Some Toxic-Effects of Griffonin in Mice

Abstract

Acute and subacute toxicity tests show that griffonin has slight central nervous system depressant action, resulting in reduced locomotor activity in mice. The, mice had increased urination and passed semi-solid stools, suggesting muscarinic activity. The LD₅₀ of griffonin in mice was 4.31±0.58g/kg body weight. In the subacute toxicity tests, mice were exposed to griffonin for six weeks. Griffonin caused an initial reduction in red blood cell count which later returned to normal. Microscopic examination of sections of the lung, heart, kidney, spleen and liver showed that griffonin had no effect on the lung and spleen but had dose- and time-dependent effects on the heart, liver and kidney.