Prof. Robert Amadu Ngala

Professor

Dept: Molecular Medicine
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Research Areas/Interests

1. Diabetes and Obesity 2. Metabolic Syndrom 3. Discovery and development of Antidiabetic Drugs from Tropical Plants 4. Nutritional an Medicinal Effec...~more

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Publications

             

            BOOK

            published: Dietary vegetable oil consumption on glucose levels in diabetic mice;
            Robert A Ngala & Isaac Ampong.
            Lambert Academic Publishiong- Germany: ISBN:978-3-659-92011-0
            Copyright 2016 OmniScriptum Gmbh&Co.KG

             Some Recent Publications

    1. Benjamin Kingsley Harley, Rita Akosua Dickson, Isaac Kingsley Amponsah,Robert A Ngala,  Dorice Berkoh,, Theophilus Christian Fleischer: Antidiabetic effect of Chrysophyllum albidumis mediated by enzyme inhibition and enhancement of glucose uptake via3T3-L1 adipocytes and C2C12 myotubes Asian Pacific Journal of Tropical Biomedicine 2020; 10(9): 387-396
    1. Ahmed Tijani Bawah Robert Amadu Ngala, Mohammed Mustapha Seini, Francis Abeku Ussher, Huseini Alidu, Joshua Dokurugu Kwame Wumbee, Francis Agyeman Yeboah (2019). Gestational diabetes mellitusand obstetric outcomes in a Ghanaian community Int J Reprod Contracept Obstet Gynecol. 8(1):204-20
    1. Robert Amadu Ngala Martin Akilla and Paul Nsiah (2018). The effect of plasma chromium on lipid profile, glucose metabolism and cardiovascular risk in type 2 diabetes mellitus. A case control study. PLoSONE 13(7):e0197977.https//doi.org/10.1371/journal.pone.01979774. 
    2. Ngala RA, Fondjo LA, Gmagna P, Ghartey FN, Awe MA (2017). Placental peptides metabolism and Maternal factors as predictors of risk of gestational diabetes in pregnant women. A case control study. PLoSONE12 (7):e0181613.https://doi.org/10.1371/journal.pone.0181613
    1. Yeboah FA1, Ngala RA1, Bawah AT2, Asare-Anane H3, Alidu H2, Hamid AM2, Wumbee JDK4.Adiposity and hyperleptinemia during the first trimester among pregnant women with preeclampsia. Int J Womens Health. 2017 Jun 16;9:449-454. doi: 10.2147/IJWH.S134088. eCollection 2017
    2. Bernice Asiedu, Yvonne Anang, Adraina Nyarko, Derek Amartey Doku, Brodrick Y. Amoah, Sheila Santa, Robert A. Ngala & George A. Asare (2017). The role of sex steroid hormones in benign prostatic hyperplasia The Aging Male, DOI: 10.1080/13685538.2016.1272101
    3. George Awuku Asare*,Robert A. Ngala, Daniel Afriyie, Samuel Adjei, Adriana Nyarko,,Yvonne Anang-Quartey ,Bernice Asiedu, Derek Doku, Brodrick Y .Amoah Kennedy Bentum, Iddi Musah and Kensese Mossanda, (2017). Calcium - Magnesium imbalance implicated in benign prostatic hyperplasia and restoration by a phytotherapeutic drug–Croton membranaceus Müll.Arg. BMC Complementary and Alternative Medicine
    4. Robert A. Ngala, Martin A Awe, Paul Nsiah (2017). Anthropometrics Evaluations in Type 2 Diabetes Mellitus Patients, with and Without Metabolic Syndrome. A Case Control Study. Savant Journal of Medicine and Medical Sciences. Vol 3(1) pp. 001-014 March, 2017
    5. Sheila Santa, Bernice Asiedu, Robert A. Ngala, Jonathan Kofi Adjei Maria Anyorikeya Brodrick Y. Amoah and George  Asare1*. (2016). Chronic Use of Hormonal   Contraceptives and its Impact on Cardiovascular Risk. British Journal of Medicine & Medical Research17(4): 1-11, 2016, Article no.BJMMR.26391
    6. A. Dickson, B. K. Harley, D. Berkoh, R.A. Ngala, N.A. Titiloye and T.C. Fleischer (2016). Antidiabetic and haematological effect of Myrianthus Arboreus  P. Beauv. stem bark extract in streptozotocin - induced diabetic rats International Journal of Pharmaceutical Sciences and Research (IJPSR), Vol. 7(12): 4812-4826. 
    7. A. Ngala, F. A. Yeboah, A. T. Bawah*H. Alidu and M. M. Seini (2016).Maternal adiposity and serum visfatin levels during first trimester among pregnant women with preeclampsia. Int. J. Adv. Res. 4(8),  960-966
    8. A. Yeboah,R. A. Ngala*, A. T. Bawah, H. Mbroh (2016).Maternal Adiposity And Serum Leptin Levels at 11–13 Weeks of Gestation Among Pregnant Women With Gestational Diabetes Mellitus Int J Med Health SciOct 2016,Vol-5;Issue-4
    9. 12.Robert A. Ngala, Isaac Ampong , Samuel Asamoah Sakyi and Enoch Odame Anto.(2016).Effect of dietary vegetable oil consumption on blood glucose levels, lipid profile and weight in diabetic mice: an experimental case—control study BMC Nutrition (2016) 2:28
    10. 13.Obirikorang, E. O. Anto, R. A. Ngala *, E. Gyamfi (2015). The prevalence of childhood obesity and lifestyle-associated risk factors using anthropometric measurements among primary schools in the Kumasi metropolis-Ghana. International Journal of Innovative Medicine and Health Science, Vol. 4, 2015, 13-23
    11. 14.Robert A. Ngala, Martin A. Akilla and Edwin D. Doodaah (2015). Are the Thigh Circumference, Waist-to-Thigh Circumference Ratio and Serum Creatinine Better Markers of Type II Diabetes than the Body Mass Index? Trends in Medical Research 10 (2): 26-36, 2015ISSN 1819-3587 / DOI: 10.3923/tmr.2015.26.36© 2015 Academic Journals Inc
    12. 15.Asare, G A. Afriyie D., Ngala, R A., Appiah, A A., Anang, Y., Musah, I., Adjei, S., Bamfo-Quaicoe K Sule, D.,  Gyan, B A.,   Arhin, P., and Edoh D A.(2015) Shrinkage of Prostate and Improved Quality of Life: Management of BPH Patients with Croton membranaceus  Ethanolic Root Extract Evidence-Based Complementary and Alternative Medicine vol 2015        http;//dx.doi.0r/10.1155/2015/365205
    13. 16.Robert A. Ngala, Michael B. Yakass, K. Bedu-Addo and Edem K. Hiadzi (2015). Effect of Basal Gonadotropins, Prolactin and Anthropometry as Predictive Markers of Ovarian Response in Patients Seeking Assisted Reproduction Trends in Medical Research 10 (4): 75-86, 2015ISSN 1819-3587 / DOI: 10.3923/tmr.2015.75.86© 2015 Academic Journals Inc.17.
    14. Robert A. Ngala, Mohamed S. Zaibi, Kenneth Langlands, Claire J. Stocker, Jonathan R.S. Arch and Michael A. Cawthorne (2014). Stimulation of glucose uptake in murine soleus muscle and adipocytes by5-(4- phenoxybutoxy)psoralen (PAP-1) PeerJ, DOI 10.7717/peerj.614
    15. 18.George A Asare , Sheila Santa, Robert A Ngala, Bernice Asiedu, Daniel Afriyie, Albert G.B Amoah. (2014).Effect of hormonal contraceptives on lipid profile and the risk indices for cardiovascular disease in a Ghanaian community International Journal of Women’s Health :6 597-603
    16. 19.Robert A Ngala, David Opoku and George Asare (2014). Effect of HIV infection and Antiretroviral Therapy (HAART) on the liver of HIV patients. Trends in Medical Research 10.3923/TMR2014
    17. 20.Robert A Ngala and Albert Adu Asare (2014). Influence of oxidative stress, skeletal muscle mass and obesity on type 2 diabetes among patients in Kumasi metropolis Trends in Medical Research 10.3923/TMR2014
    18. Robert A Ngala and Klutse Fianko (2014). Effect of HIV infection and Antiretroviral Therapy on cardiovascular Risk Factor  Tre
    19. 22.. Ngala, Robert A.; O'Dowd, Jacqueline; Wang, Steven J.; Stocker, Claire; Cawthorne, Michael A.; Arch, Jonathan R.S (2013). β2-adrenoceptor agonists can both stimulate and inhibit glucose uptake in mouse soleus muscle through ligand-directed signaling Naunyn-Schmiedeberg's Arch Pharmacol DOI 10.1007/s00210-013-0860-5
    20. 23. R A Ngala, Osei Sadique and PK Gmagna (2013). Effect of Exercise on lipid profile and oxidative stress in patients with Type 2 Diabetes Mellitus. American journal OF Drug Discovery and Development ISSN 2150-427X/DOI: 10.3923/AJDD.2013
    21. 24. Robert A Ngala and Klutse Fianko (2013). Effect of HIV infection and Antiretroviral Therapy on cardiovascular Risk Factor Trends in Molecular Sciences DOI: 10.3923/tms.2013
    22. 25. Mohamed Bellahcene1,3, Jacqueline O’Dowd1, Ed T Wargent1, Mohamed S Zaibi1, David Hislop1, Robert A Ngala1,4, David M Smith2, Michael A Cawthorne1, Claire J Stocker1, Jonathan R S Arch1 (2012)
    23. 26.Male mice that lack GPR41 have low energy expenditure and increased body fat content. British journal of Nutrition 1-10 doi:1017/S00071145120033923
    24. R.A. Ngala, Stocker CJ, Roy AG, Hislop D, Wargent E, Bell R, Hassall DG, Harling JD, Billin AN, Willson TM, Arch JR, Cawthorne MA. (2011). A new, highly selective murine peroxisome proliferator-activated receptor δ agonist increases responsiveness to thermogenic stimuli and glucose uptake in skeletal muscle in obese mice. Diabetes Obes Metab. Jan 27. doi: 10.1111/j.1463-1326.2011.01371.x. [Epub ahead of print]
    25. 28. R.A. Ngala, Stocker C, Arch JRS, Cawthorne MA (2011). Is the combination of b3-AR agonist and PPAR agonists a better treatment of type II diabetes and obesity? Journal of the Ghana Science Association vol 13 2, 20-29
    26. 29. R.A. Ngala, C. Stocker, M.V. Sennitt, E. Wargent, J.R.S. Arch, M.A. Cawthorne (2010). The effects of ppar delta and alpha agonist on fatty acid and glucose metabolism in vivo and in mouse isolated soleus muscle Journal of the Ghana Science Association vol. 12 1 114-124
    27. 30. R.A. Ngala, J.R.S. Arch, M.A. Cawthorne (2010). Clenbuterol-stimulated glucose uptake activates both gs and gi pathways through β2-adrenoceptor in mouse isolated soleus muscle Journal of the Ghana Science Association ) vol 12 no 2 110-117
    28. 31. Ngala, Robert A.; O'Dowd, Jacqueline; Wang, Steven J.; Stocker, Claire; Cawthorne, Michael A.; Arch, Jonathan R.S. (2009). β2-Adrenoceptors and non-β-adrenoceptors mediate effects of BRL37344 and clenbuterol on glucose uptake in soleus muscle: studies using knockout mice : British Journal of Pharmacology, Volume 158, Number 7, December 2009 , pp. 1676-1682(7)
    29. 32. R.A. Ngala, Stocker C, Arch JRS, Cawthorne MA (2009). b3-Adrenoceptor Mediates b3-Selective agonist-induced effects on energy expenditure, insulin secretion and food intake Journal of Ghana Science Association vol. 11 No 1 116-127.

      ABSTRACTS /CONFERENCE PROCEDINGS

      1. Ngala R. A, Steven J Y Wang, Claire Stocker, Michael A Cawthorne, Jonathan R.S Arch. Involvement of Gs and Gi proteins and PI3Kinase in clenbuterol and BRL-37344-stimulated glucose uptake in soleus muscle British Pharmacological Society http;//pA2online.org ( Accessed 20 June 2009)
      2. Ngala R.A. , Stocker C, Arch JRS, Cawthorne MA (2009) Signalling transduction mechanism of BRL37344 and Clenbuterol-stimulated glucose uptake in mouse isolated soleus muscle IDF 2009 Abstract book pp 421
      3. Ngala R A. Why are thin people not fat? Second Annual Scientific Conference (College of Health Science, KNUST) Book of Abstract 10-11 Sept 2009.
      4. Ngala R A. Martin A Akilla (2011). Is the waist to thigh ratio a stronger marker of Type two diabetes than BMI and waist circumference? Ghana Science Association book of abstract July 2011
      5. Ngala R. A. Peter Gmagna (2011). Effect of exercise on diabetes mellitus management Ghana Science Association book of abstract July 2011.

    PUBLICATIONS

    1. Robert A Ngala and Albert Adu Asare (2014). Influence of oxidative stress, skeletal muscle mass and obesity on type 2 diabetes among patients in Kumasi metropolis Trends in Medical Research DOI. 10.3923/TMR2014
    2. Robert A Ngala and KlutseFianko (2014). Effect of HIV infection and Antiretroviral Therapy on cardiovascular Risk Factor Trends in Molecular Sciences 6 (1):1-12
    3. Ngala, Robert A.; O'Dowd, Jacqueline; Wang, Steven J.; Stocker, Claire; Cawthorne, Michael A.; Arch, Jonathan R.S (2013). β2-adrenoceptor agonists can both stimulate and inhibit glucose uptake in mouse soleus muscle through ligand-directed signalingNaunyn-Schmiedeberg's Arch PharmacolDOI 10.1007/s00210-013-0860-5
    4. R ANgala, OseiSadique and PK Gmagna (2013). Effect of Exercise on lipid profile and oxidative stress in patients with Type 2 Diabetes Mellitus. American journal of Drug Discovery and Development ISSN 2150-427X/DOI: 10.3923/AJDD.2013
    5. Mohamed Bellahcene1,3, Jacqueline O’Dowd1, Ed T Wargent1, Mohamed S Zaibi1, David Hislop1, Robert A Ngala1,4, David M Smith2, Michael A Cawthorne1, Claire J Stocker1, Jonathan R S Arch1 (2012) Male mice that lack GPR41 have low energy expenditure and increased body fat content. British journal of Nutrition1-10 doi;1017/S0071145120033923
    6. R.A. Ngala, Stocker CJ, Roy AG, Hislop D, Wargent E, Bell R, Hassall DG, Harling JD, Billin AN, Willson TM, Arch JR, Cawthorne MA. (2011). A new, highly selective murine peroxisome proliferator-activated receptor δ agonist increases responsiveness to thermogenic stimuli and glucose uptake in skeletal muscle in obese mice.Diabetes ObesMetab. DOI;10.1111/J.1463-1326.2011.01371.X.
    7. R.A. Ngala, Stocker C, Arch JRS, Cawthorne MA(2011). Is the combination of b3-AR agonist and PPAR agonists a better treatment of type II diabetes and obesity? Journal of Ghana Science Association vol 13 2 20-29
    8. R.A. Ngala, C. Stocker, M.V. Sennitt, E. Wargent, J.R.S. Arch, M.A. Cawthorne (2010). The effects of ppar delta and alpha agonist on fatty acid and glucose metabolism in vivo and in mouse isolated soleus muscle Journal of Ghana Science Association vol 12 1 114-124
    9. R.A. Ngala, J.R.S. Arch, M.A. Cawthorne (2010). Clenbuterol-stimulated glucose uptake activates both gs and gi pathways through β2-adrenoceptor in mouse isolated soleus muscle Journal of Ghana Science Association vol 12 2 110-117
    10. Ngala, Robert A.; O'Dowd, Jacqueline; Wang, Steven J.; Stocker, Claire; Cawthorne, Michael A.; Arch, Jonathan R.S. (2009) β2-Adrenoceptors and non-β-adrenoceptors mediate effects of BRL37344 and clenbuterol on glucose uptake in soleus muscle: studies using knockout mice British Journal of Pharmacology, Volume 158, Number 7, December 2009 , pp. 1676-1682(7).
    11. R.A. Ngala, Stocker C, Arch JRS, Cawthorne MA (2009). b3-Adrenoceptor Mediates b3-Selective agonist-induced effects on energy expenditure, insulin secretion and food intake Journal of Ghana Science Association vol. 11 No 1 116-127
    12. Robert A. Ngala, Steven J. Wang, Anurag Agarawal, Jacqueline O’ Down, Claire Stocker Michael A. Cawthorne , Jonathan R.S. Arch. (2008) Metabolic response to BRL-37344 and clenbuterol in soleus muscle and C2C12 cells via different atypical pharmacologies and β-adrenoceptor mechanism British journal of pharmacology 155 395-406
    13. R. A. Ngala, M.T.Frimpong, E.F. Laing, W.K.B.A. Owiredu. (2001) Lipid lowering among treated hypertensives in a Ghanaian population Journal of Ghana Science Association vol 3no 2
    14. M.T Frempong RA Ngala FA Yeboah Electrolyte monitoring in management of essential hypertension Journal of Ghana Science Association
    vol.2 2000

      CONFERENCES/WORKSHOPS ATTENDED

    1. 21st biennial conference of Ghana Science Association (Accra) 2000
    2. 22nd biennial conference of Ghana Science Association (Cape Coast) 2001
    3. 18th International Diabetes Federation Congress- Paris 24-29th August 2003
    4. Diabetes Conference: University of Buckingham (UK) 4th -7th October 2003
    5. Days of Molecular Medicine, The UCSD institute of Molecular Medicine: The Welcome Trust and Nature Medicine March 18-20th 2004 University of Cambridge –UK
    6. Fourth Congress of the FEDRATION of Pharmacological Societies (EPHAR)14-17TH July 2004 Porto –Portugal
    7. Fourth Focus Meeting: Cell signaling: British Pharmacological Society (BPS) 11th -12th April 2005. Leicester –UK
    8. First Annual Scientific Conference; The College of Health Sciences 28th -29th August 2007 -Kumasi
    9. 20th World Diabetes Congress, Montreal. Canada 18-22 Oct 2009 (Presented Poster on the topic: Signal transduction Mechanism of BRL 37344 and clenbuterol stimulated glucose uptake in mouse isolated skeletal muscle)
    10. Second Annual Scientific Conference (College of Health Science, KNUST) 10-11 Sept 2009 (Audio Visual/ Oral Presentation on the topic; Why are thin people not fat?)
    11. Third Annual Scientific Conference (College of Health Science, KNUST) 10-11 Sept 2010
    12. Fourth Annual Scientific Conference (College of Health Science, KNUST) 10-11 Sept 2011
    13. 27th Biennial Conference Ghana Science Association (Kumasi) 10-15 July 2011
    14. STEM conference KNUST/ KUMASI (MAY 29-31 2012)
    15. MEPI Workshop South Africa 5-8 June 2012
    16. Allied Health Week KNUST/SMS. Guest Speaker, R.A Ngala: Combating the lifestyle: Diabetic Menace; The role of Allied Health Scientist 29/2/2012
    17. Workshop for Provost, Registrars, Deans and Heads of Department.
    Leadership, financial management, discipline of staff and student (19th -21st February 2013)

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