Dr. Michael Frimpong

Lecturer


Dept: Molecular Medicine
School of Medicine and Dentistry
Department of Molecular Medicine

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Research Areas/Interests

Emerging Infectious diseases Immunopathogenesis of infectious diseases Development of diagnostic tools for resource-limited settings Computationa...~more

My full CV

Publications

    1: Amoako YA, Ackam N, Omuojine JP, Oppong MN, Owusu-Ansah AG, Boateng H, AbassMK, Amofa G, Ofori E, Okyere PB, Frimpong M, Bailey F, Molyneux DH, Phillips RO. Mental health and quality of life burden in Buruli ulcer disease patients in Ghana. Infect Dis Poverty. 2021 Aug 17;10(1):109. doi:10.1186/s40249-021-00891-8. PMID: 34404483; PMCID: PMC8367773.

    2: Amoako YA, Ackam N, Omuojine JP, Oppong MN, Owusu-Ansah AG, Abass MK, Amofa G, Ofori E, Frimpong M, Bailey F, Molyneux DH, Phillips RO. Caregiver burden in Buruli ulcer disease: Evidence from Ghana. PLoS Negl Trop Dis. 2021 Jun 1;15(6):e0009454. doi: 10.1371/journal.pntd.0009454. PMID: 34061828; PMCID: PMC8195390.

    3: Frimpong M, Amoako YA, Anim KB, Ahor HS, Yeboah R, Arthur J, Dakorah JS, Gborgblovor D, Akrofi S, Sekyi-Djan P, Owusu M, Sylverken AA, Binger T, Phillips RO. Diagnostics for COVID-19: A case for field-deployable, rapid molecular tests for community surveillance. Ghana Med J. 2020 Dec;54(4 Suppl):71-76. doi:10.4314/gmj.v54i4s.11. PMID: 33976444; PMCID: PMC8087371.

    4: Owusu M, Sylverken AA, El-Duah P, Ayisi-Boateng NK, Yeboah R, Adu E, Asamoah J, Frimpong M, Senyo J, Acheampong G, Mutocheluh M, Amuasi J, Owusu-Dabo E, Adu-Sarkodie Y, Phillips RO. Low risk of SARS-CoV-2 in blood transfusion. PLoS One. 2021 Apr 13;16(4):e0249069. doi: 10.1371/journal.pone.0249069. PMID: 33848293;
    PMCID: PMC8043372.

    5: Amoako YA, Loglo AD, Frimpong M, Agbavor B, Abass MK, Amofa G, Ofori E, Ampadu E, Asiedu K, Stienstra Y, Wansbrough-Jones M, van der Werf T, Phillips RO. Co-infection of HIV in patients with Buruli ulcer disease in Central Ghana. BMC Infect Dis. 2021 Apr 8;21(1):331. doi: 10.1186/s12879-021-06009-7. PMID: 33832460; PMCID: PMC8028811.

    6: Sylverken AA, El-Duah P, Owusu M, Schneider J, Yeboah R, Ayisi-Boateng NK, Gorman R, Adu E, Kwarteng A, Frimpong M, Binger T, Aryeetey S, Asamoah JA, Amoako YA, Amuasi JH, Beheim-Schwarzbach J, Owusu-Dabo E, Adu-Sarkodie Y, Obiri-Danso K, Corman VM, Drosten C, Phillips R. Transmission of SARS-CoV-2 in northern Ghana: insights from whole-genome sequencing. Arch Virol. 2021 May;166(5):1385-1393. doi: 10.1007/s00705-021-04986-3. Epub 2021 Mar 15. PMID:33723631; PMCID: PMC7959303.

    7: Simpson H, Tabah EN, Phillips RO, Frimpong M, Maman I, Ampadu E, Timothy J, Saunderson P, Pullan RL, Cano J. Mapping suitability for Buruli ulcer at fine spatial scales across Africa: A modelling study. PLoS Negl Trop Dis. 2021 Mar
    3;15(3):e0009157. doi: 10.1371/journal.pntd.0009157. PMID: 33657104; PMCID: PMC7959670.

    8: Frimpong M, Kyei-Tuffuor L, Fondjo LA, Ahor HS, Adjei-Kusi P, Maiga-Ascofare O, Phillips RO. Evaluation of a real-time recombinase polymerase amplification assay for rapid detection of Schistosoma haematobium infection in resource-limited setting. Acta Trop. 2021 Apr;216:105847. doi:10.1016/j.actatropica.2021.105847. Epub 2021 Jan 23. PMID: 33497617.

    9: El Wahed AA, Patel P, Maier M, Pietsch C, Rüster D, Böhlken-Fascher S, Kissenkötter J, Behrmann O, Frimpong M, Diagne MM, Faye M, Dia N, Shalaby MA, Amer H, Elgamal M, Zaki A, Ismail G, Kaiser M, Corman VM, Niedrig M, Landt O, Faye O, Sall AA, Hufert FT, Truyen U, Liebert UG, Weidmann M. Suitcase Lab for Rapid Detection of SARS-CoV-2 Based on Recombinase Polymerase Amplification Assay. Anal Chem. 2021 Feb 2;93(4):2627-2634. doi:10.1021/acs.analchem.0c04779. Epub 2021 Jan 20. PMID: 33471510; PMCID: PMC7839158.

    10: Amoako YA, Phillips RO, Arthur J, Abugri MA, Akowuah E, Amoako KO, Marfo BA, Frimpong M, van der Werf T, Ravensbergen SJ, Stienstra Y. A scabies outbreak in the North East Region of Ghana: The necessity for prompt intervention. PLoS Negl Trop Dis. 2020 Dec 22;14(12):e0008902. doi: 10.1371/journal.pntd.0008902. PMID:
    33351803; PMCID: PMC7787682.

    11: Frimpong M, Simpson SV, Ahor HS, Agbanyo A, Gyabaah S, Agbavor B, Amanor IB, Addo KK, Böhlken-Fascher S, Kissenkötter J, Wahed AAE, Phillips RO. Multiplex Recombinase Polymerase Amplification Assay for Simultaneous Detection of Treponema pallidum and Haemophilus ducreyi in Yaws-Like Lesions. Trop Med Infect Dis. 2020 Oct 6;5(4):157. doi: 10.3390/tropicalmed5040157. PMID: 33036234; PMCID: PMC7709673.

    12: Collinson S, Frimpong VNB, Agbavor B, Montgomery B, Oppong M, Frimpong M, Amoako YA, Marks M, Phillips RO. Barriers to Buruli ulcer treatment completion in the Ashanti and Central Regions, Ghana. PLoS Negl Trop Dis. 2020 May
    26;14(5):e0008369. doi: 10.1371/journal.pntd.0008369. PMID: 32453800; PMCID: PMC7274448.

    13: Asare R, Opoku-Okrah C, Danquah KO, Opare-Sem O, Addai-Mensah O, Gyamfi D, Amponsah FA, Afriyie EY, Duneeh RV, Ofosu DN, Frimpong M. Assessment of platelet indices and platelet activation markers in children with Plasmodium falciparum malaria. Malar J. 2020 Apr 8;19(1):143. doi: 10.1186/s12936-020-03218-4. PMID:
    32268918; PMCID: PMC7140500.

    14: Phillips RO, Robert J, Abass KM, Thompson W, Sarfo FS, Wilson T, Sarpong G, Gateau T, Chauty A, Omollo R, Ochieng Otieno M, Egondi TW, Ampadu EO, Agossadou D, Marion E, Ganlonon L, Wansbrough-Jones M, Grosset J, Macdonald JM, Treadwell T, Saunderson P, Paintsil A, Lehman L, Frimpong M, Sarpong NF, Saizonou R, Tiendrebeogo A, Ohene SA, Stienstra Y, Asiedu KB, van der Werf TS; study team. Rifampicin and clarithromycin (extended release) versus rifampicin and streptomycin for limited Buruli ulcer lesions: a randomised, open-label, non-inferiority phase 3 trial. Lancet. 2020 Apr 18;395(10232):1259-1267. doi: 10.1016/S0140-6736(20)30047-7. Epub 2020 Mar 12. PMID: 32171422; PMCID:PMC7181188.

    15: Frimpong M, Ahor HS, Sakyi SA, Agbavor B, Akowuah E, Phillips RO. Rapid Extraction Method of Mycobacterium ulcerans DNA from Clinical Samples of Suspected Buruli Ulcer Patients. Diagnostics (Basel). 2019 Nov 26;9(4):204. doi:10.3390/diagnostics9040204. PMID: 31779247; PMCID: PMC6963521.

    16: Wadagni AC, Steinhorst J, Barogui YT, Catraye PM, Gnimavo R, Abass KM, Amofa G, Frimpong M, Sarpong FN, van der Werf TS, Phillips R, Sopoh GE, Johnson CR, Stienstra Y. Buruli ulcer treatment: Rate of surgical intervention differs highly between treatment centers in West Africa. PLoS Negl Trop Dis. 2019 Oct 28;13(10):e0007866. doi: 10.1371/journal.pntd.0007866. PMID: 31658295; PMCID: PMC6855495.

    17: Frimpong M, Agbavor B, Duah MS, Loglo A, Sarpong FN, Boakye-Appiah J, Abass KM, Dongyele M, Amofa G, Tuah W, Frempong M, Amoako YA, Wansbrough-Jones M, Phillips RO. Paradoxical reactions in Buruli ulcer after initiation of
    antibiotic therapy: Relationship to bacterial load. PLoS Negl Trop Dis. 2019 Aug 26;13(8):e0007689. doi: 10.1371/journal.pntd.0007689. PMID: 31449522; PMCID:PMC6709892.

    18: Asare R, Opoku-Okrah C, Danquah KO, Opare-Sem O, Addai-Mensah O, Gyamfi D, Amponsah FA, Afriyie EY, Duneeh RV, Ofosu DN, Frimpong M. Expression of platelet parameters and platelet membrane glycoproteins in childhood Burkitt lymphoma. Leuk Res. 2019 Sep;84:106189. doi: 10.1016/j.leukres.2019.106189. Epub 2019 Jul
    12. PMID: 31326577.

    19: Amoako YA, Frimpong M, Awuah DO, Plange-Rhule G, Boakye-Yiadom E, Agbavor B, Sarpong F, Ahor H, Adu E, Danso KG, Abass MK, Asiedu K, Wansbrough-Jones M, Phillips RO. Providing insight into the incubation period of Mycobacterium ulcerans disease: two case reports. J Med Case Rep. 2019 Jul 18;13(1):218. doi:
    10.1186/s13256-019-2144-2. PMID: 31315637; PMCID: PMC6637553.

    20: Simpson H, Deribe K, Tabah EN, Peters A, Maman I, Frimpong M, Ampadu E, Phillips R, Saunderson P, Pullan RL, Cano J. Mapping the global distribution of Buruli ulcer: a systematic review with evidence consensus. Lancet Glob Health. 2019 Jul;7(7):e912-e922. doi: 10.1016/S2214-109X(19)30171-8. PMID: 31200890; PMCID: PMC6614043.

    21: Frimpong M, Ahor HS, Wahed AAE, Agbavor B, Sarpong FN, Laing K, Wansbrough-Jones M, Phillips RO. Rapid detection of Mycobacterium ulcerans with isothermal recombinase polymerase amplification assay. PLoS Negl Trop Dis. 2019 Feb 1;13(2):e0007155. doi: 10.1371/journal.pntd.0007155. PMID: 30707706; PMCID: PMC6373974.

    22: Loglo AD, Frimpong M, Sarpong Duah M, Sarfo F, Sarpong FN, Agbavor B, Boakye-Appiah JK, Abass KM, Dongyele M, Frempong M, Pidot S, Wansbrough-Jones M, Stinear TP, Roupie V, Huygen K, Phillips RO. IFN-γ and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with Mycobacterium ulcerans infection. PeerJ. 2018 Jul 31;6:e5294. doi:10.7717/peerj.5294. PMID: 30090691; PMCID: PMC6078848.

    23: Dekker D, Krumkamp R, Eibach D, Sarpong N, Boahen KG, Frimpong M, Fechtner E, Poppert S, Hagen RM, Schwarz NG, Adu-Sarkodie Y, Owusu-Dabo E, Im J, Marks F, Frickmann H, May J. Characterization of Salmonella enterica from invasive bloodstream infections and water sources in rural Ghana. BMC Infect Dis. 2018 Jan 19;18(1):47. doi: 10.1186/s12879-018-2957-4. PMID: 29351771; PMCID: PMC5775569.

    24: Sarpong-Duah M, Frimpong M, Beissner M, Saar M, Laing K, Sarpong F, Loglo AD, Abass KM, Frempong M, Sarfo FS, Bretzel G, Wansbrough-Jones M, Phillips RO. Clearance of viable Mycobacterium ulcerans from Buruli ulcer lesions during antibiotic treatment as determined by combined 16S rRNA reverse transcriptase/IS 2404 qPCR assay. PLoS Negl Trop Dis. 2017 Jul 3;11(7):e0005695. doi:10.1371/journal.pntd.0005695. PMID: 28671942; PMCID: PMC5510892.

    25: Boakye-Appiah JK, Steinmetz AR, Pupulampu P, Ofori-Yirenkyi S, Tetteh I, Frimpong M, Oppong P, Opare-Sem O, Norman BR, Stienstra Y, van der Werf TS, Wansbrough-Jones M, Bonsu F, Obeng-Baah J, Phillips RO. High prevalence of multidrug-resistant tuberculosis among patients with rifampicin resistance using GeneXpert Mycobacterium tuberculosis/rifampicin in Ghana. Int J Mycobacteriol. 2016 Jun;5(2):226-30. doi: 10.1016/j.ijmyco.2016.02.004. Epub 2016 Mar 8. PMID:27242237.

    26: Niang F, Sarfo FS, Frimpong M, Guenin-Macé L, Wansbrough-Jones M, Stinear T, Phillips RO, Demangel C. Metabolomic profiles delineate mycolactone signature in Buruli ulcer disease. Sci Rep. 2015 Dec 4;5:17693. doi: 10.1038/srep17693. PMID: 26634444; PMCID: PMC4669498.

    27: Wadagni A, Frimpong M, Phanzu DM, Ablordey A, Kacou E, Gbedevi M, Marion E, Xing Y, Babu VS, Phillips RO, Wansbrough-Jones M, Kishi Y, Asiedu K. Simple, Rapid Mycobacterium ulcerans Disease Diagnosis from Clinical Samples by Fluorescence of Mycolactone on Thin Layer Chromatography. PLoS Negl Trop Dis. 2015 Nov 19;9(11):e0004247. doi: 10.1371/journal.pntd.0004247. PMID: 26583925; PMCID: PMC4652903.

    28: Beissner M, Phillips RO, Battke F, Bauer M, Badziklou K, Sarfo FS, Maman I, Rhomberg A, Piten E, Frimpong M, Huber KL, Symank D, Jansson M, Wiedemann FX, Banla Kere A, Herbinger KH, Löscher T, Bretzel G. Loop-Mediated Isothermal Amplification for Laboratory Confirmation of Buruli Ulcer Disease-Towards a Point-of-Care Test. PLoS Negl Trop Dis. 2015 Nov 13;9(11):e0004219. doi:10.1371/journal.pntd.0004219. PMID: 26566026; PMCID: PMC4643924.

    29: Dekker DM, Krumkamp R, Sarpong N, Frickmann H, Boahen KG, Frimpong M, Asare R, Larbi R, Hagen RM, Poppert S, Rabsch W, Marks F, Adu-Sarkodie Y, May J. Drinking water from dug wells in rural ghana--salmonella contamination, environmental factors, and genotypes. Int J Environ Res Public Health. 2015 Mar 27;12(4):3535-46. doi: 10.3390/ijerph120403535. PMID: 25826395; PMCID: PMC4410201.

    30: Phillips RO, Phanzu DM, Beissner M, Badziklou K, Luzolo EK, Sarfo FS, Halatoko WA, Amoako Y, Frimpong M, Kabiru AM, Piten E, Maman I, Bidjada B, Koba A, Awoussi KS, Kobara B, Nitschke J, Wiedemann FX, Kere AB, Adjei O, Löscher T, Fleischer B, Bretzel G, Herbinger KH. Effectiveness of routine BCG vaccination on buruli ulcer disease: a case-control study in the Democratic Republic of Congo, Ghana and Togo. PLoS Negl Trop Dis. 2015 Jan 8;9(1):e3457. doi:10.1371/journal.pntd.0003457. PMID: 25569674; PMCID: PMC4287572.

    31: Phillips RO, Sarfo FS, Abass MK, Frimpong M, Ampadu E, Forson M, Amoako YA, Thompson W, Asiedu K, Wansbrough-Jones M. Reply to "compliance with antimicrobial therapy for buruli ulcer". Antimicrob Agents Chemother. 2014 Oct;58(10):6341. doi: 10.1128/AAC.03874-14. PMID: 25225343; PMCID: PMC4187934.

    32: Sarfo FS, Thompson W, Phillips RO, Paintsil A, Abass MK, Frimpong M, Abotsi J, Asiedu K, Wansbrough-Jones MH. A severe case of Buruli ulcer disease with pleural effusions. PLoS Negl Trop Dis. 2014 Jun 19;8(6):e2868. doi:
    10.1371/journal.pntd.0002868. PMID: 24945409; PMCID: PMC4063708.

    33: Phillips RO, Frimpong M, Sarfo FS, Kretschmer B, Beissner M, Debrah A, Ampem-Amoako Y, Abass KM, Thompson W, Duah MS, Abotsi J, Adjei O, Fleischer B, Bretzel G, Wansbrough-Jones M, Jacobsen M. Infection with Mansonella perstans Nematodes in Buruli Ulcer Patients, Ghana. Emerg Infect Dis. 2014 Jun;20(6):1000-3. doi: 10.3201/eid2006.131501. PMID: 24857346; PMCID: PMC4036786.

    34: Phillips RO, Sarfo FS, Landier J, Oldenburg R, Frimpong M, Wansbrough-Jones M, Abass K, Thompson W, Forson M, Fontanet A, Niang F, Demangel C. Combined inflammatory and metabolic defects reflected by reduced serum protein levels in patients with Buruli ulcer disease. PLoS Negl Trop Dis. 2014 Apr 10;8(4):e2786. doi:10.1371/journal.pntd.0002786. PMID: 24722524; PMCID: PMC3983110.


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