Prof. Caleb Kesse Firempong

Associate Professor

Dept: Biochemistry and Biotechnology
Faculty of Biosciences,
College of Science,
KNUST, Kumasi-Ghana.

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Research Areas/Interests

Current research focus is on lipid raft biomaterial for screening novel antitumor agents from natural sources. Major research interests also include c...~more



    [1] Adu Frimpong, M., Qiuyu, W., Firempong, C.K., Mukhtar, Y.M., Yang, Q. Omari Siaw, E., Lijun, Z., Xu, X. and Yu, J. Novel cuminaldehyde self-emulsified-nanoemulsion for enhanced antihepatotoxicity in carbon tetrachloride-treated mice. Journal of Pharmacy and Pharmacology, (2019). (SCI, IF = 2.39)

    [2] Zhu, Yuan, Wen Xu, Jiajia Zhang, Youwu Liao, Caleb Kesse Firempong, Michael Adu-Frimpong, Wenwen Deng, Huiyun Zhang, Jiangnan Yu, and Ximing Xu. "Self-microemulsifying Drug Delivery System for Improved Oral Delivery of Limonene: Preparation, Characterization, in vitro and in vivo Evaluation." AAPS PharmSciTech 20, no. 4 (2019): 153. (SCI, IF =1.6)

    [3] Mensah, Merlin LK, Gustav Komlaga, Arnold D. Forkuo, Caleb Kesse Firempong, Alexander K. Anning, and Rita A. Dickson. "Toxicity and Safety Implications of Herbal Medicines Used in Africa." Herbal Medicine (2019): 63.

    [4]  Yingshu Feng, Jinyi Wan, Baoding Chen, Yuan Zhu, Caleb Kesse Firempong, Chunlai Feng, Teruko Imai, Jiangnan Yu, Ximing Xu. “In vitro metabolic profiling of periplogenin in rat liver microsomes and its associated enzyme-kinetic evaluationCurrent Pharmaceutical Analysis. (2019). DOI: 10.2174/1573412915666190101101710(SCI, IF =0.859)



    [1] Zhen, Lijun, Qiuyu Wei, Qilong Wang, Huiyun Zhang, Michael Adu-Frimpong, Caleb Kesse Firempong, Ximing Xu, and Jiangnan Yu. "Preparation and in vitro/in vivo evaluation of 6-Gingerol TPGS/PEG-PCL polymeric micelles." Pharmaceutical Development and Technology. (2018): 1-30. (SCI, IF =0.60)

    [2] Adu?Frimpong, Michael, Caleb Kesse Firempong, Emmanuel Omari?Siaw, Qilong Wang, Yusif Mohammed Mukhtar, Wenwen Deng, Qingtong Yu, Ximing Xu, and Jiangnan Yu. "Preparation, optimization, and pharmacokinetic study of nanoliposomes loaded with triacylglycerol?bound punicic acid for increased antihepatotoxic activity." Drug development research (2018). (SCI, IF =0.60)

    [3] Wang, Qilong, Qiuxuan Yang, Xia Cao, Qiuyu Wei, Caleb K. Firempong, Min Guo, Feng Shi, Ximing Xu, Wenwen Deng, and Jiangnan Yu. "Enhanced oral bioavailability and anti-gout activity of [6]-shogaol-loaded solid lipid nanoparticles." International journal of pharmaceutics 550, no. 1-2 (2018): 24-34. (SCI, IF =3.862)

    [4] Feng, Yingshu, Yuan Zhu, Jinyi Wan, Xia Yang, Caleb Kesse Firempong, Jiangnan Yu, and Ximing Xu. "Enhanced oral bioavailability, reduced irritation and increased hypolipidemic activity of self-assembled capsaicin prodrug nanoparticles." Journal of Functional Foods 44 (2018): 137-145 (SCI, IF =3.144).



    [1] Wang Yuanwen, Shicheng Wang, Caleb Kesse Firempong, Huiyun Zhang, Miaomiao Wang, Ya Zhang, Yuan Zhu, Jiangnan Yu, and Ximing Xu. "Enhanced Solubility and Bioavailability of Naringenin via Liposomal Nanoformulation: Preparation and In Vitro and In Vivo Evaluations." AAPS PharmSciTech (2017): 1-9. (SCI, IF =1.6)



    [1] Omari-Siaw, Emmanuel, Qilong Wang, Congyong Sun, Zengquan Gu, Yuan Zhu, Xia Cao, Caleb Kesse Firempong, Rita Agyare, Ximing Xu, and Jiangnan Yu. "Tissue distribution and enhanced in vivo anti-hyperlipidemic-antioxidant effects of perillaldehyde-loaded liposomal nanoformulation against Poloxamer 407-induced hyperlipidemia." International Journal of Pharmaceutics. (2016). (SCI, IF =3.65)

    [2] Caleb Kesse Firempong, Kwabena Nsiah, Francis Agyemang Yeboah. Some clinical and haematological effect of G6PD deficiency among individuals with sickle cell disorders in Kumasi, Ghana. The Journal of Medical Research. (2016): 2 (3): 81-85

    [3] C. K. Firempong, L.A. Andoh., W.G. Akanwariwiak, P. Addo-Fordjour, P. Adjakofi. Phytochemical screening and antifungal activities of crude ethanol extracts of red-flowered silk cotton tree (Bombax buonopozense) and Calabash nutmeg (Monodora myristica) on Candida albicans. Journal of Microbiology and Antimicrobials. 2016 8 (4): 22-27.

    [4] Caleb Kesse Firempong, Hui Yun Zhang, Yan Wang, Jingjing Chen , Xia Cao,  Jie Zhou, Qiang Wang, Shan-Shan Tong, Jiangnan Yu and Ximing Xu. Segetoside I, a plant-derived bisdesmosidic saponin, induces apoptosis in human hepatoma cells in vitro and inhibits tumor growth in vivo. Pharmacological Research. 2016. DOI: 10.1016/j.phrs.2016.04.032 (SCI, IF =4.4 1) 

    [5] Huiyun Zhang, Caleb Kesse Firempong, Yuanwen Wang, Wenqian Xu, Miaomiao Wang, Xia-Cao, Yuan Zhu, Shanshan Tong, Jiangnan Yu and Ximing Xu. Enhanced in vitro antitumor activity and oral bioavailability of ergosterol-loaded poly(lactide-co-glycolide) nanoparticles. Acta Pharmacologica sinica. 2016. (SCI, IF =3.16)

    [6] Wang Yuanwen, Shicheng Wang, Caleb Kesse Firempong, Huiyun Zhang, Miaomiao Wang, Ya Zhang, Yuan Zhu, Jiangnan Yu, and Ximing Xu. "Enhanced Solubility and Bioavailability of Naringenin via Liposomal Nanoformulation: Preparation and In Vitro and In Vivo Evaluations." AAPS PharmSciTech (2016): 1-9. (SCI, IF =1.6)

    [7] Omari-Siaw Emmanuel, Yuan Zhu, Houyong Wang, Wei Peng, Caleb Kesse Firempong, Yuan Wen Wang, Xia Cao, Wenwen Deng, Jiangnan Yu, and Ximing Xu. "Hypolipidemic potential of perillaldehyde-loaded self-nanoemulsifying delivery system in high-fat diet induced hyperlipidemic mice: Formulation, in vitro and in vivo evaluation." European Journal of Pharmaceutical Sciences 85 (2016): 112-122. (SCI, IF =3.35)

    [8] Feng, Yingshu, Congyong Sun, Yangyang Yuan, Yuan Zhu, Jinyi Wan, Caleb Kesse Firempong, Emmanuel Omari-Siaw et al. "Enhanced oral bioavailability and in vivo antioxidant activity of chlorogenic acid via liposomal formulation." International Journal of Pharmaceutics 501, no. 1 (2016): 342-349. (SCI, IF =3.65)

    [9] Shi Feng, Yingying Zhao, Caleb Kesse Firempong, and Ximing Xu. "Preparation, characterization and pharmacokinetic studies of linalool-loaded nanostructured lipid carriers." Pharmaceutical Biology (2016): 1-9. (SCI, IF =1.24)



    [1] Caleb Kesse Firempong, Xia Cao, Shan-Shan Tong, Jiangnan Yu and Ximing Xu. Prospects of multitarget lipid-raft-coated silica beads: Remarkable on-line biomaterial for discovering multitarget antitumor lead compounds. RSC Advances. 2015 5: 49330 (SCI, IF=3.708)

    [2] Yingying Zhao, Chaonan Sun, Feng Shi, Caleb Kesse Firempong, Jiangnan Yu, Ximing Xu, Weiming Zhang. Preparation, characterization and pharmacokinetics study of capsaicin via hydroxypropyl-beta-cyclodextrin encapsulation. Pharmaceutical Biology. 2015 8:1-9. (SCI, IF=1.337)

    [3] Caleb Kesse Firempong, Hui-Yun Zhang , Jia-jia Zhang, Yan Wang, Xia Cao, Emmmanuel Omari-Siaw, Shan-Shan Tong, Jiangnan Yu and Ximing Xu. Lipid raft biomaterial as a mass screening affinity tool for rapid identification of potential antitumor Chinese herbal medicine. European Journal of Intergrative Medicine.2015 7: 365-371 (SCI, IF=0.88).

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