Salaam Seventh International Conference on Birth Defects and Disabilities in the Developing World. (2016). Prevention of Congenital Disorders and Care of Affected Children: A Consensus Statement. JAMA Pediatr.; 170(8):790-793. Doi: 10.1001/jamapediatrics.2016.0388.

     

    CONFERENCE PROCEEDINGS OR ABSTRACTS

    • Gowans LJJ, Arthur FKN, Busch TD, Murray JC, Donkor P, Sobreira N, Butali A. (July 2020). Co-occurrence of Orofacial Clefts and Clubfoot among Ghanaians: Whole Exome Sequencing implicates Multiple Syndromes and Genes. Poster/Oral Presentations, The 61st McKusick Short Course on Human and Mammalian Genetics and Genomics, The Jackson Laboratory, Bar Harbor, Maine, USA, Virtual Event.
    • Gowans LJJ. (July 2020). Elucidating Cleft Etiology Employing Multiplex and Twin Families (ElCEEMuTF). Oral Presentation, Noncommunicable Diseases Network Meeting organized by Fogarty International Center (FIC) of the National Institutes of Health (NIH), Virtual Event.
    • Olotu J, Duncan KM, Mossey PA, Wang T, Naicker T, Busch T, Awotoye W, Alade, A, Adeyemo WL, Gowans LJJ, Eshete MA, Adeleke C, Olatosi O, Li M, Miller SE, Hassan M, Pape J, Buxo-Martinez CJ, Adeyemo A, Murray JC, Cornell RA, Butali A. (March 2020). Functional and Sequencing Studies Identify ZNF750 as CPO Candidate Gene. Oral Presentation, 2020 IADR/AADR/CADR General Session & Exhibition, Washington, D.C., USA.
    • Alade A, Gowans LJJ, Eshete MA, Adeyemo WL, Naicker T, Awotoye WA, Adeleke C, Busch T, Li M, Olotu J, Hassan M, Pape J, Adeniyan OA, Olatosi O, Miller S, Butali A. (March 2020). Non-Random Distribution Of Deleterious Mutations In IRF6 Associated With Van Der Woude Syndrome. Poster Presentation, 2020 IADR/AADR/CADR General Session & Exhibition, Washington, D.C., USA.
    • Gowans LJJ, Donkor P, Obiri-Yeboah S, Oti AA, Arthur FKN, Busch T, Murray JC, Sobreira N, Butali A. (October 2019). Orofacial Clefts with Clubfoot Phenotypes in an African Population: Whole Exome Sequencing implicates Multiple Syndromes and Genes. Poster Presentation (Presenter), American Society of Human Genetics (ASHG) Annual Conference, Houston, Texas, USA.
    • Butali A, Gowans LJJ, Cameron-Christie S, Slayton RL,  Busch TD, Murray JC,  Robertson SP. (July 2019). Variants in KIF4A Affect Dental Morphogenesis Resulting in X-linked Taurodontism, Microdontia and Dens-Invaginatus. Oral Presentation, Gordon Research Conference: Craniofacial Morphogenesis and Tissue Regeneration, New London, New Hampshire, USA.
    • Awotoye WO, Gupta S, Busch TD, Park J, Dear A, Reid T, Buxo C, Gowans LJJ, Adeyemo WL, Eshete ME, Butali A. (February 2019). Targeted Sequencing of MRPL53 Identify Rare Missense Variants That Are Associated With Orofacial Clefts in Multiple Populations. Oral Presentation, Iowa Section of the America Association for Dental Research (AADR) 2019 Conference, Iowa City, Iowa, USA.
    • Gowans LJJ. (January 2019). Impact of Syndrome Diagnosis on Cleft Care. Oral Presentation (Presenter), Partners in African Cleft Training (PACT) workshop, KATH, Kumasi, Ghana.
    • Gowans LJJ, Mossey PA, Eshete MA, Adeyemo WL, Busch TD, Amendt B, Rotimi C, Marazita ML, Cornell RA, Adeyemo AA, Murray JC, Butali A. (November 2018). Genome-wide Association Studies, Imputation and Fine Mapping in African Populations Identify Novel Risk Loci for Orofacial Clefts. Oral Presentation (Presenter), Global Genomic Medicine Collaborative (G2MC) Annual Conference, Cape Town, South Africa.
    • Gowans LJJ, Cameron-Christie S, Slayton R, Busch TD, Romero-Bustillos M, et al. (September 2018). Missense Mutations in KIF4A Alter Dental Morphogenesis Resulting in X-Linked Taurodontism, Microdontia and Dens-Invaginatus. Oral Presentation (Presenter), Joint 12th Human Hereditary and Health in Africa (H3Africa) Consortium and 11th African Society of Human Genetics (AfSHG) Meetings, Kigali, Rwanda. Book of Abstracts
    • Butali A, Mossey PA, Gowans LJJ, Adeyemo WL, Eshete MA, Murray JC, Adeyemo AA. (July 2018). Novel Genome-wide Association Study Risk Loci for Nonsyndromic Orofacial Clefts. Oral Presentation, 96th International Association for Dental Research/Pan European Regional General Session and Exhibition, London, England.
    • Butali A, Mossey P, Gowans LJJ, Eshete MA, Adeyemo W, Busch T, Marazita M, Rhodes J, Murray J, Adeyemo A, Owais A. (April 2018). Genome-wide Analyses Identify One Significant and Seven Highly Suggestive New Loci for Orofacial clefts in the African Population. Oral Presentation, 75th Annual Conference of the American Cleft Palate-Craniofacial Association (ACPA), Pittsburg, Pennsylvania, USA. The Cleft Palate-Craniofacial Journal: 55(1S):58.
    • Butali A, Eshete MA, Adeyemo WL, Gowans LJJ, Busch TD, Oseni G, Marazita ML, Moseey PA, Murray JC, Adeyemo AA. (March 2018). Identification of Novel Candidate Genes in a Genome-wide Association study for Orofacial Clefts in sub-Saharan African Populations. Oral Presentation, 2018 AADR/CADR 47th Annual Meeting and Exhibition, Ft. Lauderdale, Florida, USA.
    • Petrin AL, Gowans LJJ, Mossey PA, Adeyemo WL, Eshete MA, Busch TD, Petrin RJ, Donkor P, Owais A, Marazita ML, Adeyemo AA, Murray JC, Butali A. (October 2017). Using GWAS Data to Identify Copy Number Variants Associated to Orofacial Clefts. Poster Presentation, 2017 Annual Meeting of the American Society of Human Genetics, Orlando, Florida, USA.
    • Butali A, Mossey P, Adeyemo L, Eshete M, Gowans LJJ, Busch T, Marazita ML, Murray JC, Adeyemo A. (October 2017). Genome-wide Analysis refine the Genetic architecture of Orofacial clefts and identifies novel risk loci in the African population. Poster Presentation, 2017 Annual Meeting of the American Society of Human Genetics, Orlando, Florida, USA.
    • Li M, Eshete M, Adeyemo W, Gowans LJJ, Busch T, Oseni G, Marazita M, Adeyemo A, Mossey P, Muray J, Butali A. (March 2017). Functional Characterization in Zebrafish of Human GRHL3 Mutations Associated with Cleft Palate in Sub-Saharan African Populations. Oral Presentation, 74th Annual Conference of the American Cleft Palate-Craniofacial Association (ACPA), The Broadmoor, Colorado Springs, Colorado, USA.
    • Li M, Adeyemo AA, Mossey PA, Cornell RA, Murray JC, Liu H, Eshete M, Busch T, Adeyemo WL, Gowans LJJ, Augustine-Akpan E-A, Oseni OG, Marazita ML, Butali A. (March 2017). Damaging Functional GRHL3 Mutations Identified in African Individuals with Cleft Palate. Oral Presentation, 2017 46th Annual Meeting of American Association for Dental Research, San Francisco, California, USA.
    • Eshete M, Liu H, Li M, Gowans LJJ, Mossey PA, Busch T, Augustine-Akpan E-A, Adeyemo W, Aregbesola B, Donkor P, Marazita M, Adeyemo A, Murray JC, Cornell R, Butali A. (October 2016). Functional Mutations in GRHL3 Gene are Associated with Cleft Palate in sub-Saharan Africans. Poster Presentation, 2016 Annual General Meeting of the American Society of Human Genetics, Vancouver, Canada.
    • Gowans LJJ. (July 2016). Genetic factors in the aetiology of cleft lip and palate in Ghana. Oral presentation (presenter), 1st National Conference on Cleft Lip and Palate, West African College of Physicians and Surgeons, Ridge, Accra, Ghana.
    • Gowans LJJ, Mossey P, Eshete M, Adeyemo W, Donkor P, Agbenorku P, Obiri-Yeboah S, Abate F, Hailu T, Murray JC, Butali A. (April 2016). Additional pathogenic IRF6 mutations in Van der Woude Syndrome from Sub-Saharan African populations. Oral Presentation, 73rd Annual Conference of the American Cleft Palate-Craniofacial Association (ACPA), Hilton, Atlanta, Georgia, USA.
    • Butali A, Adeyemo WL, Eshete MA, Gowans LJJ, et al. (March 2016). Etiologic Mutations in GRHL3 are associated with Cleft Palate in sub-Saharan African Populations. Poster Presentation, Gordon Research Conference and Seminar: Craniofacial Morphogenesis and Tissue Regeneration, Ventura, California, USA.
    • Gowans LJJ, Butali A, Adeyemo WL, Eshete MA, et al. (March 2016). Replication of Genome-wide Association Candidate Genes in Three sub-Saharan African Populations. Poster presentation, 45th Annual Meeting of American Association for Dental Research, Los Angeles, California, USA.
    • Butali A, Busch T, Gowans LJJ, Liu H, Anand D, Lachke SA, Nidey N, Amendt  B, Cornell R, Murray (October 2015). Exome sequencing in a Multiplex Family with Cleft Palate Only Identifies a Novel Damaging Mutation in ARHGAP29. Oral Presentation, 65th Annual General Meeting of the Society for Craniofacial Genetics and Developmental Biologists, Baltimore, Maryland, USA.

    ·   Gowans LJJ, Busch T, Mosey PA, Eshete M, Adeyemo W, Aregbesola B, Donkor P, Arthur FKN, Agbenorku P, Liu H, James O, Twumasi P, Bonde G,  Braimah R, Plange-Rhule G, Obiri-Yeboah S, Abate F, Hailu T, Cornell RA, Murray JC, Butali A. (September 2015). The Complex Penetrance and Expressivity of IRF6 Gene in the Aetiology of Syndromic and Nonsyndromic Human Orofacial Clefts in the African Population. Poster Presentation (Presenter), 7th International Conference on Birth Defects and Disabilities in the Developing World, Dar Es Salaam, Tanzania.

    • Gowans LJJ, Donkor P, Agbenorku P, Plange-Rhule G, Obiri-Yeboah S, Arthur FKN, Twumasi P, Murray JC, Butali A. (April 2015). Environmental factors contributing to genetic mutations in the pathogenesis of human orofacial clefts in Ghana. Poster presentation (Presenter), 72nd Annual Conference of American Cleft Palate-Craniofacial Association (ACPA), Palm Springs, California, USA.
    • Butali A, Busch T, Gowans LJJ, Murray JC, et al. (March 2015). Exome Sequence Analysis of a multiplex family with Cleft Palate Only. Oral Presentation, 93rd General Session of International Association for Dental Research, Boston, Massachusetts, USA.
    • Butali A, Busch T, Gowans LJJ, Murray JC, et al. (February 2015). Exome Sequence Analysis of a multiplex family with Cleft Palate Only. Oral Presentation, 62nd Annual Meeting of Iowa Section of the American Association for Dental Research, Iowa City, Iowa, USA.
    • Gowans LJJ, Twumasi P, Arthur FKN, Agbenorku P, Butali A, Donkor P, Murray JC. (April 2014). Significance of genetic mutations in the molecular pathogenesis of cleft lip, cleft palate and cleft lip and palate among selected cases in Ghana. Oral Presentation (Presenter), 3rd Annual Conference of Ghana Science Association, Ashanti Regional Chapter, KNUST, Kumasi, Ghana.

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