Prof. Alex Osei-Akoto

Professor


Dept: Child Health
Department of Child Health
School of Medicine and Dentistry

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Research Areas/Interests

General Paediatics with special interest in clinical malaria. Also interested in Paediatric haematology with special interest in Sickle Cell Disease &...~more

My full CV

Publications

    Publications:

     

     

    1

    Opare-Sem O, Bedu-Addo G, Karikari P, Boateng P, Sarkodie F, Rahman R, Asenso-Mensah K, Awuah B, Osei Akoto A, Munin SA, Mensah-Acheampong F, Allain JP, Owusu-Ofori S. Fourteen-year experience of a tertiary hospital transfusion committee in West Africa.

    Transfusion. 2014 May 20. doi: 10.1111/trf.12690

    2

    Ansong D, Osei-Akoto A, Owusu SK, Boakye I, Nguah SB, Sambian DJ, Sylverken J, Arhin B. Haematological indices, nutritional assessment and mortality outcome of children presenting with severe malaria to a tertiary hospital in Ghana. Journal of Pediatric Sciences. 2013;5:e189

    3

    Ansong D, Osei-Akoto A, Ocloo D, Ohene-Frempong K. Sickle Cell Disease: Management options and challenges in developing countries. Mediterr J Hematol Infect Dis. 2013 Nov 4;5 (1):e2013062.

    4

    Nsiah K, Dzogbefia VP, Ansong D, Osei-Akoto A, and Ocloo D. Some Conventional and non-conventional hematological and biochemical markers for characterizing some acute and chronic presentations of sickle cell patients. J Invest Biochem. 2013;2(1):14-20. DOI:10. 5444/jib.20121217043354.

    5

    Nsiah K., Dzogbefia V.P., Osei-Akoto A., Ansong D. The prevalence of seropositivity to hepatitis B surface antigen and the corresponding hemato-biochemical features in sickle cell patients in Ghana. Journal of Hematological Malignancies, March 2012, Vol. 2, No. 1

    6

    Opoku-Buabeng J, Akoto AO. Hypertrophic Tonsils in Sickle Cell Patients in Ghana. Journal of the West African College of Surgeons. Volume 2 November 3, July-September 2012.

     

    7

    Versporten A, Sharland M, Bielicki J, Drapier N, Vankerckhoven V, Goossens H; ARPEC Project Group Members. The antibiotic resistance and prescribing in European Children project: a neonatal and pediatric antimicrobial web-based point prevalence survey in 73 hospitals worldwide. Pediatr Infect Dis J. 2013 Jun;32(6):e242–253.

    8

    Timmann C, Thye T, Vens M, Evans J, May J, Ehmen C, Sievertsen J, Muntau B, Ruge G, Loag W, Ansong D, Antwi S, Asafo-Adjei E, Nguah SB, Kwakye KO, Akoto AO, Sylverken J, Brendel M, Schuldt K, Loley C, Franke A, Meyer CG, Agbenyega T, Ziegler A, Horstmann RD. Genome-wide association study indicates two novel resistance loci for severe malaria. Nature. 2012 Sep 20;489(7416):443–6.

    9

    Fareed Kow Nanse Arthur, Lawrence Owusu, Francis Agyemang Yeboah, Theresa Rettig and Alex Osei-Akoto. Prognostic significance of biochemical markers in African Burkitt’s lymphoma. Clinical and Translational Oncology. October 2011, Volume 13, Number 10, pg. 731-736,

    10

    Nsiah K, Dzogbefia VP, Ansong D, Akoto AO, Boateng H, Ocloo D. Pattern of AST and ALT changes in relation to hemolysis in sickle cell disease. Clin Med Insights Blood Disord. 2011;2011(4):1–9.

    11

    Ansong D, Alder SC, Crookston BT, Beck C, Gyampomah T, John H. Amuasi, Isaac Boakye, Justice Sylverken, Alex Owusu-Ofori, Devon Hale, Alex Osei Yaw Akoto, Scott R. Larsen (2011) Role of Diagnostic Testing in Schistosomiasis Control Programs in Rural Ghana. J Bacteriol Parasitol 2:115. doi:10.4172/2155-9597.1000115.

    12

    Ansong D, Asante KP, Vekemans J, Owusu SK, Owusu R, Brobby NA, Dosoo D, Osei-Akoto A, Osei-Kwakye K, et al. T cell responses to the RTS,S/AS01(E) and RTS,S/AS02(D) malaria candidate vaccines administered according to different schedules to Ghanaian children. PLoS ONE. 2011;6 (4):e18891.

    13

    Nsiah K, Dzogbefia VP, Ansong D, Boateng H, Ocloo D, Osei-Frempong E, Kena Frempong N, Osei Akoto A. The incidence of malaria and the comparison of Hematological and Biochemical indices of Plasmodium Falciparum-Parasitemic and Aparasitemic sickle cell disease (SCD) patients. Int J Lab Hematol. 2010 Dec;32 (6 Pt 1):e197–207.

    14

    Dondorp AM, Fanello CI, Hendriksen IC, Gomes E, Seni A, Chhaganlal KD, Bojang K, Olaosebikan R, Anunobi N, Maitland K, Kivaya E, Agbenyega T, Nguah SB, Evans J, Gesase S, Kahabuka C, Mtove G, Nadjm B, Deen J, Mwanga-Amumpaire J, Nansumba M, Karema C, Umulisa N, Uwimana A, Mokuolu OA, Adedoyin OT, Johnson WB, Tshefu AK, Onyamboko MA, Sakulthaew T, Ngum WP, Silamut K, Stepniewska K, Woodrow CJ, Bethell D, Wills B, Oneko M, Peto TE, von Seidlein L, Day NP, White NJ; AQUAMAT group. Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial. Lancet. 2010 Nov 13;376(9753):1647–57.

    15

    Owusu L, Yeboah FA, Osei-Akoto A, Rettig T, Arthur FKN.

    Clinical and epidemiological characterisation of Burkitt’s lymphoma: an eight-year case study at Komfo Anokye Teaching Hospital, Ghana. British Journal of Biomedical Science 2010 67 (1

    16

    Crookston BT, Alder SC, Boakye I, Merrill RM, Amuasi JH, Porucznik CA, Stanford JB, Dickerson TT, Dearden KA, Hale DC, Sylverken J, Snow BS, Osei-Akoto A, Ansong D. Exploring the relationship between chronic under nutrition and asymptomatic malaria in Ghanaian children. Malar. J. 2010; 9: 39.

    17

    Owusu-Agyei S, Ansong D, Asante K, Kwarteng Owusu S, Owusu R, Wireko Brobby NA, Dosoo D, Osei Akoto A, Osei-Kwakye K et al. Randomized Controlled Trial of RTS,S/AS02D and RTS,S/AS01E Malaria Candidate Vaccines Given According to Different Schedules in Ghanaian Children. PLoS ONE | www.plosone.org. October 2009 | Volume 4 | Issue 10 | e7302

    18

    Yeboah-Antwi K, Addo-Yobo E, Adu-Sarkodie Y, Carlin JB, Plange-Rhule G, Osei Akoto A, Weber MW, Hamer DH. Clinico-epidemiological profile and predictors of severe illness in young infants (0-59 days) in Ghana Ann Trop Paediatr. 2008 Mar;28(1):35-43.

    19

    Bates I, Ansong D, Bedu-Addo G, Agbenyega T, Akoto AYO, Nsiah-Asare A, et al. Evaluation of a learner-designed course for teaching health research skills in Ghana. BMC Med Educ. 2007;7:18.

    20

    Taylor T, Olola C, Valim C, Agbenyega T, Kremsner P, Krishna S, Kwiatkowski D, Newton C, Missinou M, Pinder M, Wypij D.  Standardized data collection for multi-center clinical studies of severe malaria in African children: establishing the SMAC network. Trans R Soc Trop Med Hyg. 2006 Jul;100(7):615-22.

    21

    Olola CH, Missinou MA, Issifou S, Anane-Sarpong E, AbubakariI, Gandi JN, Chagomerana M, Pinder M, Agbenyega T, Kremsner PG, Newton CR, Wypij D, Taylor TE: SMAC Network. Medical informatics in medical research-the Severe Malaria in African Children (SMAC) Networks experience. Methods Inf Med. 2006; 45(5)_483-91.

    22

    Evans JA, May J, Ansong D, Antwi S, Asafo-Adjei E, Nguah SB, Osei-Kwakye K, Akoto AO, Ofori AO,et al. Capillary refill time as an independent prognostic indicator in severe and complicated malaria. J. Pediatr. 2006 Nov;149(5):676–81.

    23

    Bates I, Akoto AYO, Ansong D, Karikari P, Bedu-Addo G, Critchley J, et al. Evaluating health research capacity building: an evidence-based tool. PLoS Med. 2006 Aug;3(8):e299.

    24

    Martine J. Hollestelle, Cynthia Donkor, Ebenezer Akrofi Mantey, Srabasti J. Chakravorty, Alister Craig, Alex Osei Akoto, James O'Donnell, Jan A. van Mourik, James Bunn (2006) .von Willebrand factor propeptide in malaria: evidence of acute endothelial cell activation
    British Journal of Haematology 133 (5), 562–569.

    25

    Eveline Klinkenberg, P J McCall, Michael D Wilson, Alex O Akoto, Felix P Amerasinghe, Imelda Bates, Francine H Verhoeff, Guy Barnish, Martin J Donnelly. Urban malaria and anaemia in children: a cross-sectional survey in two cities of Ghana. Trop Med Int Health. 2006 May; 11:578-88 16640609

    26

    Lisa Ronald, Sarah Kenny, Eveline Klinkenberg, Alex Akoto,Isaac Boakye, Guy Barnish, Martin Donnelly. Malaria and anaemia among children in two communities of Kumasi, Ghana: a cross-sectional survey. Malar J. 2006 Nov 9;5(1):105 17094806

    27

    1. Osei-Akoto, L Orton, SPO Owusu-Ofori. Atovaquone-proguanil for treating uncomplicated malaria. Cochrane Database of Systematic Reviews2006, Issue 4Copyright © 2006 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 19 October 2005 in Issue 4, 2005

    28

    Management of Accidents and Emergencies. A Manual for Frontline Providers. Series 7. National Health Learning Materials Center, Human Resource Directorate, Ministry of Health/Ghana Health Service. 2003. Chapter 7.

    29

    Saabea Owusu Konadu, Sandra Kwarteng Owusu, Alex Osei-Akoto, Obed Ofori Nyarko, Gilda Opoku, Francis Adjei Osei. Pneumonia dominance in under-five mortalities in sub-Saharan Africa- Urgency for more research and capacity improvement. African Journal of Current Medical Research Vol 3 No 1 (2019) Published October 19,2019

    30

    Nyarko OO, Ansong D, Osei-Akoto A, Konadu SO, Opoku G. Developing Research Competencies of Undergraduate Medical Students in Sub- Saharan Africa. WJMER, Vol 21: Issue 1, 2019

     

    31

    Sonny Michael Assennato, Shirley Owusu-Ofori, Alex Osei-Akoto, Nathalie C. Lambert & Jean-Pierre Allain.  Microchimerism in Ghanaian children recipients of whole blood transfusion for severe anaemia. Vox Sanguinis (2018) 2018. International Society of Blood Transfusion. DOI: 10.

    32

    Lilian A. Boateng, Andrew D. Campbell, Robertson D. Davenport, Alex Osei-Akoto, Sheri Hugan, Akwasi Asamoah, and Henk Schonewille. Red blood cell alloimmunization and minor red blood cell antigen phenotypes in transfused Ghanaian patients with sickle cell disease. TRANSFUSION 2019;9999;1–7.  doi:10.1111/trf.15197

    33

    Makani J, Sangeda RZ, Nnodu O, Nembaware V, Osei-Akoto A, Paintsil V, Balandya E, Kent J, Luzzatto L, Ofori-Acquah S, Olopade OI, Pallangyo K, Minja IK, Jonas M, Mazandu GK, Mulder N, Ohene-Frempong K, Wonkam A. SickleInAfrica. Lancet Haematol. 2020 Feb;7(2):e98-e99. doi: 10.1016/S2352-3026(20)30006-5. PMID:32004491

    34

    Sickle Cell Disease Ontology Working Group. The Sickle Cell Disease Ontology: Enabling Universal Sickle Cell-Based Knowledge Representation. Database, Vol. 2019, Article ID baz118. Published by Oxford University Press

    35

    Anie KA, Paintsil V, Owusu-Dabo E, Ansong D, Osei-Akoto A, Ohene-Frempong K, Amissah KA, Addofoh N, Ackah EB, Owusu-Ansah AT, Ofori-Acquah SF. Organ damage in sickle cell disease study (ORDISS): protocol for a longitudinal cohort study based in Ghana. BMJ Open. 2017 Aug 28;7(8):e016727. doi: 10.1136/bmjopen-2017-016727. PMID: 28851791

    36

    Ashong J, Ansong D, Dogbe J, Osei Akoto A, Amankwa AT, et al. (2016) Case Report on Multiple Pathologies in an Adolescent Sickle Cell Disease Patient in Ghana. Int Clin Pathol J 2(2): 00036. DOI: 10.15406/icpjl.2016.02.00036 

     

    37

    Paintsil V, Dogbe J, Blay NS, Osei-Akoto A, Osei-Tutu L, Hammond C (2015) Pattern of Childhood Cancers Presenting to the Paediatric Cancer Unit of a Tertiary Hospital in Kumasi, Ghana. Journal of Cancer Prevention and Current Research 3(3): 00083. DOI: 10.15406/jcpcr.2015.03.00083  .

    38

    Sylverken J, Robison JA, Osei-Akoto A, Nguah SB, Addo-Yobo E, Balch A, Bolte R, Ansong D. Decreased Mortality After Establishing a Pediatric Emergency Unit at an Urban Referral Hospital in Ghana.

    Pediatr Emerg Care. 2019 Jul 1. doi: 10.1097/PEC.0000000000001865. PMID:31274824

    39

    Charles Apprey, Christopher Larbie, Reginald A. Annan , Fareed K. N. Arthur , Samira Abdulai-Saiku , Doris Berkoh and Alex Osei-Akoto. Effects of chemotherapy and disease burden on the nutritional status of patients undergoing treatment for burkitt’s lymphoma. Der Pharmacia Lettre, 2015, 7 (2):95-99)

    40

    Charles Apprey, Reginald A. Annan, Fareed K. N. Arthur, Christopher Larbie and Alex O. Akoto. Nutritional Intervention in Children Undergoing Chemotherapy for Cancer. Journal of Cancer and Tumor International 7(4): 1-11, 2018; Article no.JCTI.43197 ISSN: 2454-7360

    41

    Kwabena Nsiah, Alex Osei-Akoto, Daniel Ansong. The Drug Regimen Prescribed for Sickle Cell Patients Attending a Clinic in Kumasi, Ghana, in a Period of One Year: Open Journal of Blood Diseases, 2014, 4, 50-57 Published Online December 2014 in SciRes

    42

    Kwabena Nsiah, Victoria P. Dzogbefia, Daniel Ansong, Alex Osei-Akoto The Diagnostic Implications of Spot Urinalysis of Subjects from a Ghanaian Sickle Cell Clinic. Journal of Internal Medicine Research JIMR 2014, 2(2):15-20 10.12966/jimr.09.01.2014

    43

    D Ansong, J A Osei, S K Owusu, I Nyanor, J Bonney, , A Enimil,  D O Laryea, J Dapaah, P Agei-Baffour, N Mensah, I Osei-Peprah, A Owusu, E Addo-Yobo, A Osei-Akoto,  O A Owusu, SCY Appiah, V Ampiah, J O Saahene, E X Amuzu,  M Telly, J Sylverken. Educating caregivers to recognise the clinical signs of pneumonia in children younger than 6 months. July 2020. South African Journal Of Child Health 14(2):71 DOI: 10.7196/SAJCH.2020.v14i2.1642


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