Prof. Sampson Antwi

Professor


Dept: Child Health
Department of Child Health,
School of Medicine and Dentistry
KNUST/Komfo Anokye Teaching Hospital
Kumasi

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Research Areas/Interests

By way of medical research, my interest is in three (3) areas: Paediatric renal diseases Paediareic HIV diseases Paediatric malnutrition ...~more

My full CV

Publications

    1. Etty Kruzel-Davila, Barbara Mensah Sankofi, Ernestine Amos-Abanyie Kubi, Anita Ghansah, Alexander Nyarko, Seth Agyemang, Gordon A Awandare, Szwarcwort Moran, Anat Reiner-Benaim, Basem Hijazi, Ifeoma Ulasi, Yemi Raheem Raji, Vincent Boima, Charlotte Osafo, Victoria Adabayeri, Michael Matekole, Timothy O Olanrewaju, Samuel Ajayi, Manmak Mamven, Sampson Antwi, Ademola Adebowale, Jacob Plange-Rhule, Fatiu Arogundade, Priscilla Abena Akyaw, Cheryl Ann Winkler, Babatunde L Salako, Akinlolu Ojo, Karl Skorecki and Dwomoa Adu. HIV viremia is associated with APOL1 variants and reduced JC-viruria. Front. Med. – Nephrology. Aug. 2021 (In Press).

     2. Banerjee Sushmita, Nivedita Kamath, Sampson Antwi, Melvin Bonilla-Felix. Paediatric nephrology in under-resourced areas. Pediatric Nephrology https://doi.org/10.1007/s00467-021-05059-y.  

     3. Sampson Antwi and Mohammed Duah Issahalq (March 17th 2021). Hearing Loss in Chronic Kidney Disease [Online First], IntechOpen, DOI: 10.5772/intechopen.96572. Available from: https://www.intechopen.com/online-first/hearing-loss-in-chronic-kidney-disease

     4. N. A. H. Seneadza, S. Antwi, H. Yang, A. Enimil, A. Dompreh, L. Wiesner, C. A. Peloquin, M. Lartey, M. Lauzardo, A. Kwara. Effect of malnutrition on the pharmacokinetics of anti-TB drugs in Ghanaian children. INT J TUBERC LUNG DIS 25(1):36–42 Q 2021 The Union http://dx.doi.org/10.5588/ijtld.20.0301

     

     5. Nourse P, Cullis B, Finkelstein F, Numanoglu A, Warady B, Antwi S, McCulloch M.
    ISPD guidelines for peritoneal dialysis in acute kidney injury: 2020 Update (paediatrics).
    Perit Dial Int. 2021 Feb 1:896860820982120. doi: 10.1177/0896860820982120. Online ahead of print.PMID: 33523772

     6. Esezobor C, Ademola AD, Adetunji AE, Anigilaje EA, Batte A, Jiya-Bello FN, Furia FF, Muoneke U, McCulloch M, Nourse P, Obiagwu P, Odetunde O, Okyere P, Solarin A, Tannor EK, Noone D, Gbadegesin R, Parekh R, and the H3 Africa Kidney Disease Research Network*. Management of idiopathic childhood nephrotic syndrome in Sub-Saharan Africa: Ibadan consensus statement. Kidney Int (In Press)

     7. Antwi S. Clean water to prevent kidney disease. Nat Rev Nephrol. 2020 Nov 19. doi: 10.1038/s41581-020-00374-3. Online ahead of print.PMID: 33214702 No abstract available.

     8. Farthing H, Reynolds NR, Antwi S, Alhassan A, Ofori IP, Renner L, Amissah KA, Kusah JT, Lartey M, Paintsil E; Sankofa Study Team. Illness Narratives of Children Living with HIV Who Do Not Know Their HIV Status in Ghana: I'm Sick, But I Don't Know the Sickness-A Qualitative Study. .AIDS Behav. 2020 Nov;24(11):3225-3231. doi: 10.1007/s10461-020-02884-4.PMID: 32333207

     9. Paintsil E, Kyriakides TC, Antwi S, Renner L, Nichols JS, Amissah K, Kusah JT, Alhassan A, Ofori IP, Catlin AC, Gan G, Lartey M, Reynolds NR. Clinic-Based Pediatric Disclosure Intervention Trial Improves Pediatric HIV Status Disclosure in Ghana. J Acquir Immune Defic Syndr. 2020 May 1;84(1):122-131. doi: 10.1097/QAI.0000000000002316. PMID:32049772

    10. Sood S, Ojo AO, Adu D, Kannan K, Ghassabian A, Koshy T, Vento SM, Pehrson LJ, Gilbert JF, Arogundade FA, Ademola AD, Salako BO, Raji Y, Osafo C, Antwi S, Trachtman H, Trasande L; H3Africa Kidney Disease Research Network Investigators. Association Between Perfluoroalkyl Substance Exposure and Renal Function in Children With CKD Enrolled in H3Africa Kidney Disease Research Network. Kidney Int Rep. 2019 Aug 6;4(11):1641-1645. doi: 10.1016/j.ekir.2019.07.017. eCollection 2019 Nov. PMID:31891007

     11.Antwi S.Hearing loss in patients with chronic kidney disease and psychological burden in their caregivers. Ghana Med J. 2019 Sep;53(3):189. doi: 10.4314/gmj.v53i3.1.

     12. Anthony Enimil, Sampson Antwi, Hongmei Yang, Albert Dompreh , Wael A. Alghamdi, Fizza S. Gillani, Antoinette Orstin, Dennis Bosomtwe, Theresa Opok , JenniferNorman, Lubbe Wiesner, Taimour Langaee, Charles A. Peloquin, Michael H. Court , DavidJ. Greenblatt, Awewura Kwara. Effect of first-line antituberculosis therapy on nevirapine pharmacokinetics in children  younger than 3 years old. Antimicrob. Agents Chemother. doi:10.1128/AAC.00839-19. Accepted Manuscript Posted Online 22 July 2019

    13.Wael A. Alghamdi, Sampson Antwi, Anthony Enimil, Hongmei Yang, Albert Dompreh,Lubbe Wiesner, Taimour Langaee, Charles A. Peloquin and Awewura Kwara. Population pharmacokinetics of efavirenz in HIV and TB/HIV coinfected children: the significance of genotype-guided dosing. J Antimicrob Chemother May 2019. doi:10.1093/jac/dkz238

     14. Kwara A, Yang H, Antwi S, Enimil A, Gillani FS, Dompreh A, Ortsin A, Opoku T, Bosomtwe D, Sarfo A, Wiesner L, Norman J, Alghamdi WA, Langaee T, Peloquin CA, Court MH, Greenblatt DJ. Effect of Rifampin-Isoniazid-Containing Antituberculosis Therapy on Efavirenz Pharmacokinetics in HIV-Infected Children 3 to 14 Years Old. Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01657-18. doi: 10.1128/AAC.01657-18. Print 2019 Jan.PMID: 30397066

    15. Ofori-Atta A, Reynolds NR, Antwi S, Renner L, Nichols JS, Lartey M, Amissah K, Tettey JK, Alhassan A, Ofori IP, Catlin AC, Gan G, Kyriakides TC, Paintsil E, On Behalf Of The Sankofa Study Team. Prevalence and correlates of depression among caregivers of children living with HIV in Ghana: findings from the Sankofa pediatric disclosure study. AIDS Care. 2018 Oct 25:1-10. doi: 10.1080/09540121.2018.1537463. [Epub ahead of print] PMID: 30360643

    16. Nichols JS, Kyriakides TC, Antwi S, Renner L, Lartey M, Seaneke OA, Obeng R, Catlin AC, Gan G, Reynolds NR, Paintsil E, On Behalf Of The Sankofa Study Team.High prevalence of non-adherence to antiretroviral therapy among undisclosed HIV-infected children in Ghana.AIDS Care. 2018 Sep 20:1-10. doi: 10.1080/09540121.2018.1524113. [Epub ahead of print] PMID:30235940

     17. Plange-Rhule J, Kerry SM, Eastwood JB, Micah FB, Antwi S, Cappuccio FP. Blood Pressure and Haematological Indices in Twelve Communities in Ashanti, Ghana. Int J Hypertens. 2018 Apr 5;2018:5952021. doi: 10.1155/2018/5952021. eCollection 2018. PMID:29850225

     18.Horita Y, Alsultan A, Kwara A, Antwi S, Enimil A, Ortsin A, Dompreh A, Yang H, Wiesner L, Peloquin CA. Evaluation of the Adequacy of WHO Revised Dosages of the First-Line Antituberculosis Drugs in Children with Tuberculosis Using Population Pharmacokinetic Modeling and Simulations. Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00008-18. doi: 10.1128/AAC.00008-18. Print 2018 Sep. PMID: 29914960

     19. Elliot Tannor, Yaw Awuku, Vincent Boima, Sampson Antwi. (2018). The geographical distribution of dialysis services in Ghana. Renal Replacement Therapy.4:3 DOI 10.1186/s41100-018-0143-1

    20. Dompreh A, Tang X, Zhou J, Yang H, Topletz A, Adu Ahwireng E, Antwi S, Enimil A, Langaee T, Peloquin CA, Court MH, Kwara A. Effect of Genetic Variation of NAT2 on Isoniazid and SLCO1B1 and CES2 on Rifampin Pharmacokinetics in Ghanaian Children with Tuberculosis. Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02099-17. doi: 10.1128/AAC.02099-17

    21. Yang H, Enimil A, Gillani FS, Antwi S, Dompreh A, Ortsin A, Adu Awhireng E, Owusu M, Wiesner L, Peloquin CA, Kwara A. Evaluation of the Adequacy of the 2010 Revised World Health Organization Recommended Dosages of the First-line Antituberculosis Drugs for Children: Adequacy of Revised Dosages of TB Drugs for Children. Pediatr Infect Dis J. 2018 Jan;37(1):43-51. doi: 10.1097/INF.0000000000001687

     22. Abdou N,Antwi S, Koffi LA, Lalya F, Adabayeri VM, Nyah N, Palmer D, Brusselmans A, Cullis B, Feehally J, McCulloch M, Smoyer W, Finkelstein FO. Peritoneal Dialysis to Treat Patients with Acute Kidney Injury-The Saving Young Lives Experience in West Africa: Proceedings of the Saving Young Lives Session at the First International Conference of Dialysis in West Africa, Dakar, Senegal, December 2015.Perit Dial Int. 2017 Mar-Apr;37(2):155-158. 

     23. Antwi S, Yang H, Enimil A, Sarfo AM, Gillani FS, Ansong D, Dompreh A, Orstin A, Opoku T, Bosomtwe D, Wiesner L, Norman J, Peloquin CA, Kwara A. Pharmacokinetics of the First-Line Antituberculosis Drugs in Ghanaian Children with Tuberculosis with or without HIV Coinfection. Antimicrob Agents Chemother. 2017 Jan 24;61(2). pii: e01701-16.

    24. Morgan Congdon, Annie Gjelsvik, Mark Lurie, Anthony Enimil, Sampson Antwi, AwewuraKwara. The role of nutritional status on follow-up among HIV- infected children at a Teaching Hospital Clinic in Ghana. West Afr J Med. 2015. Jan-March;29(1):20-26

    25. Enimil A, Nugent N, Amoah C, Norman B, Antwi S, Ocran J, Kwara A, Barker DH. Quality of life among Ghanaian adolescents living with perinatally acquired HIV: a mixed methods study.AIDS Care. 2015 Dec 7:1-5

    26. Ann Christine Catlin, Sumudinie Fernando, Ruwan Gamage, Lorna Renner, Sampson Antwi, Jonas Kusah Tettey, Kofi Aikins Amisah, Tassos Kyriakides, Xiangyu Cong, Nancy Reynolds, and Elijah Paintsil on Behalf of the Sankofa Project Team. Disclosure Special Issue: Sankofs Pediatric HIV disclosure Intervention Cyber Data Management: Building Capacity in a Resource-limited Setting and Ensuring Data Quality. AIDS Care 2015 Dec;27 Suppl 1:99-107

    27. Elijah Paintsil, Lorna Renner, Sampson Antwi, Joycelyn Dame, Anthony Enimil, Angela Ofori-Atta, Amina Alhassan, Irene Pokuaa Ofori, Xiangyu Cong, Tassos Kyriakides, and Nancy Reynolds. HIV Knowledge, Stigma and Illness Beliefs among Pediatric Caregivers’ in Ghana who have not Disclosed their Child’s HIV Status. AIDS Care 2015 Dec;27 Suppl 1:18-27

    28. Antwi S, Sarfo A., Amoah A, Appia SA,Obeng E. Acute Kidney Injury in Children: 3-Year Data Review from Ghana. Int J Pediatr Res 2015, 1:2

    29. Awewura Kwara, Anthony Enimil, Fizza Gillani, Hongmei Yang, Amina Sarfo, Albert Dompreh, Antoinette Ortsin, Lawrence Osei-Tutu, Sandra Kwarteng Owusu, Lubbe Wiesner, Jennifer Norman, Jaclynn Kurpewski, Charles Peloquin, Daniel Ansong, Sampson Antwi. Pharmacokinetics of First-line Antituberculosis Drugs Using WHO Revised Dosage in Children with Tuberculosis with and without HIV Coinfection. Journal of the Pediatric Infectious Disease Society. May 2015.pp1-10

    30. Antwi S, Aboah KE, Sarpong CK.The Unacknowledged Impact of Urinary Schistosomiasis in Children: 5 cases from Kumasi-Ghana. Ghana Med J. 2014 Dec;48(4):228-33.

    31. Ocheke IE, Antwi S, Gajjar P, McCulloch IM, Nourse P. Pelvi-Ureteric Junction Obstruction at Red Cross Children’s Hospital, Cape Town: a six-year review. AJNT 2014. 7(1)33-36

    32. Callegari J, Antwi S, Wystrychowski G, Zukowska-Szczechowska E, Levin NW, Carter M. Peritoneal dialysis as a mode of treatment for acute kidney injury in sub-saharan Africa. Blood Purif. 2013;36(3-4):226-30. Epub 2013 Dec 20.

    33. Asafo-Agyei SB, Antwi S, Nguah SB. HIV infection in severely malnourished children in Kumasi, Ghana: a cross-sectional prospective study. BMC Pediatr. 2013 Nov 9;13(1):181

    34. Timmann C, Thye T, Vens M, Evans J, May J, Ehmen C, Sievertsen J, Muntau B, Ruge G, Loag W, Ansong D, Antwi S, Asafo-Adjei E, Nguah SB, Kwakye KO, Akoto AO, Sylverken J, Brendel M, Schuldt K, Loley C, Franke A, Meyer CG, Agbenyega T, Ziegler A, Horstmann RD. . Genome-wide association study indicates two novel resistance loci for severe malaria. Nature. 2012:443-6.

    35. Ansong D, Asante KP, Vekemans J, Owusu SK, Owusu R, Brobby NA, Dosoo D, Osei-Akoto A, Osei-Kwakye K, Asafo-Adjei E, Boahen KO, Sylverken J, Adjei G, Sambian D, Apanga S, Kayan K, Janssens MH, Lievens MJ, Olivier AC, Jongert E, Dubois P, Savarese BM, Cohen J, Antwi S, Greenwood BM, Evans JA, Agbenyega T, Moris PJ, Owusu-Agyei S. T Cell Responses to the RTS,S/AS01(E) and RTS,S/AS02(D) Malaria Candidate Vaccines Administered According to Different Schedules to Ghanaian Children. PLoS One. 2011 Apr 27;6(4):e18891.

    36. Antwi S. Assessment and Management of severe malnutrition in children. West Afr J Med. 2011 Jan-Feb;30(1):11-18.

    37. Lalya F, Ocheke IE, Hounnou-d’Almeida, Sagbo G, Alao J, Antwi S, Ayivi B, Koumakpai S. Paediatric tuberculosis at the National Teaching Hospital CNHU-HKM of Cotonou, Bein: A review. West Afr J Med. 2010 Jul-Aug;29(4):263-266

    38. Eastwood JB, Kerry SM, Plange-Rhule J, Micah FB, Antwi S, Boa FG, Banerjee D, Cappuccio FP. Assessment of GFR by four methods in adults in Ashanti, Ghana: the need for an eGFR equation for lean African populations. Nephrol Dial Transplant. 2010 Jan 25

    39. Reynolds NR, Ofori-Atta A, Lartey M, Renner L, Antwi S, Enimil A, Catlin AC, Fernando S, Kyriakides TC, Paintsil E. Sankofa: a multisite collaboration on paediatric HIV disclosure in Ghana. AIDS. 2015 Jun;29Suppl 1:S35-45

    40. Antwi S. State of Renal Replacement Therapy in Ghana. Blood Purif. 2015;39(1-3):137-40

    41. Antwi S. Peritoneal Dialysis using improvised PD catheter and self-constituted dialysis solution. Pediatr Nephrol (Sept 2010). 25:1938 (Abstract).

     42. Antwi S, McCulloch M, Gajjar P, Nourse P. Audit of Posterior Urethral valve at Red Cross Children’s Hospital. Pediatr Nephrol (Sept 2010). 25:1964 (Abstract).

     43. Antwi S, P. Gajjar, H. Burger, P. Sinclair, P. Nourse, l. Savage, I. Ocheke, M. McCulloch, J. Wiggelinkhuizen, D. Maythem, G. Van Dauteren, C. Morrison. Epidemiology/Aetiology of ESRF among renal transplant recipients at red cross children’s hospital. Pediatr Nephrol (Sept 2008). 24:1879 (Abstract).

     44. Owusu-Agyei S, Ansong D, Asante K, Kwarteng Owusu S, Owusu R, Wireko Brobby NA, Dosoo D, Osei Akoto A, Osei-Kwakye K, Adjei EA, Boahen KO, Sylverken J, Adjei G, Sambian D, Apanga S, Kayan K, Vekemans J, Ofori-Anyinam O, Leach A, Lievens M, Demoitie MA, Dubois MC, Cohen J, Ballou WR, Savarese B, Chandramohan D, Gyapong JO, Milligan P, Antwi S, Agbenyega T, Greenwood B, Evans J. Randomized controlled trial of RTS,S/AS02D and RTS,S/AS01E malaria candidate vaccines given according to different schedules in Ghanaian children. PLoS One. 2009 Oct 2;4(10):e7302.

     45. Antwi S. Malnutrition: missed opportunities for diagnosis. Ghana Med J. 2008 Sep;42(3):101-4.

     46. Antwi S, Bates I, Baffoe-Bonnie B, Critchley J. Urine dipstick as a screening test for urinary tract infection. Ann Trop Paediatr. 2008 Jun;28(2):117-22

     47. Evans JA, May J, Ansong D, Antwi S, Asafo-Adjei E, Nguah SB, Osei-Kwakye K, Akoto AO, Ofori AO, Sambian D, Sylverken J, Busch W, Timmann C, Agbenyega T, Horstmann RD. Capillary refill time as an independent prognostic indicator in severe and complicated malaria. J Pediatr. 2006 Nov;149(5):676-81

     48. Kerry SM, Emmett L, Micah FB, Martin-Peprah R, Antwi S, Phillips RO, Plange-Rhule J, Eastwood JB, Cappuccio FP. For the patient. How much salt is used in Ashanti, West Africa?Ethn Dis. 2005 Winter;15(1):150-1.

    49. Kerry SM, Emmett L, Micah FB, Martin-Peprah R, Antwi S, Phillips RO, Plange-Rhule J, Eastwood JB, Cappuccio FP. Rural and semi-urban differences in salt intake, and its dietary sources, in Ashanti, West Africa. Ethn Dis. 2005 Winter;15(1):33-9.

     50. Cappuccio FP, Micah FB, Emmett L, Kerry SM, Antwi S, Martin-Peprah R, Phillips RO, Plange-Rhule J, Eastwood JB. Prevalence, detection, management, and control of hypertension in Ashanti, West Africa. 2004 May;43(5):1017-22. Epub 2004 Mar 22.

     51. Charles R.J. Clarissa Valim, Sanjeev Krishna, David Wypij, Christopher Olola, Tsiri Agbenyega, and Terrie E Taylor, for the Severe Malria in African Children Network (Ghana: Sampson Antwi et al). The prognostic value of Measures of Acid/Base Balance in Pediatric Falciparum Malaria Malaria, Compared with other Clinical and Laboratory parameters. Clinical Infectious Disease 2005; 41: 948-57.

     52. Olola CH, Missinou MA, Issifou S, Anane-Sarpong E, AbubakariI, Gandi JN, Chagomerana M, Pinder M, Agbenyega T, Kremsner PG, Newton CR, Wypij D, Taylor TE: SMAC Network (Ghana: Sampson Antwi et al). Medical informatics in medical research-the Severe Malaria in African Children (SMAC) Networks experience. 2006; 45(5)483-91

     53. Terrie Taylor, Christopher Olola, Clarissa Valim, Tsiri Agbenyega, Peter Kremsner, Sanjeev Krishna, Dominic Kwiatkowski, Charles Newton, Michael Missinou, Magaret Pinder, David Wypij, and on behalf of the SMAC network (Ghana: Sampson Antwi et al). Standardized data collection for multi-centre clinical studies of severe malaria in African children: establishing the SMAC network. Trans R Soc Trop Med Hyg. 2006 July; 100(7):615-622.

     

     

     


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