Prof. Kwabena Ofori-Kwakye

Professor

Dept: Pharmaceutics
1st Floor, Room C101, Tackie Building
Department of Pharmaceutics
Faculty of Pharmacy and Pharmaceutical Sciences
Kwame Nkrumah University of Science and Technology (KNUST)
Kumasi, Ghana
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Research Areas/Interests

Drug delivery; Formulation and drug design; Tableting and film coating technology; Quality evaluation of drugs; Development of herbal medicinal produc...~more

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Publications

    Research Articles

    1. Owusu FWA, Boakye-Gyasi ME, Agbenorhevi J, Bayor MT, Ofori-Kwakye K. (2021). Potential and comparative tablet disintegrant properties of pectin obtained from five okra genotypes in Ghana. Scientifica, volume 2021, Article ID 2902335, 11 pages. https://doi.org/10.1155/2021//2902335 
    2. Kumadoh D, Ofori Kwakye K, Kuntworbe N, Adi-Dako O, Appenahier JA. (2020). Determination of shelf life of four herbal medicinal products using high-performance liquid chromatography analyses of markers and the Systat Sigmaplot software. Journal of Applied Pharmaceutical Science 10(6), 072-080.
    3. Bediako A, Kuntworbe N, Johnson R, Bayor MT, Ofori-Kwakye K (2020). Formulation and evaluation of clarithromycin-loaded self-micro emulsified drug delivery system. International Journal of Pharmaceutical Sciences and Research 11(11), 5619-5632.
    4. Owusu, FWA, Boakye-Gyasi M, Mante PK, Ekuadzi E, Ofori-Kwakye K, Woode E. (2019). Formulation and evaluation of sustained release matrix tablets of capparis erythrocarpos roots extract to improve patient compliance in management of arthritis. Scientific African 6 e00172
    5. Adi-Dako O, Ofori-Kwakye K, Amponsah SK, Boamah I, Kuntworbe N, Oppong EE. (2018). Potential of cocoa pod husk pectin-based modified release capsules as a carrier for chronodelivery of hydrocortisone in Sprague-Dawley rats. Journal of Drug Delivery, volume 2018, Article ID 9825363, 8 pages. http://doi.org/10.1155/2018/9825363
    6. Adi-Dako O, Ofori-Kwakye K, Kukuia KKE, Asiedu-Larbi J, Nyarko A, Kumadoh D, Frimpong G. (2018). Subchronic toxicity studies of cocoa pod husk pectin intended as a pharmaceutical excipient in Sprague Dawley rats. Journal of Pharmacy & Pharmacognosy Research 6(4), 271-284.
    7. Adi-Dako O, Ofori-Kwakye K, Kukuia KKE, Asiedu-Larbi J, Nyarko AK, Kumadoh D, Osei-Asare C. (2018). Cocoa pod husk pectin intended as a pharmaceutical excipient has no adverse effects on haematological parameters in Sprague Dawley rats. Journal of Pharmaceutics, volume 2018, Article ID 1459849, 10 pages. http://doi.org/10.1155/2018/1459849
    8. Kwakye RA, Kuntworbe N, Ofori-Kwakye K, Osei YA (2018). Detection, quantification, and investigation of the red blood cell partitioning of cryptolepine hydrochloride. Journal of Pharmacy & Pharmacognosy Research 6(4), 260-270.
    9. Frimpong G, Ofori-Kwakye K, Kuntworbe N, Buabeng KO, Osei YA, Boakye-Gyasi ME, Adi-Dako O. (2018). Quality assessment of some essential children’s medicines sold in licensed outlets in Ashanti Region, Ghana. Journal of Tropical Medicine, volume 2018, Article ID 1494957, 14 pages. http://doi.org/10.1155/2018/1494957
    10. Kuntworbe N, Acquah FA, Johnson R, Ofori-Kwakye K. (2018). Comparison of the physicochemical properties and in vivo bioavailability of generic and innovator artemether-lumefantrin tablets in Kumasi, Ghana. Journal of Pharmacy & Pharmacognosy Research 6(3), 167-178.
    11.  Adi-Dako O, Ofori-Kwakye K, Boakye-Gyasi ME, Oppong Bekoe S, Okyem S. (2017). In vitro evaluation of cocoa pod husk pectin as a carrier for chronodelivery of hydrocortisone intended for adrenal insufficiency. Journal of Drug Delivery, volume 2017, Article ID 8284025, 10 pages. http://doi.org/10.1155/2017/8284025
    12. Adi-Dako O, Oppong Bekoe S, Ofori-Kwakye K, Appiah E, Peprah P. (2017). Novel HPLC analysis of hydrocortisone in conventional and controlled-release pharmaceutical preparations. Journal of Pharmaceutics, volume 2017, Article ID 9495732, 8 pages. http://doi.org/10.1155/2017/9495732
    13. Adjei FK, Osei YA, Kuntworbe N, Ofori-Kwakye K. (2017). Evaluation of the disintegrant properties of native starches of five new cassava varieties in paracetamol tablet formulations.  Journal of Pharmaceutics, volume 2017, Article ID 2326912, 9 pages. https://doi.org/10.1155/2017/2326912       
    14. Mensah A, Kuntworbe N, Johnson R, Ofori-Kwakye K. (2017). Qualitative and quantitative assessment of cryptolepis-based herbal formulations within the Kumasi metropolis in Ghana. Journal of Innovations in Pharmaceutical and Biological Sciences, 4(1), 58-65.       
    15. Bonsu MA, Ofori-Kwakye K, Kipo SL, Boakye-Gyasi ME, Fosu M-A. (2016). Development of oral dissolvable films of diclofenac sodium for osteoarthritis using Albizia and Kahaya gums as hydrophilic film formers. Journal of Drug Delivery, volume 2016, Article ID 6459280, 11 pages. http://dx.doi.org/10.1155/2016/6459280 
    16. Frimpong G, Ofori-Kwakye K. (2016). Access to essential medicines in Ghana: A survey of availability of children’s medicines in medicine outlets in the Ashanti Region. Journal of Pharmaceutical Science 6(10), 020-028. 
    17. Fosu MA, Ofori-Kwakye K, Kuntworbe N, Bonsu MA. (2016). Investigation of blends of cashew and xanthan gums as a potential carrier for colonic delivery of ibuprofen. International Journal of PharmTech Research 9(7), 369-380.
    18. Adi-Dako O, Ofori-Kwakye K, Frimpong-Manso S, Boakye-Gyasi M, Sasu C, Pobee M. (2016). Physicochemical and antimicrobial properties of cocoa pod husk pectin intended as a versatile pharmaceutical excipient and nutraceutical. Journal of Pharmaceutics, volume 2016, Article ID 7608693, 12 pages. http://dx.doi.org/10.1155/2016/7608693
    19. Ofori-Kwakye K, Mfoafo KA, Kipo SL, Kuntworbe N, Boakye-Gyasi ME. (2016). Development and evaluation of extended release matrix tablets of two model drugs of different water solubilities by direct compression. Saudi Pharmaceutical Journal, 24, 82 – 91. http://dx.doi.org/10.1016/j.jsps.2015.03.005
    20. Sougi A, Ofori-Kwakye K, Kuntworbe N, Kipo SL, Boakye-Gyasi ME. (2015). Evaluation of the physicochemical properties of metformin hydrochloride tablet brands marketed in five cities in Ghana. British Journal of Pharmaceutical Research, 9 (1), 1 – 14. DOI : 10.9734/BJPR/2016/21862
    21. Kipo SL, Osei YG, Kuntworbe N, Bayor MT, Ofori-Kwakye K, Boakye-Gyasi ME (2015). Development and in vitro evaluation of oral gels and vaginal pessaries from crude extracts of four Ghanaian medicinal plants intended for the treatment of candidiasis. World Journal of Pharmaceutical Research. World Journal of Pharmaceutical Research, 4 (8), 174 – 194. 
    22. Kipo SL, Osei-Asare C, Ofori-Kwakye K, Buabeng KO, Anto BP (2015). Physician and patient preferences for sustained release antihypertensive preparations in the Kumasi metropolis, Ghana. West African Journal of Pharmacy, 26 (1), 1-10. 
    23. Osei-Asare C, Kipo SL, Ofori-Kwakye K, Boakye-Gyasi EM (2015). Comparative in vitro dissolution of commercially available sustained release nifedipine tablet brands in the Kumasi Metropolis, Ghana. Journal of Applied Pharmaceutical Science, 5 (08), 054-060. DOI: 10.7324/JAPS.2015.50809 
    24. Kumadoh D, Adotey J, Ofori-Kwakye K, Kipo SL, Prah T, Patterson S. (2015). Development of oral capsules from enterica herbal decoction – a traditional remedy for typhoid fever in Ghana. Journal of Applied Pharmaceutical Science, 5(04), 083 – 088. DOI: 10.7324/JAPS.2015.50414 
    25. Kipo SL, Oppong EE, Ofori-Kwakye K.  (2014). Physicochemical evaluation and tablet formulation properties of shea tree gum. Asian Journal of Pharmaceutical and Clinical Research 7 (5), 121 – 127.
    26. Frimpong G, Adotey J, Ofori-Kwakye K, Kipo SL, Dwomo-Fokuo Y. (2014). Potential of aqueous extract of Hibiscus sabdariffa calyces as coloring agent in three pediatric oral pharmaceutical formulations. Journal of Applied Pharmaceutical Science, 4(12). 001 -007. DOI: 10.7324/JAPS.2014.41201 
    27. Kumadoh D, Adotey J, Ofori-Kwakye K, Kipo SL, Prah T, Patterson S. (2014). Formulation of oral capsules from asena herbal decoction used traditionally in Ghana for the treatment of arthritis. World Journal of Pharmacy and Pharmaceutical Sciences, 3(7), 1824 – 1833.
    28. Ofori-Kwakye K, Ayensu I, Akyinah B, Kipo SL, Boakye-Gyasi ML. (2014). Adulteration of Ghanaian topical herbal preparations with dexamethasone. World Journal of Pharmacy and Pharmaceutical Sciences, 3(6), 134 – 141.
    29. Ofori-Kwakye K, Obese E, Boakye-Gyasi, ME. (2013). Formulation and in-vitro evaluation of sustained release diclofenac sodium matrix tablets using blends of cashew gum, xanthan gum and hydroxypropylmethylcellulose as hydrophilic drug release modifiers. Indian Journal of Novel Drug Delivery 5(4), 187 – 197. 
    30. Ofori-Kwakye K, Amekyeh H, El-Duah M, Kipo SL. (2012). Mechanical and tablet coating properties of cashew tree (Anacardium occidentale L) gum-based films. Asian Journal of Pharmaceutical and Clinical Research 5 (4), 62 – 68.
    31. El-Duah M, Ofori-Kwakye K. (2012). Substandard artemisinin-based antimalarial medicines in licensed retail pharmaceutical outlets in Ghana. Journal of Vector Borne Diseases 49, 131 – 139.
    32. Bediako A, Adotey J, Ofori-Kwakye K. (2011). Pharmacokinetics of amodiaquine after a single oral dose in Ghanaian children with uncomplicated malaria. Journal of Pharmaceutical Sciences and Research 3 (8), 1420 – 1426.
    33. Asantewaa Y, Ofori-Kwakye K, Kipo SL, Boamah VE, Johnson R. (2011). Investigation of the emulsifying and suspending potential of cashew tree gum in pharmaceutical formulations. International Journal of Pharmacy and Pharmaceutical Sciences 3 (4), 215 - 219.
    34. Kobierski S, Ofori-Kwakye K, Müller RH, Keck CM. (2011). Resveratrol nanosuspensions: interaction of preservatives with nanocrystal production. Die Pharmazie 66, 942 – 947. DOI: 10.1691/ph.2011.1038
    35. Ofori-kwakye K, Kwapong AA, Bayor MT. (2011). Wound healing potential of methanol extract of Spathodea campanulata stem bark formulated into a topical preparation. African Journal of Traditional, Complementary and Alternative Medicine 8 (3), 218 – 223.
    36. Boamah VE, Gbedema SY, Adu F, Ofori-Kwakye K. (2011). Microbial quality of household water sources and incidence of diarrhoea in three peri-urban communities in Kumasi, Ghana. Journal of Pharmaceutical Sciences and Research 3 (3), 1087 – 1092. 
    37. Ofori-Kwakye K, Asantewaa Y, Kipo SL. (2010). Physicochemical and binding properties of cashew tree gum in metronidazole tablet formulations. International Journal of Pharmacy and Pharmaceutical Sciences 2 (4), 105 - 109.
    38. Ofori-Kwakye K, Osei-Yeboah F, Kipo SL. (2010). Formulation and quality evaluation of two conventional release tablet formulations. International Journal of Pharmaceutical Sciences Review and Research 4 (1), 94 – 99.
    39. Bayor MT, Kipo SL, Ofori-Kwakye K. (2010). The accuracy and quality of household spoons and enclosed dosing devices used in the administration of oral liquid medications in Ghana. International Journal of Pharmacy and Pharmaceutical Sciences 2 (Suppl.1), 150 – 153. 
    40. Ofori-Kwakye K, Adom ENN, Kipo SL. (2009). Preparation and in vitro characteristics of tablet cores coated with albizia, albizia/khaya and albizia/HPMC films. International Journal of Applied Pharmaceutics 1 (1), 22 - 29.
    41. Kobierski S, Ofori-Kwakye K, Müller RH, Keck CM. (2009). Resveratrol nanosuspensions for dermal application – production, characterization and physical stability. Die Pharmazie 64 (11), 741 - 747. DOI: 10.1691/ph.2009.9097 
    42. Ofori-Kwakye K, Kwapong AA, Adu F. (2009). Antimicrobial activity of extracts and topical products of the stem bark of Spathodea campanulata for wound healing. African Journal of Traditional, Complementary and Alternative Medicine 6 (2), 168 – 174. 
    43. Ofori-Kwakye K, Asantewaa Y, Gaye O. (2008). Quality of artesunate tablets sold in pharmacies in Kumasi, Ghana. Tropical Journal of Pharmaceutical Research 7 (4), 1179 – 1184.
    44. Ofori-Kwakye K, Adom ENN. (2007). Mechanical properties of khaya and albizai films intended for pharmaceutical coating. Journal of Ghana Science Association 9 (2), 43 – 53. DOI: 10.4314/jgsa.v9i2.18013
    45. Kuntworbe N, Adotey J, Ofori-Kwakye K, Kipo SL. (2006). Formulation and evaluation of a combined chloroquine phosphate and chlorpheniramine maleate product. Journal of Science and Technology (Ghana) 26 (3), 32 – 39. DOI: 10.4314/just.v26i3.33002 
    46. Dwomo-Fokuo Y, Owusu-Antwi R, Ofori-Kwakye K. (2006). Locally derived starches as potential alternative tablet disintegrant and binder sources. Ghana Pharmaceutical Journal 32 (1), 43 – 48. 
    47. Ofori-Kwakye K, Fell JT, Kipo SL. (2006). Effects of pH of medium and molecular weight on polyelectrolyte complex formation between pectin and chitosan. Journal of Science and Technology (Ghana), 26 (2), 66 – 73. DOI: 10.4314/just.v26i2.32990 
    48. Ofori-Kwakye K, Martin, GP. (2005). Viscoelastic characterization of alginate gels intended for wound healing. Journal of Science and Technology (Ghana) 25 (2), 46 – 52. DOI: 10.4314/just.v25i2.32946 
    49. Ofori-Kwakye K, Fell JT. (2005). Effect of mixed film coating on pharmacokinetics of paracetamol tablets. Journal of Science and Technology (Ghana) 25 (1), 25 – 32. DOI: 10.4314/just.v25i1.32929
    50. Ofori-Kwakye K, Fell JT, Sharma HL, Smith A-M. (2004). Gamma scintigraphic evaluation of film-coated tablets intended for colonic or biphasic release. International Journal of Pharmaceutics 270, 307 – 313. DOI:10.1016/j.ijpharm.2003.11.009
    51. Ofori-Kwakye K, Fell JT. (2003). Leaching of pectin from mixed films containing pectin, chitosan and HPMC intended for biphasic drug delivery. International Journal of Pharmaceutics 250, 251 – 257. DOI:10.1016/S0378-5173(02)00546-X
    52. Ofori-Kwakye K, Fell JT. (2003). Biphasic drug release from film-coated tablets. International Journal of Pharmaceutics 250, 431 – 440. DOI:10.1016/S0378-5173(02)00578-1
    53. Ofori-Kwakye K, Fell JT. (2001). Biphasic drug release: the permeability of films containing pectin, chitosan and HPMC. International Journal of Pharmaceutics 226, 139 – 145. DOI:10.1016/S0378-5173(01)00802-X
    54. Ofori-Kwakye K, Fell JT. (2000). Permeability of pectin/chitosan/HPMC films intended for colonic or bimodal drug delivery. Journal of Pharmacy and Pharmacology 52, (Supplement): 172.    

      Review Articles

     

    1. Bediako A, Kuntworbe N, Johnson R, Baryor MT, Ofori-Kwakye K. (2019). Self-micro emulsifying drug delivery: a potential solution to the challenges of oral delivery of poorly water-soluble drugs. International Journal of Pharmaceutical Sciences, Reviews and Research 58(1), 34-44.
    2. Kumadoh D, Ofori-Kwakye K. (2017). Dosage forms of herbal medicinal products and their stability considerations – an overview. Journal of Critical Reviews 4(4), 1-8.
    3. Ofori-Kwakye K, Kipo,SL, Fell JT. (2006). Colonic drug delivery and absorption. Ghana Pharmaceutical Journal 31 (1), 49 – 64.

       

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