Comparative Sustained Release Matrix Capacities of some Polymer Matrices in Theophylline Hydrate Tablets

S.I Ofoefule; C. Amanambu

doi:10.4314/just.v18i2.871

S.I Ofoefule
C. Amanambu

DOI: https://doi.org/10.4314/just.v18i2.871

Keywords: Sustained Release, Matrix Capacity, Theophylline Hydrate

Abstract

Sustained release matrix capacities of three polymeric materials in theophylline hydrate tablets were studied. The polymers (Carbopol 941, Eudragit L-100-55 and Ethylcellulose) were used at 0.20 and 30% w/w concentration levels. Dicalcium phosphate dihydrate and stearic acid were used as filler and lubricant respectively. Theophylline hydrate tablets were formulated using the perfect compression method. In vitro drug release studies on the tablets were monitored over 8hrs in 0.1 N HCI, simulated gastric fluid without pepsin (SGF) and simulated intestinal fluid without pancreation (SIF).

There was prolonged release of theophylline from 20 and 30% w/w of either Carbopol 941 (CP 941) or Eudragit L-100-55 Ethylcellulose (EC). Release rate of theophylline from CP 941 and EC was slowest in SIF, while the release rate from EDL was fastest with this media. The comparative matrix capacities of these polymers were in the order of CP 941>EDL>EC.