Adsorption of some Salicylates onto the Sclerotium of Pleurotus: Implications in Food-Drug Interactions

Abstract

The absorptive properties of powdered sclerotium of Pleurotus tuber-regium were investigated using acetyl-salicylic acid and sodium salicylate. Activated charcoal was used as the basis for comparison. The effects of various experimental conditions such as pH, temperature, ionic strength and organic matter (using citrated guinea pig blood) on adsorption were investigated. The results show that the extent of adsorption was dependent on drug type, pH, temperature and ionic strength. The high adsorptive capacity of the powdered sclerotium could have serious implications when co-administered with salicylates.