Using the intrinsic case study approach, this study sought to find out the experiences of a female student with rare mobility challenges and how her specific needs were being met in a university in Ghana. The Convention on the Rights of Persons with Disabilities stipulates that lack of the provision of reasonable accommodation is discriminatory. However, not much is known on this issue in the higher education setting in Africa regarding accessibility in the built environment. The study aimed to help fill this gap. It involved the use of semi-structured interviews in 2015 and 2016. Content analysis was used for the data. The study concluded that where there were unique accessibility challenges, it was inappropriate to leave the specific needs of a student with disability to the discretion of individuals. It recommends attitudinal change and institutionalising reasonable accommodation in the university.