Dr. (Mrs.) Linda Batsa Debrah

Senior Lecturer

Dept: Clinical Microbiology
KCCR/KNUST
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Research Areas/Interests

Molecular /genetic identification of biomarkers for diagnosis of infectious diseases Clinical trials to assess drug efficacy in Neglected Tropical Di...~more

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Publications

    Journal articles

     

    1. Horton J, Klarmann-Schulz U, Stephens M, Budge PJ, Coulibaly Y, Debrah  A, Debrah LB, Krishnasastry S,Mwingira U, Ngenya A,Wanji S, Weerasooriya  M, Yahathugoda C, Kroidl I, Deathe D, Majewski A, Sullivan S, Mackenzie C, Nutman TB, Shott JP, Weil G, Ottesen E and Hoerauf A. (2020) The design and development of a multicentric protocol to investigate the impact of adjunctive doxycycline on the management of peripheral lymphoedema caused by lymphatic filariasis and podoconiosis. Parasit Vectors 13(1),1-11. doi:10.1186/s13071-020-04024-2 .
    2. Debrah LB, Klarmann-Schulz U, Osei-Mensah J, Dubben B, Fischer K, Mubarik Y, Ayisi-Boateng NK, Ricchiuto A, Fimmers R, Konadu P, Nadal J, Gruetzmacher B, Weil G, Kazura JW, King CL, Debrah AY, Hoerauf A. (2019) Comparison of repeated doses of ivermectin versus ivermectin plus albendazole for treatment of onchocerciasis - a randomized open-label clinical trial. Clin Infect Dis. 2019 Sep 19. pii: ciz889. doi: 10.1093/cid/ciz889.
    3. Debrah LB, Phillips RO, Pfarr K, Klarmann-Schulz U, Opoku VS, Nausch N, Owusu W, Mubarik Y, Sander AL, Lämmer C, Ritter M, Layland LE, Jacobsen M, DebrahAY, Hoerauf A. (2019) The Efficacy of Doxycycline Treatment on Mansonella perstans Infection: An Open-Label, Randomized Trial in Ghana. Am J Trop Med Hyg. 2019 Jun 3. doi: 10.4269/ajtmh.18-0491. PubMed PMID: 31162017.
    4. Nausch N, Antwi-Berko D, Mubarik Y, Abass KM, Owusu W, Owusu-Dabo E, Debrah LB, Debrah AY, Jacobsen M, Phillips RO (2017). Analysis of Mycobacterium ulcerans-specific T-cell cytokines for diagnosis of Buruli ulcer disease and as potential indicator for disease progression. PLoS Negl Trop Dis. 2017 Feb 27;11(2):e0005415. doi: 10.1371/journal.pntd.0005415. eCollection 2017 Feb.
    5. Lagatie O, Batsa Debrah L, Debrah A, Stuyver LJ.(2017) Plasma-derived parasitic microRNAs have insufficient concentrations to be used as diagnostic biomarker for detection of Onchocerca volvulus infection or treatment monitoring using LNA-based RT-qPCR Parasitol Res. 2017 Mar;116(3):1013-1022. doi: 10.1007/s00436-017-5382-5. Epub 2017 Jan 22. PMID:28111713
    6. Debrah LB, Nausch N, Opoku VS, Owusu W, Mubarik Y, Berko DA, Wanji S, Layland LE, Hoerauf A, Jacobsen M, Debrah AY, Phillips RO (2017). Epidemiology of Mansonella perstans in the middle belt of Ghana. Parasit Vectors. 2017 Jan 7;10(1):15. doi: 10.1186/s13071-016-1960-0.PMID:28061905
    7. Nausch N, Berko DA, Mubarik y, Abass KM, Owusu W, Owusu-Dabo E, Debrah LB,, Debrah AY, Jacobsen M, Phillips RO (2017) Analysis of Mycobacterium ulcerans-specific Tcell cytokines for diagnosis of Buruli ulcer disease and as potential indicator for disease progression. PLoS Negl Trop Dis 11(2): e0005415. doi:10.1371/journal.pntd.0005415
    8. Lagatie O, Merino M,Debrah LB, Debrah AY, Stuyver LJ. (2016) An isothermal DNA amplification method for detection of Onchocerca volvulus infection in skin biopsies. Parasit Vectors. 1;9 (1):624.PMID:27906100
    9. Stanton MC, Best A, Cliffe M, Kelly-Hope L, Biritwum NK, Batsa L, Debrah A. Situational analysis of lymphatic filariasis morbidity in Ahanta West District of Ghana. (2016) Trop Med Int Health. 21(2): 236-44. doi: 10.1111/tmi.12643. Epub 2015 Dec 18.PMID: 26584839
    10. Stanton MC, Mkwanda SZ, Debrah AY, Batsa L, Biritwum NK, Hoerauf A, Cliffe M, Best A, Molineux A, Kelly-Hope LA. Developing a community-led SMS reporting tool for the rapid assessment of lymphatic filariasis morbidity burden: case studies from Malawiand Ghana. (2015) BMC Infect Dis. 2015 May 16; 15:214. doi: 10.1186/s12879-015-0946-4. PMID: 25981497
    11. Debrah AY, Specht S, Klarmann-Schulz U, Batsa L, Mand S, Marfo-Debrekyei Y, Fimmers R, Dubben B, Kwarteng A, Osei-Atweneboana M, Boakye D, Ricchiuto A, Büttner M, Adjei O, Mackenzie CD, Hoerauf A. (2015). Doxycycline Leads to Sterility and Enhanced Killing of Female Onchocerca volvulus Worms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial. Clin Infect Dis. 61(4):517-26. doi: 10.1093/cid/civ363. Epub 2015 May 6. PMID: 25948064
    12. Arndts K, Klarmann-Schulz U, Batsa L, Debrah AY, Epp C, Fimmers R, Specht S, Layland LE, Hoerauf A. (2015). Reductions in microfilaridermia by repeated ivermectin treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulus-infected individuals. Parasit Vectors. 8:184. doi: 10.1186/s13071-015-0786-5. PMID: 25889652
    13. Ritter, M., Osei-Mensah, J., Debrah, L.B., Kwarteng, A., Mubarik, Y., Debrah, A.Y., Pfarr, K., Hoerauf, A. and Layland, L.E., (2019). Wuchereria bancrofti-infected individuals harbor distinct IL-10-producing regulatory B and T cell subsets which are affected by anti-filarial treatment. PLoS Negl Trop Dis, 13(5), p.e0007436
    14. Lagatie O, Verheyen A, Nijs E, Debrah L.B, Debrah YA, Stuyver LJ (2019) Performance evaluation of 3 serodiagnostic peptide epitopes and the derived multi-epitope peptide OvNMP-48 for detection of Onchocerca volvulus infection. Parasitol Res. 2019 May 14. doi: 10.1007/s00436-019-06345-3.
    15. Lagatie O, Verheyen A, Van Dorst B, Batsa Debrah L, Debrah A, Stuyver LJ. (2018). Linear epitopes in Onchocerca volvulus vaccine candidate proteins and excretory-secretory proteins. Parasite Immunol. 40(11):e12587.
    16. Debrah LB, Albers A, Debrah AY, Brockschmidt FF, Becker T, Herold C, Hofmann A, Osei-Mensah J, Mubarik Y, Fröhlich H, Hoerauf A, Pfarr K (2017). Single nucleotide polymorphisms in the angiogenic and lymphangiogenic pathways are associated with lymphedema caused by Wuchereria bancrofti. Hum Genomics. 11(1):26. doi: 10.1186/s40246-017-0121-7.
    17. Debrah LB, Nausch N, Opoku VS, Owusu W, Mubarik Y, Berko DA, Wanji S, Layland LE, Hoerauf A, Jacobsen M, Debrah AY, Phillips RO (2017) Epidemiology of Mansonella perstans in the middle belt of Ghana.Parasit Vectors.7;10 (1):15. doi: 10.1186/s13071-016-1960-0.
    18. Lagatie O, Debrah LB, Debrah A, Stuyver LJ (2017) Plasma-derived parasitic microRNAs have insufficient concentrations to be used as diagnostic biomarker for detection of Onchocerca volvulus infection or treatment monitoring using LNA-based RT-qPCR. Parasitol Res. doi: 10.1007/s00436-017-5382-5.
    19. Klarmann-Schulz U, Specht S, Debrah AY, Batsa L, Ayisi-Boateng NK, Osei-Mensah J, Mubarik Y, Konadu P, Ricchiuto A, Fimmers R, Arriens S, Dubben B, Ford L, Taylor M, Hoerauf A (2017) Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial. (2017) PLoS Negl Trop Dis. 5;11(1):e0005156. doi: 10.1371/journal.pntd.0005156.
    20. Lagatie O, Ediage EN, Debrah LB, Diels L, Nolten C, Vinken P, Debrah A, Dillen L, Silber S, Stuyver LJ. (2016) Evaluation of the diagnostic potential of urinary N-Acetyltyramine-O,β-glucuronide (NATOG) as diagnostic biomarker for Onchocerca volvulus infection. Parasit Vectors. 23;9(1):302. doi: 10.1186/s13071-016-1582-6
    21. Katawa G, Layland LE, Debrah AY, von Horn C, Batsa L, Kwarteng A., Arriens, S., Taylor DW, Specht S, Achim Hoerauf A, Tomabu Adjobimey T (2015). Hyperreactive Onchocerciasis is Characterized by a Combination of Th17-Th2 Immune Responses and Reduced Regulatory T Cells. PLoS Negl Trop Dis 9(1): e3414. doi:10.1371.
    22.  Klarmann-Schulz U, Arndts K, Batsa L, Debrah A, Epp C, Fimmers R, Specht S, Layland RE, Hoerauf A. (2015). Ivermectin treatment is crucial for Plasmodium-specific Th17 mmune responses in Onchocerca volvulus-infected individuals. Parasit Vectors doi: 10.1186/s13071-015-0786-5
    23. Mand S, Debrah AY, Klarmann U, Batsa L, Marfo-Debrekyei Y, Kwarteng A, Specht S, Belda-Domene A, Fimmers R, Taylor M, Adjei O, Hoerauf A (2012). Doxycycline Improves Filarial Lymphedema Independent of Active Filarial Infection: A Randomized Controlled Trial. Clin Infect Dis. PMID: 22610930
    24. Arndts K, Deininger S, Specht S, Klarmann U, Mand S, Adjobimey T, Debrah AY, Batsa L, Kwarteng A, Epp C, Taylor M, Adjei O, Layland LE, Hoerauf A. (2012). Elevated Adaptive Immune Responses Are Associated with Latent Infections of Wuchereria bancrofti. PLoS Negl Trop Dis. 6(4): e1611. doi: 10.1371.
    25. Debrah AY, Batsa L, Albers A, Mand S, Toliat MR, Nürnberg P, Adjei O, Hoerauf A, and Pfarr K. (2011). Transforming Growth Factor-β 1 variant Leu10Pro is associated with both lack of Microfilariae and differential Microfilarial loads in the blood of people infected with lymphatic filariasis. Hum Immunol 72:1143-8
    26. Debrah, A.Y., Mand, S., Marfo-Debrekyei, Y., Batsa, L., Albers, A., Specht, S., Klarmann, U., Pfarr, K., Adjei, O., and Hoerauf, A. (2011). Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline. J Parasitol Res 17:977-85.
    27. Mand S, Debrah AY, Klarmann U, Mante S, Kwarteng A, Batsa L, Marfo-Debrekyei Y, Adjei O, Hoerauf A (2010). The role of ultrasonography in the differentiation of the various types of filaricele due to bancroftian filariasis. Acta Trop. 20 Suppl 1:S23-32
    28. Debrah AY, Mand S, Marfo-Debrekyei Y, Batsa L, Pfarr K, Lawson B, Taylor M, Adjei O, Hoerauf A (2009). Reduction in levels of plasma vascular endothelial growth factor-A and improvement in hydrocele patients by targeting endosymbiotic Wolbachia sp. in Wuchereria bancrofti with doxycycline. Am J Trop Med Hyg. 80:956-963.
    29. Hoerauf A, Specht S, Marfo-Debrekyei Y, Büttner M, Debrah AY, Mand S, Batsa L, Brattig N, Konadu P, Bandi C, Fimmers R, Adjei O, Büttner DW. (2009) Efficacy of 5-week doxycycline treatment on adult Onchocerca volvulus. Parasitol Res.104(2):437-47. doi: 10.1007/s00436-008-1217-8. Epub 2008 Oct 11.PMID:18850111
    30. Debrah AY, Mand S, Marfo-Debrekyei Y, Batsa L, Pfarr K, Buttner M, Adjei O, Buttner D, Hoerauf A (2007). Macrofilaricidal effect of 4 weeks of treatment with doxycycline on Wuchereria bancrofti. Trop Med Int Health. 12(12):1433-41.PMID:18076549
    31. Hoerauf A, Specht S, Büttner M, Pfarr K, Mand S, Fimmers R, Marfo-Debrekyei Y, Konadu P, Debrah AY, Bandi B, Brattig N, Albers A, Larbi J, Batsa L, Adjei O, Büttner DW. (2007). Wolbachia endobacteria depletion by doxycycline as antifilarial therapy is macrofilaridical in onchocerciasis. Med Microbiol Immunol 196:10.1007/s00430-00007-00062-00431
    32. Debrah AY, Mand S, Toliat MR, Marfo-Debrekyei Y, Batsa L, Nürnberg P, Lawson B, Adjei O, Hoerauf A, Pfarr K. (2007). Plasma vascular endothelial growth factor-A (VEGF-A) and VEGF-A gene polymorphism are associated with hydrocele development in lymphatic filariasis. Am J Trop Med Hyg 77: 601-608
    33. Debrah AY, Mand S, Specht S, Marfo-Debrekyei Y, Batsa L, Pfarr K, Larbi J, Lawson B, Taylor M, Adjei O, Hoerauf A. (2006). Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis. PLoS Pathog. 2(9):e92.PMID:17044733
    34. Mand S, Marfo-Debrekyei Y, Debrah A, Buettner M, Batsa L, Pfarr K, Adjei O, Hoerauf (2005). Frequent detection of worm movements in onchocercal nodules by ultrasonography. A Filaria J. 23;4(1):1 PMID:15788103
    35. Mand S, Debrah A, Batsa L, Adjei O, Hoerauf A. (2004). Reliable and frequent detection of adult Wuchereria bancrofti in Ghanaian women by ultrasonography. Trop Med Int Health. 9(10): 1111-4. PMID: 15482404
    36. Arndts K, Specht S, Debrah AY, Tamarozzi F, Klarmann Schulz U, Mand S, Batsa L, Kwarteng A, Taylor M, Adjei O, Martin C, Layland LE, Hoerauf A. (2014) Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels.PLoS Negl Trop Dis. 2014 Feb 20;8(2):e2679. doi: 10.1371

     

    ABSTRACTS PRESENTATION AT CONFERENCES

    1. Kroidl I, Feichtner A, Horn S, Mwingira U, Ngenya A, Chotta G, Klarmann-Schulz U, Kuehlwein J, Hoerauf A, Osei-Mensah J, Debrah LB, Debrah AY (2019). Immune activation in patients with filarial lymphedema before and after treatment with doxycycline. 68th Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), National Harbor, MA, USA, November 2019 (Poster presentation- Abstract No. 528).

    2. Debrah LB, Osei-Mensah J, Mubarik Y, Mohammed A, Agbenyega O, Ayisi-Boateng NK, Kuehlwein JM, Klarmann-Schulz U, Hoerauf A, Debrah AY (2019). Lymphatic filariasis pathology and acute Dermatolymphangioadenitis (ADLA) attacks using a mobile phone-based tool by community health volunteers in Ghana. 68th Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), National Harbor, MA, USA, November 2019 (Oral presentation- Abstract No. 1283).

    • Gyamfi PA, Debrah AY, Osei-Mensah J, Opoku SV,  Adu-Mensah D, Mubarik Y, Horeauf A, Debrah LB (2019). Impact of 15 Years of Mass Drug Administration on Lymphatic Filariasis Control Efforts in the Kassena Nankana East Municipal. The 8th College of Health Sciences and 12th Convention of Biomedical Research Kumasi, Ghana, July 2019 (Oral presentation- Abstract No. 4). 

    1. Debrah LB, Specht S, Klarmann-Schulz U, Debrah AY, Osei-Mensah J, Dubben B, Mand S, Mubarik Y, Ricchiuto A, Fimmers R, Johnston K, Taylor M, Hoerauf A (2017). Doxycycline for the treatment of onchocerciasis: A daily dose of 100 mg for 6 weeks shows Reduction of fertile female onchocerca volvulus Worms equivalent to 200 mg/d. 66th Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, November 2017 (Oral presentation- Abstract No. 531).

    2. Mubarik Y, Debrah LB, Osei-Mensah J, 1, Fordjour FA, Debrah AY (2019). Microfilaridermia Assessment of the Efficacy of Ivermectin Alone and Ivermectin
      Plus Albendazole against Onchocerciasis. The 8th College of Health Sciences and 12th Convention of Biomedical Research Kumasi, Ghana, July 2019 (Poster presentation- Abstract No. P012). 

    3. Fordjour FA, Debrah LB, Osei-Mensah J, Mubarik Y, Gyamfi PA, Debrah AY (2019). Assessing the Involvement of Nuclear Kappa Light Chain Enhancer of Activated B cell Inhibitor-Alpha in Filarial Lymphedema Development. The 8th College of Health Sciences and 12th Convention of Biomedical Research Kumasi, Ghana, July 2019 (Oral presentation- Abstract No. 14). 

    4. Klarmann-Schulz U, Debrah LB, Osei-Mensah J, Dubben B, Fischer K, Mubarik Y, Ricchiuto A, Fimmers R, Weil GJ, Kazura JW, King CL, Debrah AY, Hoerauf A (2017). The addition of albendazole to ivermectin does not reduce female worm fertility in onchocerciasis. 66th Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, November 2017 (Oral presentation- Abstract No. 533).

    5. Nausch N, Antwi-Berko D, Mubarik Y, Kabiru MA, Owusu W, Owusu-Dabo E, Debrah LB, Debrah AY,Jacobsen M, Phillips RO (2017). Biomarkers and immune modulation in Buruli Ulcer disease. 66th Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, November 2017 (Oral presentation- Abstract No. 752).

    6. Lagatie O, Verheyen A, Nijs N, Van Dorst B, Debrah LB, Debrah A, Stuyver, LJ   (2016). Immunoreactivity of an Onchocerca volvulus linear epitope in individuals from different Regions in Ghana. 65th Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, November 2016 (Oral presentation- Abstract No. 496).

    7. Osei-Mensah J, Ritter M, Debrah LB, Albers A, Mubarik Y, Layland L, Pfarr K, Hoerauf A, Debrah A  (2016). Toll-like receptor 2 expression on immune cells is elevated in cured asymptomatic individuals in lymphatic filariasis. 65th Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, October 2016 (Oral presentation- Abstract No. 598).
    8. Osei-Mensah J, Debrah LB, Albers A, Lust L, Brockschmidt F, Becker T, Herold C, Mubarik Y, Fröhlich H, Pfarr K, Hoerauf A and Debrah A. Single nucleotide polymorphisms in angiogenic and inflammation pathway genes predispose infected hosts to having patent or latent lymphatic filariasis. 64th Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, October 2015 (Poster presentation- Abstract No. 1708).
    9. Weier C, Albers A, Debrah LB, Mante S, Mand S, Stoffel-Wagner B, Klarmann-Schulz U, Debrah A, Pfarr K, Hoerauf A. Mediators of vascular permeability and lymph/angiogenesis are markers for hydroceles caused by Wuchereria bancrofti infection. 64th Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, October 2015 (Oral presentation- Abstract No. 1709).

    10. Klarmann-Schulz U, Batsa L, Specht S, Debrah AY, Osei-Mensah J, Ayisi-Boateng NK, Mubarik Y, Ford L, Konadu P, Mark J. Taylor MJ, Achim Hoerauf. Comparison of doxycycline, minocycline, doxycycline plus albendazole and albendazole alone in their efficacy against onchocerciasis. 64th Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, October 2015 (Oral presentation- Abstract No. 639).

    11. Debrah AY, Sabine Specht, Linda Batsa, Ute Klarmann, Sabine Mand, Alexander Kwarteng, Mike Osei-Atweneboana,Daniel Boakye, Ohene Adjei and Achim Hoerauf. Doxycycline treatment shows a strong embryostatic effect and clearance of persistent microfilariae in the skin of onchocerciasis patients in whom repeated ivermectin treatment had failed to clear microfilaridermia. 63rd Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), New Orleans, USA, November 2014 (Oral presentation- Abstract No. 1207).

    12. Debrah AY, Sabine Mand, Henry Atawurah, Nana K. Ayisi-Boateng, Linda Batsa, Alexander Kwarteng, Jubin Osei-Mensah, Yusif Mubarik, Sabine Specht, Arcangelo Ricchiuto, Rolf Fimmers, Achim Hoerauf, Ute Klarmann-Schulz. Long-term improvement of hydrocele size after ultrasound-guided aspiration. 63rd Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), New Orleans, USA, November 2014 (Oral presentation- Abstract No. 1210).

    13. Michelle C. Stanton, Square Z. Mkwanda, Debrah AY, Linda B. Debrah, Achim Hoerauf, Nana-KwadwoBiritwum, Abigail Best, Matthew Cliffe, Louise A. Kelly-Hope. Utilizing the community health worker network for lymphatic filariasis (LF) morbidity monitoring: the development of an SMS-based surveillance tool. 63rd Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), New Orleans, USA, November 2014 (Poster presentation- Abstract No. 1689).

    14. Torres M, Pilotte N, Adjobimey T, Specht S, Terry F, Debrah A, Batsa L, Kwarteng A, de Groot A, Williams S, Hoerauf A. Evaluation of HLA Immunoinformatics for the identification of Brugia malayi putative T cellepitopes conserved with Wuchereria bancrofti andLloa loa. 63rd Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), New Orleans, USA, November 2014 (Poster presentation- Abstract No. 1713).

    15. Batsa L, Debrah AY, Albers A, Mensah J, Brockschmidt F, Becker T, Herold C, Fröhlich H, Lust L, Mand S, Klarmann-Schulz U, Hoerauf A and Pfarr KM. VEGFR3 and other angiogennic/lymphangiogenic genes are associated with development of lymphedema of filarial origin. 62nd Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Washington, USA, November 2013 (Poster presentation- Abstract No.1187).
    16. Linda Batsa, Anna Albers, Jubin Mensah, Felix F. Brockschmidt, Tim Becker, Christine Herold, Holger Fröhlich, Lydia Lust, Sabine Mand, Ute Klarmann-Schulz, Achim Hoerauf and Kenneth M. Pfarr, Debrah A. VEGF-R3 and other angiogennic/lymphangiogenic genes are associated with development of lymphedema of filarial origin.  6th Annual meeting of Ghana Biomedical Convention, Cape Coast, Ghana, July 2013 (Oral presentation- Abstract No.36).

    17. Klarmann U, Debrah AY, Mand, S Linda Batsa, Sabine Specht, Kenneth Pfarr, Alexander Kwarteng, Rolf Fimmers, Mark Taylor, Ohene Adjei, Achim Hoerauf. Shortening the timeframe and dosage of anti-Wolbachia therapy: doxycycline alone versus doxycycline plus rifampicin in their efficacy against lymphatic filariasis; a randomized, double-blind, placebo-controlled trial. 61st Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, November 2012 (Oral presentation- Abstract No.522).

    18. Albers A, Batsa L, Lust L, Mensah J, Brockschmidt F, Becker T, Herold C, Klarmann U, Debrah AY, Hoerauf A, Pfarr K. Genes of the angiogenesis pathway are associated with development of hydrocele in lymphaticfilariasis - a candidate-gene analysis. 61nd Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, November 2012 (Oral presentation- Abstract No.519).

    19. Debrah AY, Batsa L., Albers A., Mand, S., Toliat, M.R., Nürnberg, P., Adjei, O., Hoerauf, A., and Pfarr, K. (2011). Transforming Growth Factor-β 1 variant Leu10Pro is associated with both lack of Microfilariae and differential Microfilarial loads in the blood of people infected with lymphatic filariasis. 1st International Society for Infectious Diseases-Neglected Tropical Diseases Meeting in Boston, Massachusetts, USA. July 2011 (Oral presentation- Abstract No. 07.011).

    20. Debrah AY, Specht S, Mand M, Batsa L, Klarmann U, Marfo-Debrekyei Y, Kwarteng A, Osei-Atweneboana M,Boakye D, Adjei O, Hoerauf A. (2010) Targeting Wolbachia endosymbionts in Onchocerca volvulus effectively clears persistent microfilariae in the skin of onchocerciasis patients in whom repeated ivermectin treatment had failed to clear. 59th Annual Meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, November 2010 (Oral presentation- Abstract No. 1331).

    21. Hoerauf A, Klarmann U, Debrah AY, Batsa L, Adjei O, Mand S. The sensitivity of standard circulating filarial antigen tests and ultrasonography for individual diagnostics and epidemiological surveillance of bancroftian filariasis. 59th Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, November 2010 (Oral presentation- Abstract No.1328)

    22. Debrah AY, Mand S, Toliat MR, Marfo-Debrekyei Y, Batsa L, Nuernberg P, Bernard Lawson, Adjei O, HoeraufA, Pfarr K. Targeting endosymbiotic Wolbachia in Wuchereria bancrofti reduces plasma VEGF with amelioration of condition of hydrocele patients. International Congress on Parasitology XII (ICOPA XII) in Melbourne, Australia, August 2010 (Oral Presentation and co-Chairman of one of the symposia- Abstract no. 323). 

    23. Debrah AY, Specht S, Mand M, Batsa L, Klarmann U, Marfo-Debrekyei Y, Kwarteng A, Osei-Atweneboana M,Boakye D, Adjei O, Hoerauf A. Targeting Wolbachia endosymbionts in Onchocerca volvulus effectively clears persistent microfilariae in the skin of onchocerciasis patients in whom repeated ivermectin treatment had failed to clear. Biannual Meeting of Royal Society of Tropical Medicine and Hygiene (RSTMH), Liverpool, UK, October 2010 (Poster presentation- Abstract No. P.04).

    24. Batsa L, Specht S, Debrah AY, Mand M, Klarmann U, Marfo-Debrekyei Y, Kwarteng A, Osei-Atweneboana M,Boakye D, Adjei O, Hoerauf A. Targeting Wolbachia endosymbionts in Onchocerca volvulus effectively clears persistent microfilariae in the skin of onchocerciasis patients in whom repeated ivermectin treatment had failed to clear. 6th International Wolbachia Conference. San Francisco, USA. June 2010 (Oral presentation- Abstract No. 7-11).

    25. Mand S, Debrah AY, Specht S, Kwarteng A, Klarmann U, Fimmers R, Batsa L, Marfo-Debrekyei Y, Adjei O, Hoerauf A. Doxycycline improves filarial lymphoedema independent of its action on Wolbachia. 58th Annual Meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Washington, USA, November 2009 (Oral presentation- Abstract No. 1102).

    26. Adjei O, Debrah AY, Mand M, Specht S, Batsa L, Marfo-Debrekyei Y, Pfarr K, Hoerauf A. Macrofilaricidal activity of doxycycline in human onchocerciasis in Ghana. 2nd  Annual Scientific Conference of College of Health Sciences of Kwame Nkrumah University of Science Technology, Kumasi, Ghana. November 2009 (Oral presentation- Abstract No. F39).

    27. Debrah AY, Mand S, Toliat MR, Marfo-Debrekyei Y, Batsa L, Nuernberg P, Bernard Lawson, Adjei O, HoeraufA, Pfarr K. Targeting endosymbiotic Wolbachia in Wuchereria bancrofti reduces plasma VEGF-A and improves condition of hydrocele patients. 5th International Wolbachia Meeting in Crete, Greece, June, 2008 (Oral Presentation Abstract no. F2). 

    28. Debrah AY, Mand S, Marfo-Debrekyei Y, Batsa L, Adjei O, Pfarr K, Hoerauf A. Onchocerciasis control: Vision for the Future- Antibiotic therapy: Progress from the field - onchocerciasis. A workshop organized by the Royal Society of Tropical Medicine and Hygiene at Elmina, Ghana April 2008. (Oral presentation).

    29. Debrah AY, Mand S, Toliat MR, Marfo-Debrekyei Y, Batsa L, Nuernberg P, Bernard Lawson, Adjei O, HoeraufA, Pfarr K. Targeting endosymbiotic Wolbachia in Wuchereria bancrofti reduces plasma VEGF-A and improves condition of hydrocele patients. 56th Annual Meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Philadelphia, USA, November 2007 (Oral presentation and won Travel award for this meeting- Abstract No. 388).

    30. Hoerauf A, Specht S, Buttner M, Pfarr K, Mand S, Filmmers R, Konadu P, Debrah AY, Bandi C, Brattig NW, Albers A, Batsa L, Adjei O, Buettner D. Wolbachia endobacteria depletion by doxycycline as antifilarial therapy is macrofilaricidal  in onchocerciasis. 56th Annual Meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Philadelphia, USA, November 2007 (Oral presentation - Abstract No. 389).

    31. Debrah AY, Mand S, Marfo-Debrekyei Y, Batsa L, Pfarr K, Adjei O, Hoerauf A. Effect of targeting endosymbiotic Wolbachia in Wuchereria bancrofti on pathology of filariasis infection. 4th International Wolbachia Meeting in Puerto Rico, Caribbean, June 2006 (Oral Presentation Abstract no A-1).

    32. Debrah AY, Sabine Mand S, Marfo-Debrekyei Y, Batsa L, Pfarr K, Adjei O, Hoerauf A. Evaluation of endosymbiotic Wolbachia DNA in blood as a potential tool for diagnosis of lymphatic filariasis infection. 4thInternational Wolbachia Meeting in Puerto Rico, Caribbean, June 2006 (Oral Presentation Abstract no A-2).

    33. Debrah AY, Sabine Mand S, Marfo-Debrekyei Y, Batsa L, Pfarr K, Adjei O, Hoerauf A. Effect of targeting Endosymbiotic Wolbachia in Wuchereria bancroftian on macrofilaricidal effect, over-expression of VEGF-C/VEGFR-3 and lymphatic dilation in lymphatic filariasis-Results from a 6 weeks trial with doxycycline 22ndGerman Parasitologists Conference in Vienna, Austria. April 2006 (Oral Presentation Abstract no. 23).
    34.  

    Journal articles

     

    1. Horton J, Klarmann-Schulz U, Stephens M, Budge PJ, Coulibaly Y, Debrah  A, Debrah LB, Krishnasastry S,Mwingira U, Ngenya A,Wanji S, Weerasooriya  M, Yahathugoda C, Kroidl I, Deathe D, Majewski A, Sullivan S, Mackenzie C, Nutman TB, Shott JP, Weil G, Ottesen E and Hoerauf A. (2020) The design and development of a multicentric protocol to investigate the impact of adjunctive doxycycline on the management of peripheral lymphoedema caused by lymphatic filariasis and podoconiosis. Parasit Vectors 13(1),1-11. doi:10.1186/s13071-020-04024-2 .
    2. Debrah LB, Klarmann-Schulz U, Osei-Mensah J, Dubben B, Fischer K, Mubarik Y, Ayisi-Boateng NK, Ricchiuto A, Fimmers R, Konadu P, Nadal J, Gruetzmacher B, Weil G, Kazura JW, King CL, Debrah AY, Hoerauf A. (2019) Comparison of repeated doses of ivermectin versus ivermectin plus albendazole for treatment of onchocerciasis - a randomized open-label clinical trial. Clin Infect Dis. 2019 Sep 19. pii: ciz889. doi: 10.1093/cid/ciz889.
    3. Debrah LB, Phillips RO, Pfarr K, Klarmann-Schulz U, Opoku VS, Nausch N, Owusu W, Mubarik Y, Sander AL, Lämmer C, Ritter M, Layland LE, Jacobsen M, DebrahAY, Hoerauf A. (2019) The Efficacy of Doxycycline Treatment on Mansonella perstans Infection: An Open-Label, Randomized Trial in Ghana. Am J Trop Med Hyg. 2019 Jun 3. doi: 10.4269/ajtmh.18-0491. PubMed PMID: 31162017.
    4. Nausch N, Antwi-Berko D, Mubarik Y, Abass KM, Owusu W, Owusu-Dabo E, Debrah LB, Debrah AY, Jacobsen M, Phillips RO (2017). Analysis of Mycobacterium ulcerans-specific T-cell cytokines for diagnosis of Buruli ulcer disease and as potential indicator for disease progression. PLoS Negl Trop Dis. 2017 Feb 27;11(2):e0005415. doi: 10.1371/journal.pntd.0005415. eCollection 2017 Feb.
    5. .Lagatie O, Batsa Debrah L, Debrah A, Stuyver LJ.(2017) Plasma-derived parasitic microRNAs have insufficient concentrations to be used as diagnostic biomarker for detection of Onchocerca volvulus infection or treatment monitoring using LNA-based RT-qPCR Parasitol Res. 2017 Mar;116(3):1013-1022. doi: 10.1007/s00436-017-5382-5. Epub 2017 Jan 22. PMID:28111713
    6. Debrah LB, Nausch N, Opoku VS, Owusu W, Mubarik Y, Berko DA, Wanji S, Layland LE, Hoerauf A, Jacobsen M, Debrah AY, Phillips RO (2017). Epidemiology of Mansonella perstans in the middle belt of Ghana. Parasit Vectors. 2017 Jan 7;10(1):15. doi: 10.1186/s13071-016-1960-0.PMID:28061905
    7. Nausch N, Berko DA, Mubarik y, Abass KM, Owusu W, Owusu-Dabo E, Debrah LB,, Debrah AY, Jacobsen M, Phillips RO (2017) Analysis of Mycobacterium ulcerans-specific Tcell cytokines for diagnosis of Buruli ulcer disease and as potential indicator for disease progression. PLoS Negl Trop Dis 11(2): e0005415. doi:10.1371/journal.pntd.0005415
    8. Lagatie O, Merino M,Debrah LB, Debrah AY, Stuyver LJ. (2016) An isothermal DNA amplification method for detection of Onchocerca volvulus infection in skin biopsies. Parasit Vectors. 1;9 (1):624.PMID:27906100
    9. Stanton MC, Best A, Cliffe M, Kelly-Hope L, Biritwum NK, Batsa L, Debrah A. Situational analysis of lymphatic filariasis morbidity in Ahanta West District of Ghana. (2016) Trop Med Int Health. 21(2): 236-44. doi: 10.1111/tmi.12643. Epub 2015 Dec 18.PMID: 26584839
    10. Stanton MC, Mkwanda SZ, Debrah AY, Batsa L, Biritwum NK, Hoerauf A, Cliffe M, Best A, Molineux A, Kelly-Hope LA. Developing a community-led SMS reporting tool for the rapid assessment of lymphatic filariasis morbidity burden: case studies from Malawiand Ghana. (2015) BMC Infect Dis. 2015 May 16; 15:214. doi: 10.1186/s12879-015-0946-4. PMID: 25981497
    11. Debrah AY, Specht S, Klarmann-Schulz U, Batsa L, Mand S, Marfo-Debrekyei Y, Fimmers R, Dubben B, Kwarteng A, Osei-Atweneboana M, Boakye D, Ricchiuto A, Büttner M, Adjei O, Mackenzie CD, Hoerauf A. (2015). Doxycycline Leads to Sterility and Enhanced Killing of Female Onchocerca volvulus Worms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial. Clin Infect Dis. 61(4):517-26. doi: 10.1093/cid/civ363. Epub 2015 May 6. PMID: 25948064
    12. Arndts K, Klarmann-Schulz U, Batsa L, Debrah AY, Epp C, Fimmers R, Specht S, Layland LE, Hoerauf A. (2015). Reductions in microfilaridermia by repeated ivermectin treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulus-infected individuals. Parasit Vectors. 8:184. doi: 10.1186/s13071-015-0786-5. PMID: 25889652
    13. Ritter, M., Osei-Mensah, J., Debrah, L.B., Kwarteng, A., Mubarik, Y., Debrah, A.Y., Pfarr, K., Hoerauf, A. and Layland, L.E., (2019). Wuchereria bancrofti-infected individuals harbor distinct IL-10-producing regulatory B and T cell subsets which are affected by anti-filarial treatment. PLoS Negl Trop Dis, 13(5), p.e0007436
    14. Lagatie O, Verheyen A, Nijs E, Debrah L.B, Debrah YA, Stuyver LJ (2019) Performance evaluation of 3 serodiagnostic peptide epitopes and the derived multi-epitope peptide OvNMP-48 for detection of Onchocerca volvulus infection. Parasitol Res. 2019 May 14. doi: 10.1007/s00436-019-06345-3.
    15. Lagatie O, Verheyen A, Van Dorst B, Batsa Debrah L, Debrah A, Stuyver LJ. (2018). Linear epitopes in Onchocerca volvulus vaccine candidate proteins and excretory-secretory proteins. Parasite Immunol. 40(11):e12587.
    16. Debrah LB, Albers A, Debrah AY, Brockschmidt FF, Becker T, Herold C, Hofmann A, Osei-Mensah J, Mubarik Y, Fröhlich H, Hoerauf A, Pfarr K (2017). Single nucleotide polymorphisms in the angiogenic and lymphangiogenic pathways are associated with lymphedema caused by Wuchereria bancrofti. Hum Genomics. 11(1):26. doi: 10.1186/s40246-017-0121-7.
    17. Debrah LB, Nausch N, Opoku VS, Owusu W, Mubarik Y, Berko DA, Wanji S, Layland LE, Hoerauf A, Jacobsen M, Debrah AY, Phillips RO (2017) Epidemiology of Mansonella perstans in the middle belt of Ghana.Parasit Vectors.7;10 (1):15. doi: 10.1186/s13071-016-1960-0.
    18. Lagatie O, Debrah LB, Debrah A, Stuyver LJ (2017) Plasma-derived parasitic microRNAs have insufficient concentrations to be used as diagnostic biomarker for detection of Onchocerca volvulus infection or treatment monitoring using LNA-based RT-qPCR. Parasitol Res. doi: 10.1007/s00436-017-5382-5.
    19. Klarmann-Schulz U, Specht S, Debrah AY, Batsa L, Ayisi-Boateng NK, Osei-Mensah J, Mubarik Y, Konadu P, Ricchiuto A, Fimmers R, Arriens S, Dubben B, Ford L, Taylor M, Hoerauf A (2017) Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial. (2017) PLoS Negl Trop Dis. 5;11(1):e0005156. doi: 10.1371/journal.pntd.0005156.
    20. Lagatie O, Ediage EN, Debrah LB, Diels L, Nolten C, Vinken P, Debrah A, Dillen L, Silber S, Stuyver LJ. (2016) Evaluation of the diagnostic potential of urinary N-Acetyltyramine-O,β-glucuronide (NATOG) as diagnostic biomarker for Onchocerca volvulus infection. Parasit Vectors. 23;9(1):302. doi: 10.1186/s13071-016-1582-6
    21. Katawa G, Layland LE, Debrah AY, von Horn C, Batsa L, Kwarteng A., Arriens, S., Taylor DW, Specht S, Achim Hoerauf A, Tomabu Adjobimey T (2015). Hyperreactive Onchocerciasis is Characterized by a Combination of Th17-Th2 Immune Responses and Reduced Regulatory T Cells. PLoS Negl Trop Dis 9(1): e3414. doi:10.1371.
    22.  Klarmann-Schulz U, Arndts K, Batsa L, Debrah A, Epp C, Fimmers R, Specht S, Layland RE, Hoerauf A. (2015). Ivermectin treatment is crucial for Plasmodium-specific Th17 mmune responses in Onchocerca volvulus-infected individuals. Parasit Vectors doi: 10.1186/s13071-015-0786-5
    23. Mand S, Debrah AY, Klarmann U, Batsa L, Marfo-Debrekyei Y, Kwarteng A, Specht S, Belda-Domene A, Fimmers R, Taylor M, Adjei O, Hoerauf A (2012). Doxycycline Improves Filarial Lymphedema Independent of Active Filarial Infection: A Randomized Controlled Trial. Clin Infect Dis. PMID: 22610930
    24. Arndts K, Deininger S, Specht S, Klarmann U, Mand S, Adjobimey T, Debrah AY, Batsa L, Kwarteng A, Epp C, Taylor M, Adjei O, Layland LE, Hoerauf A. (2012). Elevated Adaptive Immune Responses Are Associated with Latent Infections of Wuchereria bancrofti. PLoS Negl Trop Dis. 6(4): e1611. doi: 10.1371.
    25. Debrah AY, Batsa L, Albers A, Mand S, Toliat MR, Nürnberg P, Adjei O, Hoerauf A, and Pfarr K. (2011). Transforming Growth Factor-β 1 variant Leu10Pro is associated with both lack of Microfilariae and differential Microfilarial loads in the blood of people infected with lymphatic filariasis. Hum Immunol 72:1143-8
    26. Debrah, A.Y., Mand, S., Marfo-Debrekyei, Y., Batsa, L., Albers, A., Specht, S., Klarmann, U., Pfarr, K., Adjei, O., and Hoerauf, A. (2011). Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline. J Parasitol Res 17:977-85.
    27. Mand S, Debrah AY, Klarmann U, Mante S, Kwarteng A, Batsa L, Marfo-Debrekyei Y, Adjei O, Hoerauf A (2010). The role of ultrasonography in the differentiation of the various types of filaricele due to bancroftian filariasis. Acta Trop. 20 Suppl 1:S23-32
    28. Debrah AY, Mand S, Marfo-Debrekyei Y, Batsa L, Pfarr K, Lawson B, Taylor M, Adjei O, Hoerauf A (2009). Reduction in levels of plasma vascular endothelial growth factor-A and improvement in hydrocele patients by targeting endosymbiotic Wolbachia sp. in Wuchereria bancrofti with doxycycline. Am J Trop Med Hyg. 80:956-963.
    29. Hoerauf A, Specht S, Marfo-Debrekyei Y, Büttner M, Debrah AY, Mand S, Batsa L, Brattig N, Konadu P, Bandi C, Fimmers R, Adjei O, Büttner DW. (2009) Efficacy of 5-week doxycycline treatment on adult Onchocerca volvulus. Parasitol Res.104(2):437-47. doi: 10.1007/s00436-008-1217-8. Epub 2008 Oct 11.PMID:18850111
    30. Debrah AY, Mand S, Marfo-Debrekyei Y, Batsa L, Pfarr K, Buttner M, Adjei O, Buttner D, Hoerauf A (2007). Macrofilaricidal effect of 4 weeks of treatment with doxycycline on Wuchereria bancrofti. Trop Med Int Health. 12(12):1433-41.PMID:18076549
    31. Hoerauf A, Specht S, Büttner M, Pfarr K, Mand S, Fimmers R, Marfo-Debrekyei Y, Konadu P, Debrah AY, Bandi B, Brattig N, Albers A, Larbi J, Batsa L, Adjei O, Büttner DW. (2007). Wolbachia endobacteria depletion by doxycycline as antifilarial therapy is macrofilaridical in onchocerciasis. Med Microbiol Immunol 196:10.1007/s00430-00007-00062-00431
    32. Debrah AY, Mand S, Toliat MR, Marfo-Debrekyei Y, Batsa L, Nürnberg P, Lawson B, Adjei O, Hoerauf A, Pfarr K. (2007). Plasma vascular endothelial growth factor-A (VEGF-A) and VEGF-A gene polymorphism are associated with hydrocele development in lymphatic filariasis. Am J Trop Med Hyg 77: 601-608
    33. Debrah AY, Mand S, Specht S, Marfo-Debrekyei Y, Batsa L, Pfarr K, Larbi J, Lawson B, Taylor M, Adjei O, Hoerauf A. (2006). Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis. PLoS Pathog. 2(9):e92.PMID:17044733
    34. Mand S, Marfo-Debrekyei Y, Debrah A, Buettner M, Batsa L, Pfarr K, Adjei O, Hoerauf (2005). Frequent detection of worm movements in onchocercal nodules by ultrasonography. A Filaria J. 23;4(1):1 PMID:15788103
    35. Mand S, Debrah A, Batsa L, Adjei O, Hoerauf A. (2004). Reliable and frequent detection of adult Wuchereria bancrofti in Ghanaian women by ultrasonography. Trop Med Int Health. 9(10): 1111-4. PMID: 15482404
    36. Arndts K, Specht S, Debrah AY, Tamarozzi F, Klarmann Schulz U, Mand S, Batsa L, Kwarteng A, Taylor M, Adjei O, Martin C, Layland LE, Hoerauf A. (2014) Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels.PLoS Negl Trop Dis. 2014 Feb 20;8(2):e2679. doi: 10.1371

     

    ABSTRACTS PRESENTATION AT CONFERENCES

    1. Debrah AY, Specht S, Mand M, Batsa L, Klarmann U, Marfo-Debrekyei Y, Kwarteng A, Osei-Atweneboana M,Boakye D, Adjei O, Hoerauf A. (2010) Targeting Wolbachia endosymbionts in Onchocerca volvulus effectively clears persistent microfilariae in the skin of onchocerciasis patients in whom repeated ivermectin treatment had failed to clear. 59th Annual Meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, November 2010 (Oral presentation- Abstract No. 1331).

    2. Debrah AY, Batsa L., Albers A., Mand, S., Toliat, M.R., Nürnberg, P., Adjei, O., Hoerauf, A., and Pfarr, K. (2011). Transforming Growth Factor-β 1 variant Leu10Pro is associated with both lack of Microfilariae and differential Microfilarial loads in the blood of people infected with lymphatic filariasis. 1st International Society for Infectious Diseases-Neglected Tropical Diseases Meeting in Boston, Massachusetts, USA. July 2011 (Oral presentation- Abstract No. 07.011).

    3. Albers A, Batsa L, Lust L, Mensah J, Brockschmidt F, Becker T, Herold C, Klarmann U, Debrah AY, Hoerauf A, Pfarr K. Genes of the angiogenesis pathway are associated with development of hydrocele in lymphaticfilariasis - a candidate-gene analysis. 61nd Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, November 2012 (Oral presentation- Abstract No.519).

    4. Klarmann U, Debrah AY, Mand, S Linda Batsa, Sabine Specht, Kenneth Pfarr, Alexander Kwarteng, Rolf Fimmers, Mark Taylor, Ohene Adjei, Achim Hoerauf. Shortening the timeframe and dosage of anti-Wolbachia therapy: doxycycline alone versus doxycycline plus rifampicin in their efficacy against lymphatic filariasis; a randomized, double-blind, placebo-controlled trial. 61st Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, November 2012 (Oral presentation- Abstract No.522).

    5. Linda Batsa, Anna Albers, Jubin Mensah, Felix F. Brockschmidt, Tim Becker, Christine Herold, Holger Fröhlich, Lydia Lust, Sabine Mand, Ute Klarmann-Schulz, Achim Hoerauf and Kenneth M. Pfarr, Debrah A. VEGF-R3 and other angiogennic/lymphangiogenic genes are associated with development of lymphedema of filarial origin.  6th Annual meeting of Ghana Biomedical Convention, Cape Coast, Ghana, July 2013 (Oral presentation- Abstract No.36).

    6. Batsa L, Debrah AY, Albers A, Mensah J, Brockschmidt F, Becker T, Herold C, Fröhlich H, Lust L, Mand S, Klarmann-Schulz U, Hoerauf A and Pfarr KM. VEGFR3 and other angiogennic/lymphangiogenic genes are associated with development of lymphedema of filarial origin. 62nd Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Washington, USA, November 2013 (Poster presentation- Abstract No.1187).
    7. Osei-Mensah J, Debrah LB, Albers A, Lust L, Brockschmidt F, Becker T, Herold C, Mubarik Y, Fröhlich H, Pfarr K, Hoerauf A and Debrah A. Single nucleotide polymorphisms in angiogenic and inflammation pathway genes predispose infected hosts to having patent or latent lymphatic filariasis. 64th Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, October 2015 (Poster presentation- Abstract No. 1708).
    8. Osei-Mensah J, Ritter M, Debrah LB, Albers A, Mubarik Y, Layland L, Pfarr K, Hoerauf A, Debrah A  (2016). Toll-like receptor 2 expression on immune cells is elevated in cured asymptomatic individuals in lymphatic filariasis. 65th Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, October 2016 (Oral presentation- Abstract No. 598).
    9. Lagatie O, Verheyen A, Nijs N, Van Dorst B, Debrah LB, Debrah A, Stuyver, LJ   (2016). Immunoreactivity of an Onchocerca volvulus linear epitope in individuals from different Regions in Ghana. 65th Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, November 2016 (Oral presentation- Abstract No. 496).

    10. Nausch N, Antwi-Berko D, Mubarik Y, Kabiru MA, Owusu W, Owusu-Dabo E, Debrah LB, Debrah AY,Jacobsen M, Phillips RO (2017). Biomarkers and immune modulation in Buruli Ulcer disease. 66th Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, November 2017 (Oral presentation- Abstract No. 752).

    11. Klarmann-Schulz U, Debrah LB, Osei-Mensah J, Dubben B, Fischer K, Mubarik Y, Ricchiuto A, Fimmers R, Weil GJ, Kazura JW, King CL, Debrah AY, Hoerauf A (2017). The addition of albendazole to ivermectin does not reduce female worm fertility in onchocerciasis. 66th Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, November 2017 (Oral presentation- Abstract No. 533).
    12. Debrah LB, Specht S, Klarmann-Schulz U, Debrah AY, Osei-Mensah J, Dubben B, Mand S, Mubarik Y, Ricchiuto A, Fimmers R, Johnston K, Taylor M, Hoerauf A (2017). Doxycycline for the treatment of onchocerciasis: A daily dose of 100 mg for 6 weeks shows Reduction of fertile female onchocerca volvulus Worms equivalent to 200 mg/d. 66th Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, November 2017 (Oral presentation- Abstract No. 531).

    13. Mubarik Y, Debrah LB, Osei-Mensah J, 1, Fordjour FA, Debrah AY (2019). Microfilaridermia Assessment of the Efficacy of Ivermectin Alone and Ivermectin
      Plus Albendazole against Onchocerciasis. The 8th College of Health Sciences and 12th Convention of Biomedical Research Kumasi, Ghana, July 2019 (Poster presentation- Abstract No. P012). 

    14. Fordjour FA, Debrah LB, Osei-Mensah J, Mubarik Y, Gyamfi PA, Debrah AY (2019). Assessing the Involvement of Nuclear Kappa Light Chain Enhancer of Activated B cell Inhibitor-Alpha in Filarial Lymphedema Development. The 8th College of Health Sciences and 12th Convention of Biomedical Research Kumasi, Ghana, July 2019 (Oral presentation- Abstract No. 14). 

    15. Gyamfi PA, Debrah AY, Osei-Mensah J, Opoku SV,  Adu-Mensah D, Mubarik Y, Horeauf A, Debrah LB (2019). Impact of 15 Years of Mass Drug Administration on Lymphatic Filariasis Control Efforts in the Kassena Nankana East Municipal. The 8th College of Health Sciences and 12th Convention of Biomedical Research Kumasi, Ghana, July 2019 (Oral presentation- Abstract No. 4). 

    16. Kroidl I, Feichtner A, Horn S, Mwingira U, Ngenya A, Chotta G, Klarmann-Schulz U, Kuehlwein J, Hoerauf A, Osei-Mensah J, Debrah LB, Debrah AY (2019). Immune activation in patients with filarial lymphedema before and after treatment with doxycycline. 68th Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), National Harbor, MA, USA, November 2019 (Poster presentation- Abstract No. 528).

    17. Debrah LB, Osei-Mensah J, Mubarik Y, Mohammed A, Agbenyega O, Ayisi-Boateng NK, Kuehlwein JM, Klarmann-Schulz U, Hoerauf A, Debrah AY (2019). Lymphatic filariasis pathology and acute Dermatolymphangioadenitis (ADLA) attacks using a mobile phone-based tool by community health volunteers in Ghana. 68th Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), National Harbor, MA, USA, November 2019 (Oral presentation- Abstract No. 1283).

    18. Weier C, Albers A, Debrah LB, Mante S, Mand S, Stoffel-Wagner B, Klarmann-Schulz U, Debrah A, Pfarr K, Hoerauf A. Mediators of vascular permeability and lymph/angiogenesis are markers for hydroceles caused by Wuchereria bancrofti infection. 64th Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, October 2015 (Oral presentation- Abstract No. 1709).

    19. Klarmann-Schulz U, Batsa L, Specht S, Debrah AY, Osei-Mensah J, Ayisi-Boateng NK, Mubarik Y, Ford L, Konadu P, Mark J. Taylor MJ, Achim Hoerauf. Comparison of doxycycline, minocycline, doxycycline plus albendazole and albendazole alone in their efficacy against onchocerciasis. 64th Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, October 2015 (Oral presentation- Abstract No. 639).

    20. Debrah AY, Sabine Specht, Linda Batsa, Ute Klarmann, Sabine Mand, Alexander Kwarteng, Mike Osei-Atweneboana,Daniel Boakye, Ohene Adjei and Achim Hoerauf. Doxycycline treatment shows a strong embryostatic effect and clearance of persistent microfilariae in the skin of onchocerciasis patients in whom repeated ivermectin treatment had failed to clear microfilaridermia. 63rd Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), New Orleans, USA, November 2014 (Oral presentation- Abstract No. 1207).

    21. Debrah AY, Sabine Mand, Henry Atawurah, Nana K. Ayisi-Boateng, Linda Batsa, Alexander Kwarteng, Jubin Osei-Mensah, Yusif Mubarik, Sabine Specht, Arcangelo Ricchiuto, Rolf Fimmers, Achim Hoerauf, Ute Klarmann-Schulz. Long-term improvement of hydrocele size after ultrasound-guided aspiration. 63rd Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), New Orleans, USA, November 2014 (Oral presentation- Abstract No. 1210).

    22. Michelle C. Stanton, Square Z. Mkwanda, Debrah AY, Linda B. Debrah, Achim Hoerauf, Nana-KwadwoBiritwum, Abigail Best, Matthew Cliffe, Louise A. Kelly-Hope. Utilizing the community health worker network for lymphatic filariasis (LF) morbidity monitoring: the development of an SMS-based surveillance tool. 63rd Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), New Orleans, USA, November 2014 (Poster presentation- Abstract No. 1689).

    23. Torres M, Pilotte N, Adjobimey T, Specht S, Terry F, Debrah A, Batsa L, Kwarteng A, de Groot A, Williams S, Hoerauf A. Evaluation of HLA Immunoinformatics for the identification of Brugia malayi putative T cellepitopes conserved with Wuchereria bancrofti andLloa loa. 63rd Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), New Orleans, USA, November 2014 (Poster presentation- Abstract No. 1713).

    24. Hoerauf A, Klarmann U, Debrah AY, Batsa L, Adjei O, Mand S. The sensitivity of standard circulating filarial antigen tests and ultrasonography for individual diagnostics and epidemiological surveillance of bancroftian filariasis. 59th Annual meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, USA, November 2010 (Oral presentation- Abstract No.1328)

    25. Debrah AY, Mand S, Toliat MR, Marfo-Debrekyei Y, Batsa L, Nuernberg P, Bernard Lawson, Adjei O, HoeraufA, Pfarr K. Targeting endosymbiotic Wolbachia in Wuchereria bancrofti reduces plasma VEGF with amelioration of condition of hydrocele patients. International Congress on Parasitology XII (ICOPA XII) in Melbourne, Australia, August 2010 (Oral Presentation and co-Chairman of one of the symposia- Abstract no. 323). 

    26. Debrah AY, Specht S, Mand M, Batsa L, Klarmann U, Marfo-Debrekyei Y, Kwarteng A, Osei-Atweneboana M,Boakye D, Adjei O, Hoerauf A. Targeting Wolbachia endosymbionts in Onchocerca volvulus effectively clears persistent microfilariae in the skin of onchocerciasis patients in whom repeated ivermectin treatment had failed to clear. Biannual Meeting of Royal Society of Tropical Medicine and Hygiene (RSTMH), Liverpool, UK, October 2010 (Poster presentation- Abstract No. P.04).

    27. Batsa L, Specht S, Debrah AY, Mand M, Klarmann U, Marfo-Debrekyei Y, Kwarteng A, Osei-Atweneboana M,Boakye D, Adjei O, Hoerauf A. Targeting Wolbachia endosymbionts in Onchocerca volvulus effectively clears persistent microfilariae in the skin of onchocerciasis patients in whom repeated ivermectin treatment had failed to clear. 6th International Wolbachia Conference. San Francisco, USA. June 2010 (Oral presentation- Abstract No. 7-11).

    28. Mand S, Debrah AY, Specht S, Kwarteng A, Klarmann U, Fimmers R, Batsa L, Marfo-Debrekyei Y, Adjei O, Hoerauf A. Doxycycline improves filarial lymphoedema independent of its action on Wolbachia. 58th Annual Meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Washington, USA, November 2009 (Oral presentation- Abstract No. 1102).

    29. Adjei O, Debrah AY, Mand M, Specht S, Batsa L, Marfo-Debrekyei Y, Pfarr K, Hoerauf A. Macrofilaricidal activity of doxycycline in human onchocerciasis in Ghana. 2nd  Annual Scientific Conference of College of Health Sciences of Kwame Nkrumah University of Science Technology, Kumasi, Ghana. November 2009 (Oral presentation- Abstract No. F39).

    30. Debrah AY, Mand S, Toliat MR, Marfo-Debrekyei Y, Batsa L, Nuernberg P, Bernard Lawson, Adjei O, HoeraufA, Pfarr K. Targeting endosymbiotic Wolbachia in Wuchereria bancrofti reduces plasma VEGF-A and improves condition of hydrocele patients. 5th International Wolbachia Meeting in Crete, Greece, June, 2008 (Oral Presentation Abstract no. F2). 

    31. Debrah AY, Mand S, Marfo-Debrekyei Y, Batsa L, Adjei O, Pfarr K, Hoerauf A. Onchocerciasis control: Vision for the Future- Antibiotic therapy: Progress from the field - onchocerciasis. A workshop organized by the Royal Society of Tropical Medicine and Hygiene at Elmina, Ghana April 2008. (Oral presentation).

    32. Debrah AY, Mand S, Toliat MR, Marfo-Debrekyei Y, Batsa L, Nuernberg P, Bernard Lawson, Adjei O, HoeraufA, Pfarr K. Targeting endosymbiotic Wolbachia in Wuchereria bancrofti reduces plasma VEGF-A and improves condition of hydrocele patients. 56th Annual Meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Philadelphia, USA, November 2007 (Oral presentation and won Travel award for this meeting- Abstract No. 388).

    33. Hoerauf A, Specht S, Buttner M, Pfarr K, Mand S, Filmmers R, Konadu P, Debrah AY, Bandi C, Brattig NW, Albers A, Batsa L, Adjei O, Buettner D. Wolbachia endobacteria depletion by doxycycline as antifilarial therapy is macrofilaricidal  in onchocerciasis. 56th Annual Meeting of American Society of Tropical Medicine and Hygiene (ASTMH), Philadelphia, USA, November 2007 (Oral presentation - Abstract No. 389).

    34. Debrah AY, Mand S, Marfo-Debrekyei Y, Batsa L, Pfarr K, Adjei O, Hoerauf A. Effect of targeting endosymbiotic Wolbachia in Wuchereria bancrofti on pathology of filariasis infection. 4th International Wolbachia Meeting in Puerto Rico, Caribbean, June 2006 (Oral Presentation Abstract no A-1).

    35. Debrah AY, Sabine Mand S, Marfo-Debrekyei Y, Batsa L, Pfarr K, Adjei O, Hoerauf A. Evaluation of endosymbiotic Wolbachia DNA in blood as a potential tool for diagnosis of lymphatic filariasis infection. 4thInternational Wolbachia Meeting in Puerto Rico, Caribbean, June 2006 (Oral Presentation Abstract no A-2).

    36. Debrah AY, Sabine Mand S, Marfo-Debrekyei Y, Batsa L, Pfarr K, Adjei O, Hoerauf A. Effect of targeting Endosymbiotic Wolbachia in Wuchereria bancroftian on macrofilaricidal effect, over-expression of VEGF-C/VEGFR-3 and lymphatic dilation in lymphatic filariasis-Results from a 6 weeks trial with doxycycline 22ndGerman Parasitologists Conference in Vienna, Austria. April 2006 (Oral Presentation Abstract no. 23).

     

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