Dr. Philip Kwadzo Selorm Segbefia

Senior Technician


Dept: Molecular Medicine
Department of Molecular Medicine,
KNUST School of Medicine and Dentistry

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Research Areas/Interests

immune system modulation, vaccine development, and the impact of chronic infections on immune competence...~more


Profile

Selorm is an immunologist with a strong foundation in biomedical research and extensive experience in both academic and clinical laboratory settings. He earned his PhD in Immunology (2024) from Kwame Nkrumah University of Science and Technology (KNUST), Ghana. His doctoral research focused on assessing immune responses to Plasmodium falciparum in individuals with and without chronic hepatitis B virus (HBV) infection in Accra, Ghana. Utilizing advanced immunological techniques, including cytokine profiling via a 13-plex Luminex assay, his study provided critical insights into the potential impacts of chronic HBV on malaria vaccine efficacy in HBV-endemic regions. This work led to the publication of a review and two peer-reviewed research articles. 

Selorm also holds an MSc in Molecular Medicine from the University of Reading, UK (2019), where he honed his expertise in molecular biology techniques such as CRISPR/Cas9 gene editing, RNA extraction, and plasmid construction. His research project explored the role of *Phospholipase C gamma 2* (PLC-γ2) mutations in ibrutinib resistance in chronic lymphocytic leukemia, highlighting potential therapeutic targets within the B-cell receptor signaling pathway. 

His academic journey began with a BSc in Medical Laboratory Technology (First Class Honours) from the Garden City University College, an institution affiliated to the KNUST (2017) and a Diploma in Medical Laboratory Technology (Distinction) from the College of Health and Well Being, Ghana (2010). Over the years, he has developed expertise in haematology, clinical chemistry, medical microbiology, and molecular biology, culminating in a research dissertation on the association between haemoglobin variants, blood group systems, and malaria parasitaemia in children. 

Professionally, Selorm has contributed significantly to research and teaching. As a Graduate Research Officer with the HEPMAL Project at the Noguchi Memorial Institute for Medical Research, Ghana, he conducted studies on immune system modulation and the effects of chronic HBV on malaria vaccine efficacy. Additionally, as a Senior Technician at KNUST, he has guided undergraduate students through practical biochemistry lessons and supported their research projects. Earlier in his career, he spearheaded the establishment of the Laboratory at the Essam Government Hospital, where he was part of the team who commenced the operations of this new hospital.  

Selorm's research interests include immune system modulation, vaccine development, and the impact of chronic infections on immune competence. His goal is to unravel the complexities of host-pathogen interactions and contribute to the design of effective therapeutic and preventive strategies for infectious and chronic diseases.  


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